DOCK2

 

Full name: dedicator of cytokinesis 2 Alias Symbol: KIAA0209
Type: protein-coding gene Cytoband: 5q35.1
Entrez ID: 1794 HGNC ID: HGNC:2988 Ensembl Gene: ENSG00000134516 OMIM ID: 603122
Drug and gene relationship at DGIdb

 

DOCK2 involved pathways:

KEGG pathway Description View
hsa04062Chemokine signaling pathway
hsa04666Fc gamma R-mediated phagocytosis

 

Expression of DOCK2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DOCK2 1794 213160_at 0.0316 0.9874
GSE20347 DOCK2 1794 213160_at -0.0560 0.5921
GSE23400 DOCK2 1794 213160_at 0.0242 0.7310
GSE26886 DOCK2 1794 213160_at -0.1564 0.5840
GSE29001 DOCK2 1794 213160_at 0.0810 0.7728
GSE38129 DOCK2 1794 213160_at -0.0778 0.7987
GSE45670 DOCK2 1794 213160_at -0.5191 0.0819
GSE53622 DOCK2 1794 164413 -0.1117 0.4309
GSE53624 DOCK2 1794 18838 -0.5337 0.0058
GSE63941 DOCK2 1794 213160_at -1.3393 0.0117
GSE77861 DOCK2 1794 213160_at -0.1100 0.4825
GSE97050 DOCK2 1794 A_24_P408704 0.6488 0.2525
SRP007169 DOCK2 1794 RNAseq 1.7306 0.0146
SRP008496 DOCK2 1794 RNAseq 1.2195 0.0067
SRP064894 DOCK2 1794 RNAseq 0.3858 0.2105
SRP133303 DOCK2 1794 RNAseq -0.0511 0.8263
SRP159526 DOCK2 1794 RNAseq -0.6345 0.4643
SRP193095 DOCK2 1794 RNAseq 0.1149 0.6704
SRP219564 DOCK2 1794 RNAseq 0.8393 0.0880
TCGA DOCK2 1794 RNAseq -0.4311 0.0121

Upregulated datasets: 2; Downregulated datasets: 1.  

 

Survival by DOCK2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DOCK2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DOCK2 1794 1 13 16
GSE20123 DOCK2 1794 1 13 16
GSE43470 DOCK2 1794 1 9 33
GSE46452 DOCK2 1794 0 27 32
GSE47630 DOCK2 1794 0 20 20
GSE54993 DOCK2 1794 9 2 59
GSE54994 DOCK2 1794 2 15 36
GSE60625 DOCK2 1794 1 0 10
GSE74703 DOCK2 1794 1 6 29
GSE74704 DOCK2 1794 0 6 14
TCGA DOCK2 1794 7 36 53

Total number of gains: 23; Total number of losses: 147; Total Number of normals: 318.  

 

Somatic mutations of DOCK2:

 

Generating mutation plots.

 

Highly correlated genes for DOCK2:

 

Showing top 20/302 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DOCK2MPEG10.814775505
DOCK2C1orf1620.807007606
DOCK2CD530.802476808
DOCK2IRF80.79910910010
DOCK2CD280.794464505
DOCK2EVI2B0.77982111011
DOCK2IL10RA0.77383311011
DOCK2CD520.77155711011
DOCK2CORO1A0.76346810010
DOCK2ARHGAP150.756198303
DOCK2AKNA0.751303606
DOCK2PTPRC0.7495410010
DOCK2PARVG0.746155606
DOCK2ARHGDIB0.745704909
DOCK2CYTIP0.74381910010
DOCK2ITK0.742556909
DOCK2SNX200.739631606
DOCK2PIK3R50.737949505
DOCK2CD480.73644912011
DOCK2HLA-DMB0.72539911010

For details and further investigation, click here