| Full name: caspase 6 | Alias Symbol: MCH2 | ||
| Type: protein-coding gene | Cytoband: 4q25 | ||
| Entrez ID: 839 | HGNC ID: HGNC:1507 | Ensembl Gene: ENSG00000138794 | OMIM ID: 601532 |
| Drug and gene relationship at DGIdb | |||
CASP6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04210 | Apoptosis |
Expression of CASP6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CASP6 | 839 | 209790_s_at | 0.7119 | 0.0929 | |
| GSE20347 | CASP6 | 839 | 211464_x_at | 0.2082 | 0.2049 | |
| GSE23400 | CASP6 | 839 | 211464_x_at | 0.0401 | 0.4210 | |
| GSE26886 | CASP6 | 839 | 211464_x_at | 0.5202 | 0.0817 | |
| GSE29001 | CASP6 | 839 | 211464_x_at | 0.3360 | 0.1030 | |
| GSE38129 | CASP6 | 839 | 211464_x_at | 0.2824 | 0.0381 | |
| GSE45670 | CASP6 | 839 | 211464_x_at | 0.1632 | 0.2960 | |
| GSE53622 | CASP6 | 839 | 115428 | 0.3832 | 0.0000 | |
| GSE53624 | CASP6 | 839 | 115428 | 0.3217 | 0.0051 | |
| GSE63941 | CASP6 | 839 | 209790_s_at | 0.3637 | 0.5403 | |
| GSE77861 | CASP6 | 839 | 211464_x_at | -0.0257 | 0.9387 | |
| GSE97050 | CASP6 | 839 | A_23_P500799 | -0.0847 | 0.7206 | |
| SRP007169 | CASP6 | 839 | RNAseq | 0.3934 | 0.3660 | |
| SRP008496 | CASP6 | 839 | RNAseq | 0.4718 | 0.1202 | |
| SRP064894 | CASP6 | 839 | RNAseq | 0.6092 | 0.0002 | |
| SRP133303 | CASP6 | 839 | RNAseq | 0.5415 | 0.0040 | |
| SRP159526 | CASP6 | 839 | RNAseq | 0.4693 | 0.0665 | |
| SRP193095 | CASP6 | 839 | RNAseq | -0.2229 | 0.2905 | |
| SRP219564 | CASP6 | 839 | RNAseq | -0.0444 | 0.8827 | |
| TCGA | CASP6 | 839 | RNAseq | -0.0076 | 0.9211 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CASP6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CASP6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CASP6 | 839 | 1 | 12 | 17 | |
| GSE20123 | CASP6 | 839 | 1 | 12 | 17 | |
| GSE43470 | CASP6 | 839 | 0 | 13 | 30 | |
| GSE46452 | CASP6 | 839 | 1 | 36 | 22 | |
| GSE47630 | CASP6 | 839 | 0 | 20 | 20 | |
| GSE54993 | CASP6 | 839 | 9 | 0 | 61 | |
| GSE54994 | CASP6 | 839 | 1 | 10 | 42 | |
| GSE60625 | CASP6 | 839 | 0 | 3 | 8 | |
| GSE74703 | CASP6 | 839 | 0 | 11 | 25 | |
| GSE74704 | CASP6 | 839 | 0 | 6 | 14 | |
| TCGA | CASP6 | 839 | 8 | 35 | 53 |
Total number of gains: 21; Total number of losses: 158; Total Number of normals: 309.
Somatic mutations of CASP6:
Generating mutation plots.
Highly correlated genes for CASP6:
Showing top 20/231 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CASP6 | ANP32A-IT1 | 0.692719 | 3 | 0 | 3 |
| CASP6 | ZNF670 | 0.688719 | 3 | 0 | 3 |
| CASP6 | HPS3 | 0.687238 | 4 | 0 | 4 |
| CASP6 | CHKA | 0.658231 | 3 | 0 | 3 |
| CASP6 | ATG2A | 0.656984 | 4 | 0 | 4 |
| CASP6 | WDR76 | 0.647815 | 4 | 0 | 3 |
| CASP6 | SLC45A3 | 0.647801 | 3 | 0 | 3 |
| CASP6 | TASP1 | 0.645865 | 4 | 0 | 4 |
| CASP6 | RPAP3 | 0.640725 | 3 | 0 | 3 |
| CASP6 | ZNF184 | 0.634186 | 4 | 0 | 3 |
| CASP6 | SELL | 0.633108 | 3 | 0 | 3 |
| CASP6 | YARS2 | 0.629638 | 4 | 0 | 3 |
| CASP6 | SNRPB2 | 0.628615 | 3 | 0 | 3 |
| CASP6 | ST7 | 0.628398 | 3 | 0 | 3 |
| CASP6 | DBT | 0.623873 | 6 | 0 | 6 |
| CASP6 | FAM161A | 0.622569 | 4 | 0 | 3 |
| CASP6 | ASB9 | 0.619143 | 5 | 0 | 4 |
| CASP6 | RYK | 0.61866 | 3 | 0 | 3 |
| CASP6 | COQ10A | 0.616854 | 4 | 0 | 3 |
| CASP6 | MTMR7 | 0.615696 | 3 | 0 | 3 |
For details and further investigation, click here
