| Full name: UPF2 regulator of nonsense mediated mRNA decay | Alias Symbol: RENT2|DKFZP434D222|KIAA1408|smg-3 | ||
| Type: protein-coding gene | Cytoband: 10p14 | ||
| Entrez ID: 26019 | HGNC ID: HGNC:17854 | Ensembl Gene: ENSG00000151461 | OMIM ID: 605529 |
| Drug and gene relationship at DGIdb | |||
Expression of UPF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UPF2 | 26019 | 203519_s_at | -0.0347 | 0.9320 | |
| GSE20347 | UPF2 | 26019 | 203519_s_at | 0.2737 | 0.0378 | |
| GSE23400 | UPF2 | 26019 | 203519_s_at | 0.2464 | 0.0009 | |
| GSE26886 | UPF2 | 26019 | 203519_s_at | -0.5405 | 0.0112 | |
| GSE29001 | UPF2 | 26019 | 203519_s_at | 0.4488 | 0.0399 | |
| GSE38129 | UPF2 | 26019 | 203519_s_at | 0.0955 | 0.4296 | |
| GSE45670 | UPF2 | 26019 | 203519_s_at | 0.0522 | 0.7616 | |
| GSE53622 | UPF2 | 26019 | 49941 | 0.1132 | 0.0487 | |
| GSE53624 | UPF2 | 26019 | 49941 | 0.3733 | 0.0000 | |
| GSE63941 | UPF2 | 26019 | 203519_s_at | -0.5044 | 0.2626 | |
| GSE77861 | UPF2 | 26019 | 203519_s_at | -0.0663 | 0.8318 | |
| GSE97050 | UPF2 | 26019 | A_33_P3218760 | 0.1652 | 0.4863 | |
| SRP007169 | UPF2 | 26019 | RNAseq | 0.9435 | 0.0141 | |
| SRP008496 | UPF2 | 26019 | RNAseq | 0.8203 | 0.0045 | |
| SRP064894 | UPF2 | 26019 | RNAseq | 0.1352 | 0.2315 | |
| SRP133303 | UPF2 | 26019 | RNAseq | -0.0374 | 0.7470 | |
| SRP159526 | UPF2 | 26019 | RNAseq | -0.4511 | 0.1044 | |
| SRP193095 | UPF2 | 26019 | RNAseq | -0.1088 | 0.1574 | |
| SRP219564 | UPF2 | 26019 | RNAseq | -0.4207 | 0.0984 | |
| TCGA | UPF2 | 26019 | RNAseq | -0.0199 | 0.6913 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UPF2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UPF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UPF2 | 26019 | 6 | 7 | 17 | |
| GSE20123 | UPF2 | 26019 | 6 | 6 | 18 | |
| GSE43470 | UPF2 | 26019 | 3 | 5 | 35 | |
| GSE46452 | UPF2 | 26019 | 2 | 14 | 43 | |
| GSE47630 | UPF2 | 26019 | 6 | 14 | 20 | |
| GSE54993 | UPF2 | 26019 | 11 | 0 | 59 | |
| GSE54994 | UPF2 | 26019 | 4 | 9 | 40 | |
| GSE60625 | UPF2 | 26019 | 0 | 0 | 11 | |
| GSE74703 | UPF2 | 26019 | 2 | 3 | 31 | |
| GSE74704 | UPF2 | 26019 | 1 | 5 | 14 | |
| TCGA | UPF2 | 26019 | 19 | 24 | 53 |
Total number of gains: 60; Total number of losses: 87; Total Number of normals: 341.
Somatic mutations of UPF2:
Generating mutation plots.
Highly correlated genes for UPF2:
Showing top 20/77 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UPF2 | MYSM1 | 0.719258 | 3 | 0 | 3 |
| UPF2 | ACTR10 | 0.718628 | 3 | 0 | 3 |
| UPF2 | KANSL2 | 0.680728 | 3 | 0 | 3 |
| UPF2 | EIF3A | 0.668635 | 4 | 0 | 4 |
| UPF2 | MRPS16 | 0.660142 | 3 | 0 | 3 |
| UPF2 | LCOR | 0.654544 | 4 | 0 | 4 |
| UPF2 | BRD7 | 0.647703 | 3 | 0 | 3 |
| UPF2 | COA7 | 0.634246 | 3 | 0 | 3 |
| UPF2 | PPWD1 | 0.6178 | 4 | 0 | 3 |
| UPF2 | WDR92 | 0.615674 | 4 | 0 | 3 |
| UPF2 | HNRNPA1 | 0.612948 | 4 | 0 | 3 |
| UPF2 | ADNP | 0.610017 | 3 | 0 | 3 |
| UPF2 | CDC123 | 0.602788 | 9 | 0 | 6 |
| UPF2 | LARP7 | 0.599722 | 4 | 0 | 3 |
| UPF2 | EIF2B1 | 0.595258 | 3 | 0 | 3 |
| UPF2 | ZHX1 | 0.595163 | 3 | 0 | 3 |
| UPF2 | STK11IP | 0.590782 | 4 | 0 | 3 |
| UPF2 | NUP93 | 0.59029 | 4 | 0 | 3 |
| UPF2 | GCH1 | 0.586559 | 3 | 0 | 3 |
| UPF2 | NUP160 | 0.584205 | 3 | 0 | 3 |
For details and further investigation, click here
