| Full name: growth hormone secretagogue receptor | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q26.31 | ||
| Entrez ID: 2693 | HGNC ID: HGNC:4267 | Ensembl Gene: ENSG00000121853 | OMIM ID: 601898 |
| Drug and gene relationship at DGIdb | |||
GHSR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway |
Expression of GHSR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GHSR | 2693 | 224554_at | 0.1631 | 0.5840 | |
| GSE20347 | GHSR | 2693 | 221360_s_at | -0.0203 | 0.8030 | |
| GSE23400 | GHSR | 2693 | 221360_s_at | -0.0372 | 0.3036 | |
| GSE26886 | GHSR | 2693 | 224554_at | 0.1353 | 0.2346 | |
| GSE29001 | GHSR | 2693 | 221360_s_at | -0.0239 | 0.8880 | |
| GSE38129 | GHSR | 2693 | 221360_s_at | -0.0873 | 0.1622 | |
| GSE45670 | GHSR | 2693 | 224554_at | 0.0319 | 0.7393 | |
| GSE53622 | GHSR | 2693 | 48673 | 0.7520 | 0.0000 | |
| GSE53624 | GHSR | 2693 | 48673 | 0.2853 | 0.0331 | |
| GSE63941 | GHSR | 2693 | 224554_at | -0.1651 | 0.1490 | |
| GSE77861 | GHSR | 2693 | 224554_at | 0.0570 | 0.6478 | |
| GSE97050 | GHSR | 2693 | A_33_P3261620 | 0.0147 | 0.9524 | |
| TCGA | GHSR | 2693 | RNAseq | -0.0758 | 0.9667 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GHSR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GHSR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GHSR | 2693 | 24 | 0 | 6 | |
| GSE20123 | GHSR | 2693 | 24 | 0 | 6 | |
| GSE43470 | GHSR | 2693 | 23 | 0 | 20 | |
| GSE46452 | GHSR | 2693 | 19 | 1 | 39 | |
| GSE47630 | GHSR | 2693 | 27 | 2 | 11 | |
| GSE54993 | GHSR | 2693 | 1 | 15 | 54 | |
| GSE54994 | GHSR | 2693 | 41 | 0 | 12 | |
| GSE60625 | GHSR | 2693 | 0 | 6 | 5 | |
| GSE74703 | GHSR | 2693 | 19 | 0 | 17 | |
| GSE74704 | GHSR | 2693 | 16 | 0 | 4 | |
| TCGA | GHSR | 2693 | 80 | 0 | 16 |
Total number of gains: 274; Total number of losses: 24; Total Number of normals: 190.
Somatic mutations of GHSR:
Generating mutation plots.
Highly correlated genes for GHSR:
Showing top 20/493 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GHSR | C9orf153 | 0.832838 | 3 | 0 | 3 |
| GHSR | KRTAP10-12 | 0.83178 | 3 | 0 | 3 |
| GHSR | TMEM105 | 0.825907 | 3 | 0 | 3 |
| GHSR | STRC | 0.816059 | 3 | 0 | 3 |
| GHSR | F2RL3 | 0.813141 | 4 | 0 | 4 |
| GHSR | ZNF527 | 0.801563 | 3 | 0 | 3 |
| GHSR | SIGLEC11 | 0.792604 | 3 | 0 | 3 |
| GHSR | TCTE1 | 0.785 | 3 | 0 | 3 |
| GHSR | PRDM13 | 0.782915 | 3 | 0 | 3 |
| GHSR | YY2 | 0.778231 | 3 | 0 | 3 |
| GHSR | SYCN | 0.775963 | 3 | 0 | 3 |
| GHSR | PLA2G2C | 0.775386 | 3 | 0 | 3 |
| GHSR | LINC00862 | 0.772616 | 3 | 0 | 3 |
| GHSR | PROCA1 | 0.769551 | 3 | 0 | 3 |
| GHSR | LBX2 | 0.769234 | 3 | 0 | 3 |
| GHSR | C4BPA | 0.761519 | 3 | 0 | 3 |
| GHSR | BLACE | 0.757864 | 3 | 0 | 3 |
| GHSR | SHISA7 | 0.754017 | 3 | 0 | 3 |
| GHSR | MRGPRG | 0.753556 | 3 | 0 | 3 |
| GHSR | OR2A5 | 0.75215 | 3 | 0 | 3 |
For details and further investigation, click here
