YARS2

 

Full name: tyrosyl-tRNA synthetase 2 Alias Symbol: FLJ13995|CGI-04|mt-TyrRS
Type: protein-coding gene Cytoband: 12p11.21
Entrez ID: 51067 HGNC ID: HGNC:24249 Ensembl Gene: ENSG00000139131 OMIM ID: 610957
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of YARS2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 YARS2 51067 218470_at 0.5171 0.0548
GSE20347 YARS2 51067 218470_at 0.4869 0.0153
GSE23400 YARS2 51067 218470_at 0.4479 0.0000
GSE26886 YARS2 51067 218470_at 0.9902 0.0010
GSE29001 YARS2 51067 218470_at 0.4743 0.1241
GSE38129 YARS2 51067 218470_at 0.6444 0.0007
GSE45670 YARS2 51067 218470_at 0.6057 0.0001
GSE53622 YARS2 51067 156643 0.7021 0.0000
GSE53624 YARS2 51067 156643 0.6942 0.0000
GSE63941 YARS2 51067 218470_at 0.5196 0.2778
GSE77861 YARS2 51067 218470_at 0.2029 0.2547
GSE97050 YARS2 51067 A_23_P151093 0.4815 0.1623
SRP007169 YARS2 51067 RNAseq 0.5862 0.0921
SRP008496 YARS2 51067 RNAseq 0.1847 0.4873
SRP064894 YARS2 51067 RNAseq 0.3279 0.0501
SRP133303 YARS2 51067 RNAseq 0.5823 0.0029
SRP159526 YARS2 51067 RNAseq 0.3786 0.1371
SRP193095 YARS2 51067 RNAseq 0.1639 0.1693
SRP219564 YARS2 51067 RNAseq 0.1184 0.7123
TCGA YARS2 51067 RNAseq 0.2903 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by YARS2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of YARS2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 YARS2 51067 10 3 17
GSE20123 YARS2 51067 10 3 17
GSE43470 YARS2 51067 7 4 32
GSE46452 YARS2 51067 10 1 48
GSE47630 YARS2 51067 12 1 27
GSE54993 YARS2 51067 0 9 61
GSE54994 YARS2 51067 8 2 43
GSE60625 YARS2 51067 0 1 10
GSE74703 YARS2 51067 7 3 26
GSE74704 YARS2 51067 6 1 13
TCGA YARS2 51067 39 5 52

Total number of gains: 109; Total number of losses: 33; Total Number of normals: 346.  

 

Somatic mutations of YARS2:

 

Generating mutation plots.

 

Highly correlated genes for YARS2:

 

Showing top 20/1904 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
YARS2SPNS10.849755303
YARS2CHAMP10.779785303
YARS2PRELID10.769723303
YARS2PPP1R9B0.763332303
YARS2NOP20.75803412012
YARS2CENPBD10.752571303
YARS2ANAPC10.74972303
YARS2MMS22L0.745534303
YARS2PSMG30.727553606
YARS2USP420.727161505
YARS2MAZ0.726292707
YARS2SLC35B20.723475303
YARS2CNOT100.72072303
YARS2ZC3HC10.717724504
YARS2MRPL510.716658908
YARS2NOP560.716553303
YARS2PYCR20.715201303
YARS2COL17A10.713494303
YARS2RAD180.711782403
YARS2EME10.711242505

For details and further investigation, click here