RYK

 

Full name: receptor like tyrosine kinase Alias Symbol: D3S3195|RYK1|JTK5
Type: protein-coding gene Cytoband: 3q22.2
Entrez ID: 6259 HGNC ID: HGNC:10481 Ensembl Gene: ENSG00000163785 OMIM ID: 600524
Drug and gene relationship at DGIdb

 

RYK involved pathways:

KEGG pathway Description View
hsa04360Axon guidance

 

Expression of RYK:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RYK 6259 202853_s_at 0.5199 0.1365
GSE20347 RYK 6259 202853_s_at 0.4217 0.0030
GSE23400 RYK 6259 202853_s_at 0.5813 0.0000
GSE26886 RYK 6259 202853_s_at 0.1247 0.5733
GSE29001 RYK 6259 202853_s_at 0.5189 0.0717
GSE38129 RYK 6259 202853_s_at 0.4208 0.0003
GSE45670 RYK 6259 202853_s_at 0.1788 0.3580
GSE63941 RYK 6259 202853_s_at -0.2339 0.6970
GSE77861 RYK 6259 202853_s_at 0.3601 0.1447
GSE97050 RYK 6259 A_33_P3379371 0.0564 0.8143
SRP007169 RYK 6259 RNAseq 0.7173 0.0268
SRP008496 RYK 6259 RNAseq 1.0796 0.0000
SRP064894 RYK 6259 RNAseq 0.1617 0.2240
SRP133303 RYK 6259 RNAseq 0.4464 0.0012
SRP159526 RYK 6259 RNAseq 0.6956 0.0116
SRP193095 RYK 6259 RNAseq 0.3206 0.0071
SRP219564 RYK 6259 RNAseq -0.1630 0.5598
TCGA RYK 6259 RNAseq 0.1492 0.0081

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by RYK expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of RYK:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RYK 6259 16 0 14
GSE20123 RYK 6259 16 0 14
GSE43470 RYK 6259 21 0 22
GSE46452 RYK 6259 15 4 40
GSE47630 RYK 6259 18 3 19
GSE54993 RYK 6259 2 8 60
GSE54994 RYK 6259 32 1 20
GSE60625 RYK 6259 0 6 5
GSE74703 RYK 6259 18 0 18
GSE74704 RYK 6259 11 0 9
TCGA RYK 6259 59 5 32

Total number of gains: 208; Total number of losses: 27; Total Number of normals: 253.  

 

Somatic mutations of RYK:

 

Generating mutation plots.

 

Highly correlated genes for RYK:

 

Showing top 20/692 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RYKMSL20.71239808
RYKHLTF0.69537610010
RYKNCBP20.69235510010
RYKDENND4A0.683093303
RYKCOX170.670537303
RYKTXLNA0.667154404
RYKCREM0.664526303
RYKHPS30.657854605
RYKHMCES0.651085707
RYKZNF518B0.648549404
RYKRMND10.647592403
RYKEID10.644615404
RYKGSK3B0.643819706
RYKATP2C10.643121009
RYKPIK3R40.6408521009
RYKGPR1580.636773303
RYKSLC5A30.635203404
RYKFLVCR10.634107404
RYKHSPB110.629815404
RYKFXR10.6294511009

For details and further investigation, click here