| Full name: YTH N6-methyladenosine RNA binding protein 2 | Alias Symbol: HGRG8|NY-REN-2|CAHL | ||
| Type: protein-coding gene | Cytoband: 1p35.3 | ||
| Entrez ID: 51441 | HGNC ID: HGNC:31675 | Ensembl Gene: ENSG00000198492 | OMIM ID: 610640 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of YTHDF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | YTHDF2 | 51441 | 217812_at | 0.1162 | 0.6645 | |
| GSE20347 | YTHDF2 | 51441 | 217812_at | 0.0195 | 0.8643 | |
| GSE23400 | YTHDF2 | 51441 | 217812_at | 0.2507 | 0.0018 | |
| GSE26886 | YTHDF2 | 51441 | 222430_s_at | -1.0483 | 0.0003 | |
| GSE29001 | YTHDF2 | 51441 | 217812_at | -0.1134 | 0.6173 | |
| GSE38129 | YTHDF2 | 51441 | 217812_at | 0.1659 | 0.1120 | |
| GSE45670 | YTHDF2 | 51441 | 217812_at | 0.2149 | 0.0594 | |
| GSE53622 | YTHDF2 | 51441 | 27919 | -0.0034 | 0.9629 | |
| GSE53624 | YTHDF2 | 51441 | 16692 | -0.0476 | 0.2155 | |
| GSE63941 | YTHDF2 | 51441 | 222430_s_at | 0.0758 | 0.7784 | |
| GSE77861 | YTHDF2 | 51441 | 217812_at | -0.1957 | 0.3424 | |
| GSE97050 | YTHDF2 | 51441 | A_23_P103414 | 0.1522 | 0.5076 | |
| SRP007169 | YTHDF2 | 51441 | RNAseq | 0.5636 | 0.1079 | |
| SRP008496 | YTHDF2 | 51441 | RNAseq | 0.7775 | 0.0012 | |
| SRP064894 | YTHDF2 | 51441 | RNAseq | -0.0635 | 0.5804 | |
| SRP133303 | YTHDF2 | 51441 | RNAseq | 0.2163 | 0.1048 | |
| SRP159526 | YTHDF2 | 51441 | RNAseq | -0.0103 | 0.9673 | |
| SRP193095 | YTHDF2 | 51441 | RNAseq | -0.1412 | 0.0964 | |
| SRP219564 | YTHDF2 | 51441 | RNAseq | -0.1479 | 0.5815 | |
| TCGA | YTHDF2 | 51441 | RNAseq | 0.0601 | 0.1820 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by YTHDF2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of YTHDF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | YTHDF2 | 51441 | 0 | 6 | 24 | |
| GSE20123 | YTHDF2 | 51441 | 0 | 5 | 25 | |
| GSE43470 | YTHDF2 | 51441 | 3 | 6 | 34 | |
| GSE46452 | YTHDF2 | 51441 | 5 | 1 | 53 | |
| GSE47630 | YTHDF2 | 51441 | 8 | 3 | 29 | |
| GSE54993 | YTHDF2 | 51441 | 2 | 1 | 67 | |
| GSE54994 | YTHDF2 | 51441 | 10 | 4 | 39 | |
| GSE60625 | YTHDF2 | 51441 | 0 | 0 | 11 | |
| GSE74703 | YTHDF2 | 51441 | 2 | 4 | 30 | |
| GSE74704 | YTHDF2 | 51441 | 0 | 0 | 20 | |
| TCGA | YTHDF2 | 51441 | 11 | 21 | 64 |
Total number of gains: 41; Total number of losses: 51; Total Number of normals: 396.
Somatic mutations of YTHDF2:
Generating mutation plots.
Highly correlated genes for YTHDF2:
Showing top 20/549 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| YTHDF2 | NFXL1 | 0.821182 | 3 | 0 | 3 |
| YTHDF2 | SH3PXD2A | 0.812427 | 3 | 0 | 3 |
| YTHDF2 | ARFGAP2 | 0.81096 | 3 | 0 | 3 |
| YTHDF2 | SCOC | 0.794644 | 3 | 0 | 3 |
| YTHDF2 | FAM174A | 0.782738 | 3 | 0 | 3 |
| YTHDF2 | GTF2A1 | 0.782059 | 3 | 0 | 3 |
| YTHDF2 | FBXL5 | 0.770461 | 3 | 0 | 3 |
| YTHDF2 | OXNAD1 | 0.762391 | 3 | 0 | 3 |
| YTHDF2 | SYPL1 | 0.761565 | 3 | 0 | 3 |
| YTHDF2 | STK38 | 0.760773 | 4 | 0 | 4 |
| YTHDF2 | RBM5 | 0.75688 | 3 | 0 | 3 |
| YTHDF2 | ABHD16A | 0.754273 | 3 | 0 | 3 |
| YTHDF2 | BCL2L1 | 0.748577 | 3 | 0 | 3 |
| YTHDF2 | CNOT6L | 0.747729 | 3 | 0 | 3 |
| YTHDF2 | ZNF419 | 0.74527 | 3 | 0 | 3 |
| YTHDF2 | OMA1 | 0.740008 | 3 | 0 | 3 |
| YTHDF2 | TP53RK | 0.738742 | 4 | 0 | 4 |
| YTHDF2 | ZNF416 | 0.736604 | 4 | 0 | 4 |
| YTHDF2 | DPM1 | 0.734584 | 3 | 0 | 3 |
| YTHDF2 | CUL3 | 0.731975 | 4 | 0 | 4 |
For details and further investigation, click here
