| Full name: NLR family CARD domain containing 3 | Alias Symbol: CLR16.2|FLJ00348|NOD3 | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 197358 | HGNC ID: HGNC:29889 | Ensembl Gene: ENSG00000167984 | OMIM ID: 615648 |
| Drug and gene relationship at DGIdb | |||
Expression of NLRC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NLRC3 | 197358 | 236295_s_at | 0.2949 | 0.8473 | |
| GSE26886 | NLRC3 | 197358 | 236295_s_at | -0.6679 | 0.1395 | |
| GSE45670 | NLRC3 | 197358 | 236295_s_at | -0.0719 | 0.8653 | |
| GSE53622 | NLRC3 | 197358 | 1935 | -0.2916 | 0.0793 | |
| GSE53624 | NLRC3 | 197358 | 1935 | -0.4234 | 0.0004 | |
| GSE63941 | NLRC3 | 197358 | 236295_s_at | -0.0128 | 0.9503 | |
| GSE77861 | NLRC3 | 197358 | 236295_s_at | -0.1545 | 0.0791 | |
| GSE97050 | NLRC3 | 197358 | A_33_P3415859 | 0.0485 | 0.8505 | |
| SRP007169 | NLRC3 | 197358 | RNAseq | 0.2551 | 0.6447 | |
| SRP064894 | NLRC3 | 197358 | RNAseq | -0.3398 | 0.2140 | |
| SRP133303 | NLRC3 | 197358 | RNAseq | -0.4280 | 0.0494 | |
| SRP159526 | NLRC3 | 197358 | RNAseq | -0.8285 | 0.0990 | |
| SRP193095 | NLRC3 | 197358 | RNAseq | 0.1278 | 0.5582 | |
| SRP219564 | NLRC3 | 197358 | RNAseq | -0.1410 | 0.6537 | |
| TCGA | NLRC3 | 197358 | RNAseq | -0.1094 | 0.4847 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NLRC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NLRC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NLRC3 | 197358 | 5 | 5 | 20 | |
| GSE20123 | NLRC3 | 197358 | 5 | 4 | 21 | |
| GSE43470 | NLRC3 | 197358 | 4 | 7 | 32 | |
| GSE46452 | NLRC3 | 197358 | 38 | 1 | 20 | |
| GSE47630 | NLRC3 | 197358 | 13 | 6 | 21 | |
| GSE54993 | NLRC3 | 197358 | 4 | 5 | 61 | |
| GSE54994 | NLRC3 | 197358 | 5 | 9 | 39 | |
| GSE60625 | NLRC3 | 197358 | 4 | 0 | 7 | |
| GSE74703 | NLRC3 | 197358 | 4 | 5 | 27 | |
| GSE74704 | NLRC3 | 197358 | 3 | 2 | 15 | |
| TCGA | NLRC3 | 197358 | 19 | 14 | 63 |
Total number of gains: 104; Total number of losses: 58; Total Number of normals: 326.
Somatic mutations of NLRC3:
Generating mutation plots.
Highly correlated genes for NLRC3:
Showing top 20/107 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NLRC3 | TRAT1 | 0.761739 | 5 | 0 | 5 |
| NLRC3 | THEMIS | 0.761485 | 6 | 0 | 6 |
| NLRC3 | PTPRC | 0.742535 | 6 | 0 | 6 |
| NLRC3 | CD247 | 0.738572 | 8 | 0 | 7 |
| NLRC3 | EVI2A | 0.734157 | 4 | 0 | 4 |
| NLRC3 | TRAF3IP3 | 0.718277 | 7 | 0 | 6 |
| NLRC3 | CYTIP | 0.713575 | 5 | 0 | 5 |
| NLRC3 | EVI2B | 0.712143 | 7 | 0 | 7 |
| NLRC3 | CD48 | 0.700193 | 8 | 0 | 7 |
| NLRC3 | BTK | 0.692939 | 4 | 0 | 4 |
| NLRC3 | FAM71A | 0.684368 | 3 | 0 | 3 |
| NLRC3 | ITGAL | 0.681898 | 8 | 0 | 6 |
| NLRC3 | CD3G | 0.681616 | 7 | 0 | 6 |
| NLRC3 | IL10RA | 0.678625 | 7 | 0 | 7 |
| NLRC3 | PRKCB | 0.677025 | 6 | 0 | 5 |
| NLRC3 | CXCR6 | 0.673227 | 4 | 0 | 3 |
| NLRC3 | WAS | 0.67242 | 5 | 0 | 4 |
| NLRC3 | CD52 | 0.671814 | 8 | 0 | 6 |
| NLRC3 | CCR7 | 0.671813 | 5 | 0 | 5 |
| NLRC3 | CD1D | 0.670155 | 3 | 0 | 3 |
For details and further investigation, click here
