| Full name: protein arginine methyltransferase 5 | Alias Symbol: SKB1Hs | ||
| Type: protein-coding gene | Cytoband: 14q11.2 | ||
| Entrez ID: 10419 | HGNC ID: HGNC:10894 | Ensembl Gene: ENSG00000100462 | OMIM ID: 604045 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PRMT5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRMT5 | 10419 | 217786_at | 0.2238 | 0.6535 | |
| GSE20347 | PRMT5 | 10419 | 217786_at | 0.3329 | 0.1933 | |
| GSE23400 | PRMT5 | 10419 | 217786_at | 0.2558 | 0.0032 | |
| GSE26886 | PRMT5 | 10419 | 1564520_s_at | 0.8022 | 0.0050 | |
| GSE29001 | PRMT5 | 10419 | 217786_at | 0.0920 | 0.8279 | |
| GSE38129 | PRMT5 | 10419 | 217786_at | 0.4440 | 0.0103 | |
| GSE45670 | PRMT5 | 10419 | 217786_at | 0.0614 | 0.7978 | |
| GSE53622 | PRMT5 | 10419 | 134171 | 0.0118 | 0.9181 | |
| GSE53624 | PRMT5 | 10419 | 134171 | -0.0854 | 0.3921 | |
| GSE63941 | PRMT5 | 10419 | 217786_at | 1.8614 | 0.0006 | |
| GSE77861 | PRMT5 | 10419 | 217786_at | 0.2681 | 0.5815 | |
| GSE97050 | PRMT5 | 10419 | A_23_P76851 | 0.1269 | 0.6490 | |
| SRP007169 | PRMT5 | 10419 | RNAseq | -1.0128 | 0.0555 | |
| SRP008496 | PRMT5 | 10419 | RNAseq | -1.0443 | 0.0064 | |
| SRP064894 | PRMT5 | 10419 | RNAseq | -0.1556 | 0.4136 | |
| SRP133303 | PRMT5 | 10419 | RNAseq | 0.3374 | 0.0920 | |
| SRP159526 | PRMT5 | 10419 | RNAseq | 0.2671 | 0.2985 | |
| SRP193095 | PRMT5 | 10419 | RNAseq | 0.0545 | 0.7532 | |
| SRP219564 | PRMT5 | 10419 | RNAseq | 0.1270 | 0.6948 | |
| TCGA | PRMT5 | 10419 | RNAseq | 0.2081 | 0.0002 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by PRMT5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRMT5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRMT5 | 10419 | 9 | 2 | 19 | |
| GSE20123 | PRMT5 | 10419 | 9 | 2 | 19 | |
| GSE43470 | PRMT5 | 10419 | 7 | 2 | 34 | |
| GSE46452 | PRMT5 | 10419 | 17 | 2 | 40 | |
| GSE47630 | PRMT5 | 10419 | 11 | 10 | 19 | |
| GSE54993 | PRMT5 | 10419 | 3 | 11 | 56 | |
| GSE54994 | PRMT5 | 10419 | 18 | 5 | 30 | |
| GSE60625 | PRMT5 | 10419 | 0 | 2 | 9 | |
| GSE74703 | PRMT5 | 10419 | 6 | 2 | 28 | |
| GSE74704 | PRMT5 | 10419 | 4 | 1 | 15 | |
| TCGA | PRMT5 | 10419 | 26 | 16 | 54 |
Total number of gains: 110; Total number of losses: 55; Total Number of normals: 323.
Somatic mutations of PRMT5:
Generating mutation plots.
Highly correlated genes for PRMT5:
Showing top 20/168 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRMT5 | CCDC142 | 0.738244 | 3 | 0 | 3 |
| PRMT5 | TTC7A | 0.716801 | 3 | 0 | 3 |
| PRMT5 | NUP62CL | 0.708958 | 3 | 0 | 3 |
| PRMT5 | TMEM102 | 0.700704 | 3 | 0 | 3 |
| PRMT5 | GLTPD2 | 0.697078 | 3 | 0 | 3 |
| PRMT5 | PSMB5 | 0.681035 | 12 | 0 | 10 |
| PRMT5 | IL17RE | 0.670134 | 4 | 0 | 3 |
| PRMT5 | TYMP | 0.663658 | 3 | 0 | 3 |
| PRMT5 | NPW | 0.661066 | 5 | 0 | 3 |
| PRMT5 | L3HYPDH | 0.660434 | 3 | 0 | 3 |
| PRMT5 | MTFP1 | 0.651846 | 5 | 0 | 4 |
| PRMT5 | EME1 | 0.644915 | 3 | 0 | 3 |
| PRMT5 | CCDC43 | 0.644584 | 4 | 0 | 3 |
| PRMT5 | ELMO3 | 0.642366 | 5 | 0 | 3 |
| PRMT5 | BRD7 | 0.628749 | 4 | 0 | 4 |
| PRMT5 | ETAA1 | 0.625812 | 5 | 0 | 4 |
| PRMT5 | RTCB | 0.62538 | 5 | 0 | 5 |
| PRMT5 | FAM83B | 0.620307 | 4 | 0 | 3 |
| PRMT5 | CORO2A | 0.619004 | 4 | 0 | 3 |
| PRMT5 | DNLZ | 0.618779 | 3 | 0 | 3 |
For details and further investigation, click here
