SNRPB2

 

Full name: small nuclear ribonucleoprotein polypeptide B2 Alias Symbol: Msl1|U2B''
Type: protein-coding gene Cytoband: 20p12.1
Entrez ID: 6629 HGNC ID: HGNC:11155 Ensembl Gene: ENSG00000125870 OMIM ID: 603520
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of SNRPB2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SNRPB2 6629 202505_at 0.6942 0.1130
GSE20347 SNRPB2 6629 202505_at 0.7105 0.0000
GSE23400 SNRPB2 6629 202505_at 0.5253 0.0000
GSE26886 SNRPB2 6629 202505_at 0.3203 0.0451
GSE29001 SNRPB2 6629 202505_at 0.5944 0.0477
GSE38129 SNRPB2 6629 202505_at 0.7130 0.0000
GSE45670 SNRPB2 6629 202505_at 0.5687 0.0011
GSE53622 SNRPB2 6629 1605 0.6800 0.0000
GSE53624 SNRPB2 6629 1605 0.8270 0.0000
GSE63941 SNRPB2 6629 202505_at -0.0346 0.9434
GSE77861 SNRPB2 6629 202505_at 0.6470 0.0031
GSE97050 SNRPB2 6629 A_23_P40307 0.3349 0.2395
SRP007169 SNRPB2 6629 RNAseq 0.0086 0.9797
SRP008496 SNRPB2 6629 RNAseq 0.1568 0.4726
SRP064894 SNRPB2 6629 RNAseq 0.7434 0.0002
SRP133303 SNRPB2 6629 RNAseq 0.6957 0.0000
SRP159526 SNRPB2 6629 RNAseq 0.5425 0.0770
SRP193095 SNRPB2 6629 RNAseq 0.1104 0.4237
SRP219564 SNRPB2 6629 RNAseq 0.3708 0.2215
TCGA SNRPB2 6629 RNAseq 0.1815 0.0030

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by SNRPB2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SNRPB2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SNRPB2 6629 11 2 17
GSE20123 SNRPB2 6629 11 1 18
GSE43470 SNRPB2 6629 11 1 31
GSE46452 SNRPB2 6629 27 1 31
GSE47630 SNRPB2 6629 17 4 19
GSE54993 SNRPB2 6629 0 15 55
GSE54994 SNRPB2 6629 26 2 25
GSE60625 SNRPB2 6629 0 0 11
GSE74703 SNRPB2 6629 8 1 27
GSE74704 SNRPB2 6629 5 1 14
TCGA SNRPB2 6629 43 10 43

Total number of gains: 159; Total number of losses: 38; Total Number of normals: 291.  

 

Somatic mutations of SNRPB2:

 

Generating mutation plots.

 

Highly correlated genes for SNRPB2:

 

Showing top 20/1787 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SNRPB2NXT10.78355412012
SNRPB2TP53RK0.782446303
SNRPB2CDC25B0.75951510010
SNRPB2PCNA0.75666212012
SNRPB2TRMT60.74979808
SNRPB2KHDC10.746772303
SNRPB2DCLRE1B0.736324303
SNRPB2PFDN40.73455611011
SNRPB2ZNF7070.729677303
SNRPB2SCNM10.728843303
SNRPB2HSPD10.72858610010
SNRPB2GINS10.72367411011
SNRPB2MRPS50.719027303
SNRPB2ELOF10.718498303
SNRPB2FADS10.714703303
SNRPB2C20orf270.71239810010
SNRPB2ZIC50.711448303
SNRPB2PFDN20.71137111011
SNRPB2AP1AR0.711276303
SNRPB2YTHDF10.7100151009

For details and further investigation, click here