| Full name: SUMO peptidase family member, NEDD8 specific | Alias Symbol: NEDP1|DEN1|HsT17512 | ||
| Type: protein-coding gene | Cytoband: 15q23 | ||
| Entrez ID: 123228 | HGNC ID: HGNC:22992 | Ensembl Gene: ENSG00000166192 | OMIM ID: 608659 |
| Drug and gene relationship at DGIdb | |||
Expression of SENP8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SENP8 | 123228 | 228398_at | -0.3325 | 0.5449 | |
| GSE26886 | SENP8 | 123228 | 228398_at | -0.8256 | 0.0011 | |
| GSE45670 | SENP8 | 123228 | 228398_at | 0.0587 | 0.7860 | |
| GSE53622 | SENP8 | 123228 | 76309 | -0.2742 | 0.0029 | |
| GSE53624 | SENP8 | 123228 | 76309 | -0.3399 | 0.0032 | |
| GSE63941 | SENP8 | 123228 | 228398_at | 0.3159 | 0.5485 | |
| GSE77861 | SENP8 | 123228 | 228398_at | -0.2163 | 0.1927 | |
| GSE97050 | SENP8 | 123228 | A_23_P334263 | -0.2679 | 0.2151 | |
| SRP007169 | SENP8 | 123228 | RNAseq | -0.6711 | 0.2828 | |
| SRP008496 | SENP8 | 123228 | RNAseq | -0.9066 | 0.0263 | |
| SRP064894 | SENP8 | 123228 | RNAseq | -0.5722 | 0.0035 | |
| SRP133303 | SENP8 | 123228 | RNAseq | -0.1435 | 0.2793 | |
| SRP159526 | SENP8 | 123228 | RNAseq | -0.6675 | 0.0470 | |
| SRP193095 | SENP8 | 123228 | RNAseq | -0.2823 | 0.0136 | |
| SRP219564 | SENP8 | 123228 | RNAseq | -0.0747 | 0.8385 | |
| TCGA | SENP8 | 123228 | RNAseq | -0.4078 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SENP8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SENP8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SENP8 | 123228 | 7 | 1 | 22 | |
| GSE20123 | SENP8 | 123228 | 7 | 1 | 22 | |
| GSE43470 | SENP8 | 123228 | 4 | 6 | 33 | |
| GSE46452 | SENP8 | 123228 | 3 | 7 | 49 | |
| GSE47630 | SENP8 | 123228 | 8 | 10 | 22 | |
| GSE54993 | SENP8 | 123228 | 5 | 6 | 59 | |
| GSE54994 | SENP8 | 123228 | 5 | 8 | 40 | |
| GSE60625 | SENP8 | 123228 | 4 | 4 | 3 | |
| GSE74703 | SENP8 | 123228 | 4 | 3 | 29 | |
| GSE74704 | SENP8 | 123228 | 3 | 1 | 16 | |
| TCGA | SENP8 | 123228 | 12 | 15 | 69 |
Total number of gains: 62; Total number of losses: 62; Total Number of normals: 364.
Somatic mutations of SENP8:
Generating mutation plots.
Highly correlated genes for SENP8:
Showing top 20/620 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SENP8 | PUM2 | 0.826606 | 3 | 0 | 3 |
| SENP8 | UBR2 | 0.824606 | 3 | 0 | 3 |
| SENP8 | TACC1 | 0.80674 | 3 | 0 | 3 |
| SENP8 | IREB2 | 0.775962 | 3 | 0 | 3 |
| SENP8 | CUL1 | 0.764904 | 3 | 0 | 3 |
| SENP8 | RORA | 0.763512 | 3 | 0 | 3 |
| SENP8 | GLUD2 | 0.761483 | 3 | 0 | 3 |
| SENP8 | MTUS1 | 0.758648 | 3 | 0 | 3 |
| SENP8 | EI24 | 0.752662 | 3 | 0 | 3 |
| SENP8 | RBM7 | 0.751749 | 5 | 0 | 5 |
| SENP8 | FUNDC2 | 0.747341 | 3 | 0 | 3 |
| SENP8 | ZFAND5 | 0.740906 | 3 | 0 | 3 |
| SENP8 | OGFRL1 | 0.738262 | 3 | 0 | 3 |
| SENP8 | BCLAF1 | 0.735045 | 3 | 0 | 3 |
| SENP8 | CAPZA2 | 0.73494 | 4 | 0 | 4 |
| SENP8 | HIPK1 | 0.731249 | 4 | 0 | 3 |
| SENP8 | PNKD | 0.730547 | 4 | 0 | 3 |
| SENP8 | KRAS | 0.7305 | 3 | 0 | 3 |
| SENP8 | RPS24 | 0.730344 | 3 | 0 | 3 |
| SENP8 | CUL4B | 0.728636 | 5 | 0 | 4 |
For details and further investigation, click here
