| Full name: caspase recruitment domain family member 9 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 9q34.3 | ||
| Entrez ID: 64170 | HGNC ID: HGNC:16391 | Ensembl Gene: ENSG00000187796 | OMIM ID: 607212 |
| Drug and gene relationship at DGIdb | |||
CARD9 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04621 | NOD-like receptor signaling pathway | |
| hsa05152 | Tuberculosis |
Expression of CARD9:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | CARD9 | 64170 | 120020 | -0.2334 | 0.0053 | |
| GSE53624 | CARD9 | 64170 | 95020 | -0.5557 | 0.0000 | |
| GSE97050 | CARD9 | 64170 | A_33_P3389573 | 0.2221 | 0.4230 | |
| SRP064894 | CARD9 | 64170 | RNAseq | 0.2321 | 0.4558 | |
| SRP133303 | CARD9 | 64170 | RNAseq | -0.1872 | 0.5117 | |
| SRP159526 | CARD9 | 64170 | RNAseq | -0.6684 | 0.0542 | |
| SRP193095 | CARD9 | 64170 | RNAseq | -0.6995 | 0.0005 | |
| SRP219564 | CARD9 | 64170 | RNAseq | 0.2874 | 0.5725 | |
| TCGA | CARD9 | 64170 | RNAseq | 0.9532 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CARD9 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CARD9:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CARD9 | 64170 | 4 | 7 | 19 | |
| GSE20123 | CARD9 | 64170 | 4 | 7 | 19 | |
| GSE43470 | CARD9 | 64170 | 3 | 7 | 33 | |
| GSE46452 | CARD9 | 64170 | 6 | 13 | 40 | |
| GSE47630 | CARD9 | 64170 | 6 | 15 | 19 | |
| GSE54993 | CARD9 | 64170 | 3 | 3 | 64 | |
| GSE54994 | CARD9 | 64170 | 13 | 7 | 33 | |
| GSE60625 | CARD9 | 64170 | 0 | 0 | 11 | |
| GSE74703 | CARD9 | 64170 | 3 | 5 | 28 | |
| GSE74704 | CARD9 | 64170 | 2 | 5 | 13 | |
| TCGA | CARD9 | 64170 | 29 | 24 | 43 |
Total number of gains: 73; Total number of losses: 93; Total Number of normals: 322.
Somatic mutations of CARD9:
Generating mutation plots.
Highly correlated genes for CARD9:
Showing all 14 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CARD9 | PLD4 | 0.701227 | 3 | 0 | 3 |
| CARD9 | TMIGD2 | 0.684804 | 3 | 0 | 3 |
| CARD9 | CD48 | 0.65715 | 3 | 0 | 3 |
| CARD9 | NLRC3 | 0.649378 | 3 | 0 | 3 |
| CARD9 | LYL1 | 0.624333 | 3 | 0 | 3 |
| CARD9 | CD247 | 0.624131 | 4 | 0 | 3 |
| CARD9 | IL10RA | 0.624036 | 3 | 0 | 3 |
| CARD9 | CXorf21 | 0.612929 | 3 | 0 | 3 |
| CARD9 | CHI3L2 | 0.611156 | 3 | 0 | 3 |
| CARD9 | SIGLEC10 | 0.593977 | 3 | 0 | 3 |
| CARD9 | CD52 | 0.568459 | 4 | 0 | 3 |
| CARD9 | DOCK2 | 0.568375 | 4 | 0 | 3 |
| CARD9 | MFNG | 0.557408 | 4 | 0 | 3 |
| CARD9 | CLEC10A | 0.549241 | 3 | 0 | 3 |
For details and further investigation, click here
