| Full name: RNA polymerase II associated protein 3 | Alias Symbol: FLJ21908|spag|hSpagh|Tah1 | ||
| Type: protein-coding gene | Cytoband: 12q13.11 | ||
| Entrez ID: 79657 | HGNC ID: HGNC:26151 | Ensembl Gene: ENSG00000005175 | OMIM ID: 611477 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RPAP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPAP3 | 79657 | 218842_at | 0.3772 | 0.3413 | |
| GSE20347 | RPAP3 | 79657 | 218842_at | 0.8103 | 0.0002 | |
| GSE23400 | RPAP3 | 79657 | 218842_at | 0.6081 | 0.0000 | |
| GSE26886 | RPAP3 | 79657 | 218842_at | 0.1402 | 0.6361 | |
| GSE29001 | RPAP3 | 79657 | 218842_at | 0.5879 | 0.1921 | |
| GSE38129 | RPAP3 | 79657 | 218842_at | 0.9356 | 0.0000 | |
| GSE45670 | RPAP3 | 79657 | 218842_at | 0.5268 | 0.0001 | |
| GSE53622 | RPAP3 | 79657 | 36603 | 0.5051 | 0.0000 | |
| GSE53624 | RPAP3 | 79657 | 44473 | 0.4946 | 0.0000 | |
| GSE63941 | RPAP3 | 79657 | 218842_at | 0.4654 | 0.2219 | |
| GSE77861 | RPAP3 | 79657 | 218842_at | 0.6203 | 0.0344 | |
| GSE97050 | RPAP3 | 79657 | A_23_P2683 | 0.3059 | 0.2622 | |
| SRP007169 | RPAP3 | 79657 | RNAseq | 0.9733 | 0.0067 | |
| SRP008496 | RPAP3 | 79657 | RNAseq | 0.5768 | 0.0351 | |
| SRP064894 | RPAP3 | 79657 | RNAseq | 0.2902 | 0.0583 | |
| SRP133303 | RPAP3 | 79657 | RNAseq | 0.6917 | 0.0006 | |
| SRP159526 | RPAP3 | 79657 | RNAseq | 0.2036 | 0.3360 | |
| SRP193095 | RPAP3 | 79657 | RNAseq | 0.0925 | 0.1549 | |
| SRP219564 | RPAP3 | 79657 | RNAseq | 0.1960 | 0.4501 | |
| TCGA | RPAP3 | 79657 | RNAseq | 0.1989 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RPAP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPAP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPAP3 | 79657 | 7 | 1 | 22 | |
| GSE20123 | RPAP3 | 79657 | 7 | 1 | 22 | |
| GSE43470 | RPAP3 | 79657 | 3 | 1 | 39 | |
| GSE46452 | RPAP3 | 79657 | 8 | 1 | 50 | |
| GSE47630 | RPAP3 | 79657 | 11 | 2 | 27 | |
| GSE54993 | RPAP3 | 79657 | 0 | 5 | 65 | |
| GSE54994 | RPAP3 | 79657 | 6 | 1 | 46 | |
| GSE60625 | RPAP3 | 79657 | 0 | 0 | 11 | |
| GSE74703 | RPAP3 | 79657 | 3 | 1 | 32 | |
| GSE74704 | RPAP3 | 79657 | 4 | 1 | 15 | |
| TCGA | RPAP3 | 79657 | 16 | 12 | 68 |
Total number of gains: 65; Total number of losses: 26; Total Number of normals: 397.
Somatic mutations of RPAP3:
Generating mutation plots.
Highly correlated genes for RPAP3:
Showing top 20/1722 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPAP3 | AP1AR | 0.851133 | 3 | 0 | 3 |
| RPAP3 | RAD18 | 0.828867 | 3 | 0 | 3 |
| RPAP3 | ACBD5 | 0.77995 | 3 | 0 | 3 |
| RPAP3 | CENPBD1 | 0.754203 | 3 | 0 | 3 |
| RPAP3 | GMNN | 0.733674 | 11 | 0 | 11 |
| RPAP3 | GK5 | 0.728423 | 3 | 0 | 3 |
| RPAP3 | FARS2 | 0.724683 | 3 | 0 | 3 |
| RPAP3 | C2orf76 | 0.722656 | 3 | 0 | 3 |
| RPAP3 | EEF1E1 | 0.721603 | 9 | 0 | 8 |
| RPAP3 | RACGAP1 | 0.720129 | 10 | 0 | 10 |
| RPAP3 | NUP37 | 0.718269 | 11 | 0 | 11 |
| RPAP3 | PRDM15 | 0.716464 | 3 | 0 | 3 |
| RPAP3 | PPIL1 | 0.715117 | 7 | 0 | 7 |
| RPAP3 | SMC2 | 0.701282 | 10 | 0 | 10 |
| RPAP3 | L3MBTL3 | 0.700548 | 3 | 0 | 3 |
| RPAP3 | C1orf112 | 0.69938 | 9 | 0 | 8 |
| RPAP3 | VCPIP1 | 0.6981 | 3 | 0 | 3 |
| RPAP3 | NOL11 | 0.697795 | 11 | 0 | 9 |
| RPAP3 | FBXO33 | 0.697236 | 3 | 0 | 3 |
| RPAP3 | MAD2L1 | 0.69715 | 11 | 0 | 10 |
For details and further investigation, click here
