| Full name: syntaxin 18 | Alias Symbol: Ufe1 | ||
| Type: protein-coding gene | Cytoband: 4p16.3-p16.2 | ||
| Entrez ID: 53407 | HGNC ID: HGNC:15942 | Ensembl Gene: ENSG00000168818 | OMIM ID: 606046 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of STX18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STX18 | 53407 | 218763_at | -0.0605 | 0.8622 | |
| GSE20347 | STX18 | 53407 | 218763_at | -0.1935 | 0.0374 | |
| GSE23400 | STX18 | 53407 | 218763_at | -0.0918 | 0.0101 | |
| GSE26886 | STX18 | 53407 | 218763_at | -0.4709 | 0.0182 | |
| GSE29001 | STX18 | 53407 | 218763_at | -0.1098 | 0.6581 | |
| GSE38129 | STX18 | 53407 | 218763_at | -0.0775 | 0.3596 | |
| GSE45670 | STX18 | 53407 | 218763_at | -0.0584 | 0.6124 | |
| GSE53622 | STX18 | 53407 | 6702 | 0.1025 | 0.0468 | |
| GSE53624 | STX18 | 53407 | 6702 | -0.0872 | 0.1041 | |
| GSE63941 | STX18 | 53407 | 218763_at | -0.4473 | 0.1645 | |
| GSE77861 | STX18 | 53407 | 218763_at | -0.1621 | 0.1504 | |
| GSE97050 | STX18 | 53407 | A_23_P135616 | 0.1002 | 0.6339 | |
| SRP007169 | STX18 | 53407 | RNAseq | -0.1149 | 0.7653 | |
| SRP008496 | STX18 | 53407 | RNAseq | -0.1490 | 0.5563 | |
| SRP064894 | STX18 | 53407 | RNAseq | 0.0556 | 0.6979 | |
| SRP133303 | STX18 | 53407 | RNAseq | 0.0484 | 0.7278 | |
| SRP159526 | STX18 | 53407 | RNAseq | -0.1875 | 0.3583 | |
| SRP193095 | STX18 | 53407 | RNAseq | -0.5043 | 0.0009 | |
| SRP219564 | STX18 | 53407 | RNAseq | 0.0504 | 0.8548 | |
| TCGA | STX18 | 53407 | RNAseq | -0.1487 | 0.0104 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by STX18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STX18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STX18 | 53407 | 0 | 17 | 13 | |
| GSE20123 | STX18 | 53407 | 0 | 17 | 13 | |
| GSE43470 | STX18 | 53407 | 0 | 17 | 26 | |
| GSE46452 | STX18 | 53407 | 1 | 36 | 22 | |
| GSE47630 | STX18 | 53407 | 1 | 19 | 20 | |
| GSE54993 | STX18 | 53407 | 10 | 0 | 60 | |
| GSE54994 | STX18 | 53407 | 3 | 12 | 38 | |
| GSE60625 | STX18 | 53407 | 0 | 0 | 11 | |
| GSE74703 | STX18 | 53407 | 0 | 13 | 23 | |
| GSE74704 | STX18 | 53407 | 0 | 9 | 11 | |
| TCGA | STX18 | 53407 | 7 | 47 | 42 |
Total number of gains: 22; Total number of losses: 187; Total Number of normals: 279.
Somatic mutations of STX18:
Generating mutation plots.
Highly correlated genes for STX18:
Showing top 20/485 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STX18 | PEX2 | 0.805153 | 3 | 0 | 3 |
| STX18 | HDAC3 | 0.788315 | 3 | 0 | 3 |
| STX18 | OXNAD1 | 0.780281 | 3 | 0 | 3 |
| STX18 | DLD | 0.770751 | 3 | 0 | 3 |
| STX18 | TMEM51 | 0.746004 | 4 | 0 | 4 |
| STX18 | PPP2CA | 0.736083 | 3 | 0 | 3 |
| STX18 | GALM | 0.732657 | 3 | 0 | 3 |
| STX18 | ASCC3 | 0.732126 | 3 | 0 | 3 |
| STX18 | CFHR3 | 0.722355 | 3 | 0 | 3 |
| STX18 | VAMP7 | 0.708197 | 4 | 0 | 4 |
| STX18 | IMPACT | 0.707041 | 3 | 0 | 3 |
| STX18 | VPS16 | 0.705796 | 3 | 0 | 3 |
| STX18 | RPUSD4 | 0.702217 | 4 | 0 | 3 |
| STX18 | TRIM5 | 0.701953 | 3 | 0 | 3 |
| STX18 | HSPA9 | 0.701783 | 3 | 0 | 3 |
| STX18 | GNPDA2 | 0.701566 | 3 | 0 | 3 |
| STX18 | TBC1D8 | 0.700103 | 3 | 0 | 3 |
| STX18 | RAB2A | 0.697557 | 4 | 0 | 4 |
| STX18 | GLRX2 | 0.695228 | 3 | 0 | 3 |
| STX18 | ABCD4 | 0.694328 | 3 | 0 | 3 |
For details and further investigation, click here
