| Full name: tet methylcytosine dioxygenase 2 | Alias Symbol: FLJ20032 | ||
| Type: protein-coding gene | Cytoband: 4q24 | ||
| Entrez ID: 54790 | HGNC ID: HGNC:25941 | Ensembl Gene: ENSG00000168769 | OMIM ID: 612839 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TET2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TET2 | 54790 | 227624_at | 0.1214 | 0.9069 | |
| GSE26886 | TET2 | 54790 | 227624_at | -1.4141 | 0.0004 | |
| GSE45670 | TET2 | 54790 | 227624_at | -0.4003 | 0.0306 | |
| GSE53622 | TET2 | 54790 | 94606 | -0.4164 | 0.0000 | |
| GSE53624 | TET2 | 54790 | 94606 | -0.5675 | 0.0000 | |
| GSE63941 | TET2 | 54790 | 227624_at | 0.2404 | 0.6722 | |
| GSE77861 | TET2 | 54790 | 227624_at | -0.3776 | 0.2034 | |
| GSE97050 | TET2 | 54790 | A_33_P3238685 | -0.1045 | 0.6250 | |
| SRP007169 | TET2 | 54790 | RNAseq | -1.1256 | 0.0030 | |
| SRP008496 | TET2 | 54790 | RNAseq | -1.0331 | 0.0000 | |
| SRP064894 | TET2 | 54790 | RNAseq | -1.1848 | 0.0000 | |
| SRP133303 | TET2 | 54790 | RNAseq | -0.1574 | 0.1744 | |
| SRP159526 | TET2 | 54790 | RNAseq | -0.8696 | 0.0000 | |
| SRP193095 | TET2 | 54790 | RNAseq | -0.6275 | 0.0000 | |
| SRP219564 | TET2 | 54790 | RNAseq | -0.9804 | 0.0367 | |
| TCGA | TET2 | 54790 | RNAseq | 0.0599 | 0.3693 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by TET2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TET2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TET2 | 54790 | 0 | 12 | 18 | |
| GSE20123 | TET2 | 54790 | 0 | 12 | 18 | |
| GSE43470 | TET2 | 54790 | 0 | 13 | 30 | |
| GSE46452 | TET2 | 54790 | 1 | 36 | 22 | |
| GSE47630 | TET2 | 54790 | 0 | 20 | 20 | |
| GSE54993 | TET2 | 54790 | 9 | 0 | 61 | |
| GSE54994 | TET2 | 54790 | 1 | 10 | 42 | |
| GSE60625 | TET2 | 54790 | 0 | 3 | 8 | |
| GSE74703 | TET2 | 54790 | 0 | 11 | 25 | |
| GSE74704 | TET2 | 54790 | 0 | 6 | 14 | |
| TCGA | TET2 | 54790 | 7 | 38 | 51 |
Total number of gains: 18; Total number of losses: 161; Total Number of normals: 309.
Somatic mutations of TET2:
Generating mutation plots.
Highly correlated genes for TET2:
Showing top 20/1228 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TET2 | CLEC16A | 0.795402 | 3 | 0 | 3 |
| TET2 | ACTR2 | 0.794167 | 3 | 0 | 3 |
| TET2 | ALG6 | 0.79228 | 3 | 0 | 3 |
| TET2 | ASH2L | 0.789334 | 3 | 0 | 3 |
| TET2 | PEX11B | 0.787439 | 5 | 0 | 5 |
| TET2 | WDR77 | 0.784573 | 3 | 0 | 3 |
| TET2 | PDCD6 | 0.772312 | 3 | 0 | 3 |
| TET2 | CAPZA2 | 0.771073 | 3 | 0 | 3 |
| TET2 | SYPL1 | 0.768 | 4 | 0 | 4 |
| TET2 | LYSMD3 | 0.767781 | 3 | 0 | 3 |
| TET2 | USP38 | 0.764327 | 5 | 0 | 4 |
| TET2 | PIK3C3 | 0.763021 | 3 | 0 | 3 |
| TET2 | DDI2 | 0.762829 | 3 | 0 | 3 |
| TET2 | LY75 | 0.761709 | 3 | 0 | 3 |
| TET2 | YIPF4 | 0.758617 | 3 | 0 | 3 |
| TET2 | FRS2 | 0.758603 | 3 | 0 | 3 |
| TET2 | DCTD | 0.755258 | 3 | 0 | 3 |
| TET2 | RBM20 | 0.754515 | 4 | 0 | 4 |
| TET2 | SMARCA4 | 0.754487 | 3 | 0 | 3 |
| TET2 | ARID5B | 0.753723 | 3 | 0 | 3 |
For details and further investigation, click here
