XRCC6

 

Full name: X-ray repair cross complementing 6 Alias Symbol: D22S731|D22S671|KU70|ML8
Type: protein-coding gene Cytoband: 22q13.2
Entrez ID: 2547 HGNC ID: HGNC:4055 Ensembl Gene: ENSG00000196419 OMIM ID: 152690
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of XRCC6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 XRCC6 2547 200792_at 0.2294 0.3688
GSE20347 XRCC6 2547 200792_at -0.0437 0.7898
GSE23400 XRCC6 2547 200792_at 0.2463 0.0001
GSE26886 XRCC6 2547 200792_at 0.1382 0.2899
GSE29001 XRCC6 2547 200792_at -0.1411 0.7627
GSE38129 XRCC6 2547 200792_at 0.1473 0.1725
GSE45670 XRCC6 2547 200792_at 0.1549 0.2587
GSE53622 XRCC6 2547 78990 0.2909 0.0000
GSE53624 XRCC6 2547 78990 0.5082 0.0000
GSE63941 XRCC6 2547 200792_at 0.5964 0.0796
GSE77861 XRCC6 2547 200792_at 0.3223 0.1387
GSE97050 XRCC6 2547 A_23_P120942 0.1337 0.5037
SRP007169 XRCC6 2547 RNAseq 0.2422 0.5463
SRP008496 XRCC6 2547 RNAseq 0.1158 0.6278
SRP064894 XRCC6 2547 RNAseq 0.4621 0.0070
SRP133303 XRCC6 2547 RNAseq 0.1198 0.4588
SRP159526 XRCC6 2547 RNAseq 0.4687 0.0095
SRP193095 XRCC6 2547 RNAseq 0.0563 0.6771
SRP219564 XRCC6 2547 RNAseq 0.2493 0.5117
TCGA XRCC6 2547 RNAseq 0.1396 0.0005

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by XRCC6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of XRCC6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 XRCC6 2547 6 5 19
GSE20123 XRCC6 2547 6 4 20
GSE43470 XRCC6 2547 5 6 32
GSE46452 XRCC6 2547 31 2 26
GSE47630 XRCC6 2547 9 4 27
GSE54993 XRCC6 2547 3 6 61
GSE54994 XRCC6 2547 11 8 34
GSE60625 XRCC6 2547 5 0 6
GSE74703 XRCC6 2547 5 4 27
GSE74704 XRCC6 2547 3 2 15
TCGA XRCC6 2547 26 14 56

Total number of gains: 110; Total number of losses: 55; Total Number of normals: 323.  

 

Somatic mutations of XRCC6:

 

Generating mutation plots.

 

Highly correlated genes for XRCC6:

 

Showing top 20/1104 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
XRCC6POLB0.841461303
XRCC6AP1AR0.826601303
XRCC6CIB10.82443303
XRCC6WIPF20.762565303
XRCC6CSNK2A20.75953403
XRCC6DHX570.742861404
XRCC6TPD52L20.737955303
XRCC6EBNA1BP20.737674303
XRCC6CNOT100.736741303
XRCC6SCNM10.734959303
XRCC6ZNF6910.733002303
XRCC6CNOT70.729075404
XRCC6TRIM320.723984303
XRCC6ZNF7400.723233303
XRCC6LAMTOR10.722153303
XRCC6DAPK30.719437303
XRCC6MASTL0.713053403
XRCC6POLR2E0.711016404
XRCC6AZIN10.709445303
XRCC6BTF3L40.709128303

For details and further investigation, click here