| Full name: sialic acid binding Ig like lectin 10 | Alias Symbol: SIGLEC-10|SLG2|PRO940|MGC126774 | ||
| Type: protein-coding gene | Cytoband: 19q13.41 | ||
| Entrez ID: 89790 | HGNC ID: HGNC:15620 | Ensembl Gene: ENSG00000142512 | OMIM ID: 606091 |
| Drug and gene relationship at DGIdb | |||
Expression of SIGLEC10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIGLEC10 | 89790 | 1552807_a_at | 0.5839 | 0.5859 | |
| GSE26886 | SIGLEC10 | 89790 | 1552807_a_at | -0.0691 | 0.8695 | |
| GSE45670 | SIGLEC10 | 89790 | 1552807_a_at | 0.2188 | 0.4187 | |
| GSE53622 | SIGLEC10 | 89790 | 23093 | 0.6060 | 0.0005 | |
| GSE53624 | SIGLEC10 | 89790 | 23093 | 0.2699 | 0.0762 | |
| GSE63941 | SIGLEC10 | 89790 | 1552807_a_at | 0.0361 | 0.7781 | |
| GSE77861 | SIGLEC10 | 89790 | 1552806_a_at | -0.1963 | 0.1382 | |
| GSE97050 | SIGLEC10 | 89790 | A_23_P208182 | 0.4018 | 0.2192 | |
| SRP007169 | SIGLEC10 | 89790 | RNAseq | 0.6889 | 0.1985 | |
| SRP008496 | SIGLEC10 | 89790 | RNAseq | 0.3697 | 0.3364 | |
| SRP064894 | SIGLEC10 | 89790 | RNAseq | 0.8759 | 0.0000 | |
| SRP133303 | SIGLEC10 | 89790 | RNAseq | 0.3619 | 0.0022 | |
| SRP159526 | SIGLEC10 | 89790 | RNAseq | -0.2187 | 0.7112 | |
| SRP193095 | SIGLEC10 | 89790 | RNAseq | 0.2742 | 0.0314 | |
| SRP219564 | SIGLEC10 | 89790 | RNAseq | 0.8504 | 0.1686 | |
| TCGA | SIGLEC10 | 89790 | RNAseq | 0.5913 | 0.0014 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SIGLEC10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIGLEC10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIGLEC10 | 89790 | 3 | 4 | 23 | |
| GSE20123 | SIGLEC10 | 89790 | 3 | 3 | 24 | |
| GSE43470 | SIGLEC10 | 89790 | 3 | 12 | 28 | |
| GSE46452 | SIGLEC10 | 89790 | 45 | 1 | 13 | |
| GSE47630 | SIGLEC10 | 89790 | 9 | 6 | 25 | |
| GSE54993 | SIGLEC10 | 89790 | 17 | 4 | 49 | |
| GSE54994 | SIGLEC10 | 89790 | 4 | 14 | 35 | |
| GSE60625 | SIGLEC10 | 89790 | 9 | 0 | 2 | |
| GSE74703 | SIGLEC10 | 89790 | 3 | 8 | 25 | |
| GSE74704 | SIGLEC10 | 89790 | 3 | 1 | 16 | |
| TCGA | SIGLEC10 | 89790 | 14 | 19 | 63 |
Total number of gains: 113; Total number of losses: 72; Total Number of normals: 303.
Somatic mutations of SIGLEC10:
Generating mutation plots.
Highly correlated genes for SIGLEC10:
Showing top 20/203 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIGLEC10 | GZMM | 0.780895 | 3 | 0 | 3 |
| SIGLEC10 | CYTIP | 0.733454 | 5 | 0 | 5 |
| SIGLEC10 | AIF1 | 0.73228 | 6 | 0 | 6 |
| SIGLEC10 | CD300LF | 0.730054 | 7 | 0 | 6 |
| SIGLEC10 | EVI2A | 0.727435 | 5 | 0 | 5 |
| SIGLEC10 | DOCK2 | 0.721251 | 8 | 0 | 8 |
| SIGLEC10 | CYBB | 0.716896 | 6 | 0 | 6 |
| SIGLEC10 | IL10RA | 0.71648 | 8 | 0 | 8 |
| SIGLEC10 | LAPTM5 | 0.715439 | 7 | 0 | 6 |
| SIGLEC10 | CORO1A | 0.712354 | 6 | 0 | 6 |
| SIGLEC10 | LYZ | 0.711052 | 3 | 0 | 3 |
| SIGLEC10 | CD3D | 0.705233 | 7 | 0 | 7 |
| SIGLEC10 | TLR8 | 0.700661 | 7 | 0 | 6 |
| SIGLEC10 | TBXAS1 | 0.695835 | 6 | 0 | 5 |
| SIGLEC10 | GPSM3 | 0.695273 | 4 | 0 | 4 |
| SIGLEC10 | LCK | 0.694255 | 6 | 0 | 5 |
| SIGLEC10 | CD28 | 0.694101 | 5 | 0 | 4 |
| SIGLEC10 | TYROBP | 0.690477 | 6 | 0 | 6 |
| SIGLEC10 | CD48 | 0.690331 | 8 | 0 | 7 |
| SIGLEC10 | ITGB2 | 0.689286 | 7 | 0 | 6 |
For details and further investigation, click here
