| Full name: ephrin A3 | Alias Symbol: LERK3|Ehk1-L | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 1944 | HGNC ID: HGNC:3223 | Ensembl Gene: ENSG00000143590 | OMIM ID: 601381 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
EFNA3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa04015 | Rap1 signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04360 | Axon guidance |
Expression of EFNA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EFNA3 | 1944 | 210132_at | 0.1826 | 0.8458 | |
| GSE20347 | EFNA3 | 1944 | 210132_at | -0.2880 | 0.0361 | |
| GSE23400 | EFNA3 | 1944 | 210132_at | -0.0978 | 0.1037 | |
| GSE26886 | EFNA3 | 1944 | 210132_at | -0.0672 | 0.7491 | |
| GSE29001 | EFNA3 | 1944 | 210132_at | -0.2888 | 0.2350 | |
| GSE38129 | EFNA3 | 1944 | 210132_at | -0.0987 | 0.6943 | |
| GSE45670 | EFNA3 | 1944 | 210132_at | -0.0397 | 0.8266 | |
| GSE53622 | EFNA3 | 1944 | 32526 | -0.3233 | 0.0002 | |
| GSE53624 | EFNA3 | 1944 | 32526 | -0.3246 | 0.0000 | |
| GSE63941 | EFNA3 | 1944 | 210132_at | 1.3391 | 0.0011 | |
| GSE77861 | EFNA3 | 1944 | 210132_at | -0.1411 | 0.4520 | |
| GSE97050 | EFNA3 | 1944 | A_24_P114032 | -0.0125 | 0.9898 | |
| SRP007169 | EFNA3 | 1944 | RNAseq | -1.8296 | 0.0002 | |
| SRP064894 | EFNA3 | 1944 | RNAseq | -1.3876 | 0.0000 | |
| SRP133303 | EFNA3 | 1944 | RNAseq | -1.3189 | 0.0000 | |
| SRP159526 | EFNA3 | 1944 | RNAseq | -0.2990 | 0.5167 | |
| SRP219564 | EFNA3 | 1944 | RNAseq | -0.5071 | 0.6185 | |
| TCGA | EFNA3 | 1944 | RNAseq | 0.8050 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 3.
Survival by EFNA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EFNA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EFNA3 | 1944 | 14 | 0 | 16 | |
| GSE20123 | EFNA3 | 1944 | 13 | 0 | 17 | |
| GSE43470 | EFNA3 | 1944 | 6 | 2 | 35 | |
| GSE46452 | EFNA3 | 1944 | 2 | 1 | 56 | |
| GSE47630 | EFNA3 | 1944 | 14 | 0 | 26 | |
| GSE54993 | EFNA3 | 1944 | 0 | 4 | 66 | |
| GSE54994 | EFNA3 | 1944 | 16 | 0 | 37 | |
| GSE60625 | EFNA3 | 1944 | 0 | 0 | 11 | |
| GSE74703 | EFNA3 | 1944 | 6 | 1 | 29 | |
| GSE74704 | EFNA3 | 1944 | 6 | 0 | 14 | |
| TCGA | EFNA3 | 1944 | 38 | 2 | 56 |
Total number of gains: 115; Total number of losses: 10; Total Number of normals: 363.
Somatic mutations of EFNA3:
Generating mutation plots.
Highly correlated genes for EFNA3:
Showing top 20/659 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EFNA3 | ACSM5 | 0.766016 | 3 | 0 | 3 |
| EFNA3 | MMP17 | 0.753024 | 3 | 0 | 3 |
| EFNA3 | LKAAEAR1 | 0.739104 | 3 | 0 | 3 |
| EFNA3 | CD164L2 | 0.730972 | 3 | 0 | 3 |
| EFNA3 | KBTBD13 | 0.726708 | 3 | 0 | 3 |
| EFNA3 | GCM2 | 0.713334 | 4 | 0 | 4 |
| EFNA3 | COL20A1 | 0.712972 | 3 | 0 | 3 |
| EFNA3 | MFSD2B | 0.710676 | 3 | 0 | 3 |
| EFNA3 | RUFY4 | 0.69825 | 3 | 0 | 3 |
| EFNA3 | LRCH4 | 0.69796 | 3 | 0 | 3 |
| EFNA3 | IPO13 | 0.692166 | 4 | 0 | 3 |
| EFNA3 | ATP8B3 | 0.691469 | 5 | 0 | 4 |
| EFNA3 | ADAP1 | 0.69087 | 4 | 0 | 4 |
| EFNA3 | BRF1 | 0.684117 | 4 | 0 | 4 |
| EFNA3 | KIFC2 | 0.679467 | 5 | 0 | 4 |
| EFNA3 | RIMS4 | 0.676975 | 3 | 0 | 3 |
| EFNA3 | RNF126 | 0.66867 | 3 | 0 | 3 |
| EFNA3 | TEX13A | 0.668073 | 5 | 0 | 5 |
| EFNA3 | ERICH4 | 0.665513 | 3 | 0 | 3 |
| EFNA3 | MAPK8IP2 | 0.665097 | 4 | 0 | 4 |
For details and further investigation, click here
