| Full name: choline kinase alpha | Alias Symbol: CKI | ||
| Type: protein-coding gene | Cytoband: 11q13.2 | ||
| Entrez ID: 1119 | HGNC ID: HGNC:1937 | Ensembl Gene: ENSG00000110721 | OMIM ID: 118491 |
| Related drugs: DEXAMETHASONE, TCD-717... [more] | |||
Screen Evidence:
| |||
CHKA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05231 | Choline metabolism in cancer |
Expression of CHKA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHKA | 1119 | 204266_s_at | 0.3001 | 0.3986 | |
| GSE20347 | CHKA | 1119 | 204266_s_at | 0.6705 | 0.0000 | |
| GSE23400 | CHKA | 1119 | 204266_s_at | 0.0099 | 0.8806 | |
| GSE26886 | CHKA | 1119 | 204266_s_at | 0.4089 | 0.0442 | |
| GSE29001 | CHKA | 1119 | 204266_s_at | 0.6589 | 0.0031 | |
| GSE38129 | CHKA | 1119 | 204266_s_at | 0.3356 | 0.0447 | |
| GSE45670 | CHKA | 1119 | 204266_s_at | 0.0028 | 0.9893 | |
| GSE63941 | CHKA | 1119 | 204266_s_at | 0.5859 | 0.3693 | |
| GSE77861 | CHKA | 1119 | 204266_s_at | 0.0533 | 0.7554 | |
| GSE97050 | CHKA | 1119 | A_23_P124742 | -0.0205 | 0.9388 | |
| SRP007169 | CHKA | 1119 | RNAseq | 2.6879 | 0.0013 | |
| SRP008496 | CHKA | 1119 | RNAseq | 2.5154 | 0.0002 | |
| SRP064894 | CHKA | 1119 | RNAseq | 0.1669 | 0.4250 | |
| SRP133303 | CHKA | 1119 | RNAseq | 0.2506 | 0.3654 | |
| SRP159526 | CHKA | 1119 | RNAseq | 0.6723 | 0.1275 | |
| SRP193095 | CHKA | 1119 | RNAseq | 0.2544 | 0.4877 | |
| SRP219564 | CHKA | 1119 | RNAseq | 0.2883 | 0.4694 | |
| TCGA | CHKA | 1119 | RNAseq | -0.5332 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by CHKA expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CHKA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHKA | 1119 | 10 | 3 | 17 | |
| GSE20123 | CHKA | 1119 | 10 | 3 | 17 | |
| GSE43470 | CHKA | 1119 | 4 | 3 | 36 | |
| GSE46452 | CHKA | 1119 | 15 | 3 | 41 | |
| GSE47630 | CHKA | 1119 | 10 | 5 | 25 | |
| GSE54993 | CHKA | 1119 | 3 | 2 | 65 | |
| GSE54994 | CHKA | 1119 | 14 | 4 | 35 | |
| GSE60625 | CHKA | 1119 | 0 | 3 | 8 | |
| GSE74703 | CHKA | 1119 | 3 | 2 | 31 | |
| GSE74704 | CHKA | 1119 | 8 | 1 | 11 | |
| TCGA | CHKA | 1119 | 35 | 8 | 53 |
Total number of gains: 112; Total number of losses: 37; Total Number of normals: 339.
Somatic mutations of CHKA:
Generating mutation plots.
Highly correlated genes for CHKA:
Showing top 20/277 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHKA | KIFC1 | 0.744217 | 3 | 0 | 3 |
| CHKA | WDR5B | 0.708527 | 3 | 0 | 3 |
| CHKA | MFN2 | 0.673448 | 3 | 0 | 3 |
| CHKA | CCNF | 0.663158 | 3 | 0 | 3 |
| CHKA | CASP6 | 0.658231 | 3 | 0 | 3 |
| CHKA | NFKB2 | 0.655251 | 3 | 0 | 3 |
| CHKA | PGS1 | 0.655078 | 4 | 0 | 3 |
| CHKA | GUSB | 0.649549 | 3 | 0 | 3 |
| CHKA | POLR1C | 0.649514 | 3 | 0 | 3 |
| CHKA | NDE1 | 0.648133 | 3 | 0 | 3 |
| CHKA | MYNN | 0.646736 | 3 | 0 | 3 |
| CHKA | HMGB1 | 0.64378 | 3 | 0 | 3 |
| CHKA | NMNAT3 | 0.64127 | 3 | 0 | 3 |
| CHKA | GAS6-AS1 | 0.63959 | 3 | 0 | 3 |
| CHKA | SPR | 0.638229 | 4 | 0 | 4 |
| CHKA | KCNMB3 | 0.636146 | 4 | 0 | 3 |
| CHKA | MTCH1 | 0.634527 | 4 | 0 | 3 |
| CHKA | ADAM8 | 0.634008 | 3 | 0 | 3 |
| CHKA | STIL | 0.63389 | 3 | 0 | 3 |
| CHKA | SEPHS2 | 0.631022 | 3 | 0 | 3 |
For details and further investigation, click here
