| Full name: CD70 molecule | Alias Symbol: CD27L | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 970 | HGNC ID: HGNC:11937 | Ensembl Gene: | OMIM ID: 602840 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CD70:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD70 | 970 | 206508_at | 0.2888 | 0.2968 | |
| GSE20347 | CD70 | 970 | 206508_at | 0.1818 | 0.2656 | |
| GSE23400 | CD70 | 970 | 206508_at | 0.1107 | 0.1332 | |
| GSE26886 | CD70 | 970 | 206508_at | 0.2064 | 0.0327 | |
| GSE29001 | CD70 | 970 | 206508_at | 0.0749 | 0.6610 | |
| GSE38129 | CD70 | 970 | 206508_at | 0.2147 | 0.1911 | |
| GSE45670 | CD70 | 970 | 206508_at | 0.1557 | 0.4884 | |
| GSE63941 | CD70 | 970 | 206508_at | 0.9108 | 0.1162 | |
| GSE77861 | CD70 | 970 | 206508_at | -0.0441 | 0.7179 | |
| GSE97050 | CD70 | 970 | A_33_P3243449 | -0.1605 | 0.7085 | |
| SRP007169 | CD70 | 970 | RNAseq | 1.0795 | 0.1010 | |
| SRP064894 | CD70 | 970 | RNAseq | 0.3742 | 0.1187 | |
| SRP133303 | CD70 | 970 | RNAseq | 0.2112 | 0.0833 | |
| SRP193095 | CD70 | 970 | RNAseq | 0.4337 | 0.0051 | |
| SRP219564 | CD70 | 970 | RNAseq | 2.2095 | 0.0029 | |
| TCGA | CD70 | 970 | RNAseq | 1.6977 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by CD70 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CD70:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD70 | 970 | 5 | 3 | 22 | |
| GSE20123 | CD70 | 970 | 4 | 2 | 24 | |
| GSE43470 | CD70 | 970 | 2 | 6 | 35 | |
| GSE46452 | CD70 | 970 | 47 | 1 | 11 | |
| GSE47630 | CD70 | 970 | 5 | 7 | 28 | |
| GSE54993 | CD70 | 970 | 16 | 3 | 51 | |
| GSE54994 | CD70 | 970 | 6 | 14 | 33 | |
| GSE60625 | CD70 | 970 | 9 | 0 | 2 | |
| GSE74703 | CD70 | 970 | 2 | 4 | 30 | |
| GSE74704 | CD70 | 970 | 1 | 2 | 17 | |
| TCGA | CD70 | 970 | 9 | 19 | 68 |
Total number of gains: 106; Total number of losses: 61; Total Number of normals: 321.
Somatic mutations of CD70:
Generating mutation plots.
Highly correlated genes for CD70:
Showing top 20/261 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD70 | ADCK5 | 0.738669 | 3 | 0 | 3 |
| CD70 | CELF4 | 0.733389 | 3 | 0 | 3 |
| CD70 | C16orf95 | 0.730115 | 3 | 0 | 3 |
| CD70 | G6PD | 0.712841 | 3 | 0 | 3 |
| CD70 | RIMS4 | 0.709655 | 4 | 0 | 4 |
| CD70 | C7orf61 | 0.705195 | 3 | 0 | 3 |
| CD70 | BEST3 | 0.704619 | 3 | 0 | 3 |
| CD70 | GMIP | 0.702084 | 3 | 0 | 3 |
| CD70 | IGSF9B | 0.686879 | 3 | 0 | 3 |
| CD70 | ZNF524 | 0.684245 | 3 | 0 | 3 |
| CD70 | FBLL1 | 0.682108 | 3 | 0 | 3 |
| CD70 | INF2 | 0.680165 | 5 | 0 | 5 |
| CD70 | BRF1 | 0.679126 | 4 | 0 | 4 |
| CD70 | CA6 | 0.677632 | 3 | 0 | 3 |
| CD70 | UPB1 | 0.676268 | 4 | 0 | 3 |
| CD70 | DOHH | 0.67312 | 4 | 0 | 3 |
| CD70 | SLC35F3 | 0.672902 | 3 | 0 | 3 |
| CD70 | CABP1 | 0.671747 | 3 | 0 | 3 |
| CD70 | CDH4 | 0.669572 | 4 | 0 | 4 |
| CD70 | GABRD | 0.668158 | 4 | 0 | 4 |
For details and further investigation, click here
