| Full name: LYL1 basic helix-loop-helix family member | Alias Symbol: bHLHa18 | ||
| Type: protein-coding gene | Cytoband: 19p13.13 | ||
| Entrez ID: 4066 | HGNC ID: HGNC:6734 | Ensembl Gene: ENSG00000104903 | OMIM ID: 151440 |
| Drug and gene relationship at DGIdb | |||
Expression of LYL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LYL1 | 4066 | 210044_s_at | 0.2132 | 0.6255 | |
| GSE20347 | LYL1 | 4066 | 210044_s_at | -0.1125 | 0.2744 | |
| GSE23400 | LYL1 | 4066 | 210044_s_at | -0.1457 | 0.0014 | |
| GSE26886 | LYL1 | 4066 | 210044_s_at | 0.5654 | 0.0013 | |
| GSE29001 | LYL1 | 4066 | 210044_s_at | 0.0924 | 0.6231 | |
| GSE38129 | LYL1 | 4066 | 210044_s_at | -0.2238 | 0.0328 | |
| GSE45670 | LYL1 | 4066 | 210044_s_at | -0.1544 | 0.1940 | |
| GSE53622 | LYL1 | 4066 | 93851 | -0.4500 | 0.0001 | |
| GSE53624 | LYL1 | 4066 | 93851 | -0.2781 | 0.0034 | |
| GSE63941 | LYL1 | 4066 | 210044_s_at | 0.2712 | 0.2108 | |
| GSE77861 | LYL1 | 4066 | 210044_s_at | 0.1134 | 0.3990 | |
| GSE97050 | LYL1 | 4066 | A_33_P3215422 | 0.2054 | 0.5245 | |
| SRP064894 | LYL1 | 4066 | RNAseq | 0.1301 | 0.7107 | |
| SRP133303 | LYL1 | 4066 | RNAseq | -0.6344 | 0.0197 | |
| SRP159526 | LYL1 | 4066 | RNAseq | -0.8444 | 0.0966 | |
| SRP219564 | LYL1 | 4066 | RNAseq | 0.1668 | 0.7936 | |
| TCGA | LYL1 | 4066 | RNAseq | -0.0418 | 0.7884 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LYL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LYL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LYL1 | 4066 | 4 | 2 | 24 | |
| GSE20123 | LYL1 | 4066 | 3 | 1 | 26 | |
| GSE43470 | LYL1 | 4066 | 2 | 6 | 35 | |
| GSE46452 | LYL1 | 4066 | 47 | 1 | 11 | |
| GSE47630 | LYL1 | 4066 | 4 | 7 | 29 | |
| GSE54993 | LYL1 | 4066 | 16 | 3 | 51 | |
| GSE54994 | LYL1 | 4066 | 6 | 13 | 34 | |
| GSE60625 | LYL1 | 4066 | 9 | 0 | 2 | |
| GSE74703 | LYL1 | 4066 | 2 | 4 | 30 | |
| GSE74704 | LYL1 | 4066 | 0 | 1 | 19 | |
| TCGA | LYL1 | 4066 | 18 | 13 | 65 |
Total number of gains: 111; Total number of losses: 51; Total Number of normals: 326.
Somatic mutations of LYL1:
Generating mutation plots.
Highly correlated genes for LYL1:
Showing top 20/344 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LYL1 | B3GAT3 | 0.766966 | 4 | 0 | 4 |
| LYL1 | BMF | 0.757254 | 4 | 0 | 4 |
| LYL1 | ZKSCAN2 | 0.752534 | 3 | 0 | 3 |
| LYL1 | GBX2 | 0.737313 | 3 | 0 | 3 |
| LYL1 | ALPL | 0.691691 | 4 | 0 | 4 |
| LYL1 | UBQLN3 | 0.669717 | 4 | 0 | 4 |
| LYL1 | GDPD5 | 0.666013 | 5 | 0 | 5 |
| LYL1 | MYO1A | 0.664598 | 3 | 0 | 3 |
| LYL1 | S100A5 | 0.66348 | 3 | 0 | 3 |
| LYL1 | PIP5KL1 | 0.661892 | 4 | 0 | 3 |
| LYL1 | C2orf81 | 0.659994 | 4 | 0 | 3 |
| LYL1 | C6orf226 | 0.65792 | 4 | 0 | 4 |
| LYL1 | MFNG | 0.654647 | 10 | 0 | 8 |
| LYL1 | BEST2 | 0.653618 | 5 | 0 | 4 |
| LYL1 | SELL | 0.652001 | 6 | 0 | 5 |
| LYL1 | EMID1 | 0.648216 | 5 | 0 | 4 |
| LYL1 | WDR34 | 0.647293 | 3 | 0 | 3 |
| LYL1 | ZNF366 | 0.644802 | 3 | 0 | 3 |
| LYL1 | CD52 | 0.644728 | 7 | 0 | 6 |
| LYL1 | AK8 | 0.644331 | 3 | 0 | 3 |
For details and further investigation, click here
