| Full name: synaptotagmin 1 | Alias Symbol: P65 | ||
| Type: protein-coding gene | Cytoband: 12q21.2 | ||
| Entrez ID: 6857 | HGNC ID: HGNC:11509 | Ensembl Gene: ENSG00000067715 | OMIM ID: 185605 |
| Drug and gene relationship at DGIdb | |||
Expression of SYT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SYT1 | 6857 | 203999_at | 0.9273 | 0.3202 | |
| GSE20347 | SYT1 | 6857 | 203999_at | 0.8186 | 0.0001 | |
| GSE23400 | SYT1 | 6857 | 203999_at | 0.1342 | 0.0792 | |
| GSE26886 | SYT1 | 6857 | 203999_at | 3.3716 | 0.0000 | |
| GSE29001 | SYT1 | 6857 | 203999_at | 0.8430 | 0.0089 | |
| GSE38129 | SYT1 | 6857 | 203999_at | 0.7000 | 0.0456 | |
| GSE45670 | SYT1 | 6857 | 203999_at | 0.9916 | 0.0320 | |
| GSE53622 | SYT1 | 6857 | 88199 | 0.2538 | 0.0016 | |
| GSE53624 | SYT1 | 6857 | 88199 | 0.2300 | 0.1263 | |
| GSE63941 | SYT1 | 6857 | 203999_at | 2.1786 | 0.0475 | |
| GSE77861 | SYT1 | 6857 | 203999_at | 1.1905 | 0.0226 | |
| GSE97050 | SYT1 | 6857 | A_33_P3237201 | 0.0172 | 0.9469 | |
| SRP007169 | SYT1 | 6857 | RNAseq | 6.8078 | 0.0000 | |
| SRP008496 | SYT1 | 6857 | RNAseq | 5.3405 | 0.0000 | |
| SRP133303 | SYT1 | 6857 | RNAseq | 1.8759 | 0.0000 | |
| SRP159526 | SYT1 | 6857 | RNAseq | 3.1289 | 0.0000 | |
| SRP219564 | SYT1 | 6857 | RNAseq | 0.1370 | 0.8823 | |
| TCGA | SYT1 | 6857 | RNAseq | 0.3156 | 0.2066 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by SYT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SYT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SYT1 | 6857 | 4 | 3 | 23 | |
| GSE20123 | SYT1 | 6857 | 4 | 3 | 23 | |
| GSE43470 | SYT1 | 6857 | 3 | 1 | 39 | |
| GSE46452 | SYT1 | 6857 | 8 | 1 | 50 | |
| GSE47630 | SYT1 | 6857 | 10 | 1 | 29 | |
| GSE54993 | SYT1 | 6857 | 0 | 5 | 65 | |
| GSE54994 | SYT1 | 6857 | 7 | 1 | 45 | |
| GSE60625 | SYT1 | 6857 | 0 | 0 | 11 | |
| GSE74703 | SYT1 | 6857 | 3 | 1 | 32 | |
| GSE74704 | SYT1 | 6857 | 2 | 2 | 16 | |
| TCGA | SYT1 | 6857 | 15 | 14 | 67 |
Total number of gains: 56; Total number of losses: 32; Total Number of normals: 400.
Somatic mutations of SYT1:
Generating mutation plots.
Highly correlated genes for SYT1:
Showing top 20/339 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SYT1 | CYSTM1 | 0.7894 | 3 | 0 | 3 |
| SYT1 | OR2T27 | 0.778237 | 3 | 0 | 3 |
| SYT1 | LGALS12 | 0.770011 | 3 | 0 | 3 |
| SYT1 | TXNDC2 | 0.762279 | 3 | 0 | 3 |
| SYT1 | PSMB11 | 0.76111 | 3 | 0 | 3 |
| SYT1 | LOXL1-AS1 | 0.755658 | 3 | 0 | 3 |
| SYT1 | GPHA2 | 0.753549 | 3 | 0 | 3 |
| SYT1 | STRC | 0.75061 | 3 | 0 | 3 |
| SYT1 | S100A5 | 0.745702 | 3 | 0 | 3 |
| SYT1 | OR5A1 | 0.742373 | 3 | 0 | 3 |
| SYT1 | C9orf153 | 0.734421 | 3 | 0 | 3 |
| SYT1 | CPAMD8 | 0.732406 | 3 | 0 | 3 |
| SYT1 | DCDC1 | 0.732196 | 3 | 0 | 3 |
| SYT1 | GOLM1 | 0.731265 | 5 | 0 | 5 |
| SYT1 | SDK1 | 0.725738 | 3 | 0 | 3 |
| SYT1 | BSX | 0.724332 | 3 | 0 | 3 |
| SYT1 | OR2A5 | 0.721692 | 3 | 0 | 3 |
| SYT1 | TOR2A | 0.720329 | 3 | 0 | 3 |
| SYT1 | ATCAY | 0.711223 | 4 | 0 | 4 |
| SYT1 | GTF3C5 | 0.710144 | 3 | 0 | 3 |
For details and further investigation, click here
