| Full name: glutamate dehydrogenase 1 | Alias Symbol: GDH | ||
| Type: protein-coding gene | Cytoband: 10q23.2 | ||
| Entrez ID: 2746 | HGNC ID: HGNC:4335 | Ensembl Gene: ENSG00000148672 | OMIM ID: 138130 |
| Drug and gene relationship at DGIdb | |||
Expression of GLUD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GLUD1 | 2746 | 200947_s_at | -0.0573 | 0.9408 | |
| GSE20347 | GLUD1 | 2746 | 200947_s_at | -0.5011 | 0.0017 | |
| GSE23400 | GLUD1 | 2746 | 200947_s_at | -0.0538 | 0.4212 | |
| GSE26886 | GLUD1 | 2746 | 200947_s_at | -1.2471 | 0.0000 | |
| GSE29001 | GLUD1 | 2746 | 200947_s_at | -0.4598 | 0.0571 | |
| GSE38129 | GLUD1 | 2746 | 200947_s_at | -0.2810 | 0.2820 | |
| GSE45670 | GLUD1 | 2746 | 200947_s_at | -0.1496 | 0.2844 | |
| GSE53622 | GLUD1 | 2746 | 45920 | -0.3420 | 0.0000 | |
| GSE53624 | GLUD1 | 2746 | 45920 | -0.2297 | 0.0045 | |
| GSE63941 | GLUD1 | 2746 | 200947_s_at | -0.6611 | 0.1645 | |
| GSE77861 | GLUD1 | 2746 | 200947_s_at | 0.0554 | 0.8088 | |
| GSE97050 | GLUD1 | 2746 | A_23_P138665 | -0.1999 | 0.4774 | |
| SRP007169 | GLUD1 | 2746 | RNAseq | -0.3453 | 0.5392 | |
| SRP008496 | GLUD1 | 2746 | RNAseq | -0.4597 | 0.1816 | |
| SRP064894 | GLUD1 | 2746 | RNAseq | -0.6036 | 0.0000 | |
| SRP133303 | GLUD1 | 2746 | RNAseq | 0.0185 | 0.9315 | |
| SRP159526 | GLUD1 | 2746 | RNAseq | -0.3490 | 0.3381 | |
| SRP193095 | GLUD1 | 2746 | RNAseq | -0.5213 | 0.0001 | |
| SRP219564 | GLUD1 | 2746 | RNAseq | -0.4138 | 0.0520 | |
| TCGA | GLUD1 | 2746 | RNAseq | -0.0342 | 0.4358 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by GLUD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GLUD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GLUD1 | 2746 | 1 | 7 | 22 | |
| GSE20123 | GLUD1 | 2746 | 1 | 6 | 23 | |
| GSE43470 | GLUD1 | 2746 | 0 | 8 | 35 | |
| GSE46452 | GLUD1 | 2746 | 0 | 11 | 48 | |
| GSE47630 | GLUD1 | 2746 | 2 | 14 | 24 | |
| GSE54993 | GLUD1 | 2746 | 7 | 0 | 63 | |
| GSE54994 | GLUD1 | 2746 | 1 | 12 | 40 | |
| GSE60625 | GLUD1 | 2746 | 0 | 0 | 11 | |
| GSE74703 | GLUD1 | 2746 | 0 | 6 | 30 | |
| GSE74704 | GLUD1 | 2746 | 0 | 4 | 16 | |
| TCGA | GLUD1 | 2746 | 7 | 27 | 62 |
Total number of gains: 19; Total number of losses: 95; Total Number of normals: 374.
Somatic mutations of GLUD1:
Generating mutation plots.
Highly correlated genes for GLUD1:
Showing top 20/583 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GLUD1 | RHBDD1 | 0.832829 | 3 | 0 | 3 |
| GLUD1 | TMBIM6 | 0.760804 | 3 | 0 | 3 |
| GLUD1 | CDK9 | 0.759088 | 3 | 0 | 3 |
| GLUD1 | ZNF436 | 0.757964 | 3 | 0 | 3 |
| GLUD1 | RAB35 | 0.75421 | 3 | 0 | 3 |
| GLUD1 | LMBRD2 | 0.750322 | 3 | 0 | 3 |
| GLUD1 | MRPL27 | 0.749137 | 3 | 0 | 3 |
| GLUD1 | PIK3CB | 0.746465 | 3 | 0 | 3 |
| GLUD1 | MRFAP1L1 | 0.745436 | 3 | 0 | 3 |
| GLUD1 | POLDIP3 | 0.744129 | 3 | 0 | 3 |
| GLUD1 | SRP68 | 0.7406 | 3 | 0 | 3 |
| GLUD1 | GLYR1 | 0.738248 | 4 | 0 | 4 |
| GLUD1 | PNN | 0.737224 | 4 | 0 | 3 |
| GLUD1 | NCKAP1 | 0.733446 | 3 | 0 | 3 |
| GLUD1 | SAMM50 | 0.729158 | 3 | 0 | 3 |
| GLUD1 | MRPL11 | 0.72659 | 3 | 0 | 3 |
| GLUD1 | ZNF564 | 0.726443 | 3 | 0 | 3 |
| GLUD1 | C6orf89 | 0.723111 | 3 | 0 | 3 |
| GLUD1 | HEATR5A | 0.712672 | 3 | 0 | 3 |
| GLUD1 | UBXN1 | 0.711368 | 3 | 0 | 3 |
For details and further investigation, click here
