| Full name: capping actin protein of muscle Z-line subunit alpha 2 | Alias Symbol: CAPZ|CAPPA2 | ||
| Type: protein-coding gene | Cytoband: 7q31.2 | ||
| Entrez ID: 830 | HGNC ID: HGNC:1490 | Ensembl Gene: ENSG00000198898 | OMIM ID: 601571 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CAPZA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CAPZA2 | 830 | 201238_s_at | -0.6557 | 0.1030 | |
| GSE20347 | CAPZA2 | 830 | 201238_s_at | -0.2887 | 0.2371 | |
| GSE23400 | CAPZA2 | 830 | 201238_s_at | -0.0841 | 0.4072 | |
| GSE26886 | CAPZA2 | 830 | 201238_s_at | -0.8966 | 0.0003 | |
| GSE29001 | CAPZA2 | 830 | 201237_at | -0.1263 | 0.7458 | |
| GSE38129 | CAPZA2 | 830 | 201238_s_at | -0.2604 | 0.1381 | |
| GSE45670 | CAPZA2 | 830 | 201238_s_at | -0.1994 | 0.0919 | |
| GSE53622 | CAPZA2 | 830 | 7955 | -0.1405 | 0.0121 | |
| GSE53624 | CAPZA2 | 830 | 7955 | -0.2354 | 0.0002 | |
| GSE63941 | CAPZA2 | 830 | 201238_s_at | -1.0275 | 0.0262 | |
| GSE77861 | CAPZA2 | 830 | 201238_s_at | -0.1497 | 0.5142 | |
| GSE97050 | CAPZA2 | 830 | A_32_P224666 | -0.0650 | 0.8254 | |
| SRP007169 | CAPZA2 | 830 | RNAseq | -0.5311 | 0.0809 | |
| SRP008496 | CAPZA2 | 830 | RNAseq | -0.2239 | 0.2428 | |
| SRP064894 | CAPZA2 | 830 | RNAseq | -0.1274 | 0.4205 | |
| SRP133303 | CAPZA2 | 830 | RNAseq | 0.2860 | 0.0302 | |
| SRP159526 | CAPZA2 | 830 | RNAseq | -0.4782 | 0.1732 | |
| SRP193095 | CAPZA2 | 830 | RNAseq | -0.4669 | 0.0010 | |
| SRP219564 | CAPZA2 | 830 | RNAseq | -0.4492 | 0.2737 | |
| TCGA | CAPZA2 | 830 | RNAseq | -0.1096 | 0.0203 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CAPZA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CAPZA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CAPZA2 | 830 | 9 | 2 | 19 | |
| GSE20123 | CAPZA2 | 830 | 10 | 2 | 18 | |
| GSE43470 | CAPZA2 | 830 | 3 | 2 | 38 | |
| GSE46452 | CAPZA2 | 830 | 8 | 1 | 50 | |
| GSE47630 | CAPZA2 | 830 | 7 | 4 | 29 | |
| GSE54993 | CAPZA2 | 830 | 2 | 7 | 61 | |
| GSE54994 | CAPZA2 | 830 | 11 | 5 | 37 | |
| GSE60625 | CAPZA2 | 830 | 0 | 0 | 11 | |
| GSE74703 | CAPZA2 | 830 | 3 | 2 | 31 | |
| GSE74704 | CAPZA2 | 830 | 7 | 2 | 11 | |
| TCGA | CAPZA2 | 830 | 33 | 17 | 46 |
Total number of gains: 93; Total number of losses: 44; Total Number of normals: 351.
Somatic mutations of CAPZA2:
Generating mutation plots.
Highly correlated genes for CAPZA2:
Showing top 20/881 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CAPZA2 | SORT1 | 0.80673 | 3 | 0 | 3 |
| CAPZA2 | CYYR1 | 0.788843 | 4 | 0 | 4 |
| CAPZA2 | TET2 | 0.771073 | 3 | 0 | 3 |
| CAPZA2 | PIGN | 0.767795 | 3 | 0 | 3 |
| CAPZA2 | ID4 | 0.766015 | 3 | 0 | 3 |
| CAPZA2 | STT3B | 0.749531 | 3 | 0 | 3 |
| CAPZA2 | KAT7 | 0.735714 | 3 | 0 | 3 |
| CAPZA2 | SLC2A13 | 0.735566 | 3 | 0 | 3 |
| CAPZA2 | SENP8 | 0.73494 | 4 | 0 | 4 |
| CAPZA2 | GRAMD1C | 0.731721 | 3 | 0 | 3 |
| CAPZA2 | ERI2 | 0.727258 | 3 | 0 | 3 |
| CAPZA2 | EBF3 | 0.726164 | 4 | 0 | 3 |
| CAPZA2 | CCNDBP1 | 0.724121 | 5 | 0 | 5 |
| CAPZA2 | CHIC2 | 0.721791 | 4 | 0 | 4 |
| CAPZA2 | CMTR2 | 0.720645 | 3 | 0 | 3 |
| CAPZA2 | FBXO8 | 0.71612 | 6 | 0 | 5 |
| CAPZA2 | FBXL3 | 0.715528 | 5 | 0 | 5 |
| CAPZA2 | GAB3 | 0.714266 | 3 | 0 | 3 |
| CAPZA2 | SYTL4 | 0.711277 | 3 | 0 | 3 |
| CAPZA2 | FAM13C | 0.710605 | 4 | 0 | 3 |
For details and further investigation, click here
