| Full name: Cas scaffold protein family member 4 | Alias Symbol: HEFL|HEPL | ||
| Type: protein-coding gene | Cytoband: 20q13.31 | ||
| Entrez ID: 57091 | HGNC ID: HGNC:15878 | Ensembl Gene: ENSG00000087589 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of CASS4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CASS4 | 57091 | 220888_s_at | -0.0751 | 0.7079 | |
| GSE20347 | CASS4 | 57091 | 220888_s_at | -0.0706 | 0.2428 | |
| GSE23400 | CASS4 | 57091 | 220888_s_at | -0.1578 | 0.0000 | |
| GSE26886 | CASS4 | 57091 | 220888_s_at | 0.1058 | 0.3731 | |
| GSE29001 | CASS4 | 57091 | 220888_s_at | -0.1246 | 0.2099 | |
| GSE38129 | CASS4 | 57091 | 220888_s_at | -0.0668 | 0.2318 | |
| GSE45670 | CASS4 | 57091 | 220888_s_at | -0.1296 | 0.1690 | |
| GSE53622 | CASS4 | 57091 | 144763 | 0.1903 | 0.0169 | |
| GSE53624 | CASS4 | 57091 | 144763 | -0.1427 | 0.1186 | |
| GSE63941 | CASS4 | 57091 | 220888_s_at | 0.1341 | 0.3312 | |
| GSE77861 | CASS4 | 57091 | 220888_s_at | -0.0718 | 0.3999 | |
| GSE97050 | CASS4 | 57091 | A_33_P3228931 | 0.1953 | 0.3684 | |
| SRP007169 | CASS4 | 57091 | RNAseq | 0.7620 | 0.3082 | |
| SRP064894 | CASS4 | 57091 | RNAseq | 0.5125 | 0.0381 | |
| SRP133303 | CASS4 | 57091 | RNAseq | 0.1586 | 0.2533 | |
| SRP159526 | CASS4 | 57091 | RNAseq | 0.2038 | 0.7398 | |
| SRP193095 | CASS4 | 57091 | RNAseq | 0.7442 | 0.0001 | |
| SRP219564 | CASS4 | 57091 | RNAseq | 0.4322 | 0.3735 | |
| TCGA | CASS4 | 57091 | RNAseq | 0.0735 | 0.7835 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CASS4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CASS4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CASS4 | 57091 | 14 | 2 | 14 | |
| GSE20123 | CASS4 | 57091 | 14 | 2 | 14 | |
| GSE43470 | CASS4 | 57091 | 13 | 0 | 30 | |
| GSE46452 | CASS4 | 57091 | 29 | 0 | 30 | |
| GSE47630 | CASS4 | 57091 | 24 | 1 | 15 | |
| GSE54993 | CASS4 | 57091 | 0 | 17 | 53 | |
| GSE54994 | CASS4 | 57091 | 27 | 0 | 26 | |
| GSE60625 | CASS4 | 57091 | 0 | 0 | 11 | |
| GSE74703 | CASS4 | 57091 | 11 | 0 | 25 | |
| GSE74704 | CASS4 | 57091 | 11 | 0 | 9 | |
| TCGA | CASS4 | 57091 | 43 | 4 | 49 |
Total number of gains: 186; Total number of losses: 26; Total Number of normals: 276.
Somatic mutations of CASS4:
Generating mutation plots.
Highly correlated genes for CASS4:
Showing top 20/543 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CASS4 | FES | 0.799058 | 3 | 0 | 3 |
| CASS4 | STRC | 0.740391 | 3 | 0 | 3 |
| CASS4 | DCDC1 | 0.721913 | 3 | 0 | 3 |
| CASS4 | NUTM1 | 0.716254 | 3 | 0 | 3 |
| CASS4 | OR4D6 | 0.711144 | 3 | 0 | 3 |
| CASS4 | SUN5 | 0.700758 | 4 | 0 | 4 |
| CASS4 | LCE1D | 0.696062 | 3 | 0 | 3 |
| CASS4 | PLA2G2C | 0.680469 | 3 | 0 | 3 |
| CASS4 | NKX6-3 | 0.678356 | 3 | 0 | 3 |
| CASS4 | FBRSL1 | 0.670481 | 3 | 0 | 3 |
| CASS4 | DEFB128 | 0.669247 | 3 | 0 | 3 |
| CASS4 | FSIP1 | 0.667012 | 3 | 0 | 3 |
| CASS4 | MIATNB | 0.666559 | 3 | 0 | 3 |
| CASS4 | ABCG8 | 0.665562 | 3 | 0 | 3 |
| CASS4 | SCAMP5 | 0.664551 | 3 | 0 | 3 |
| CASS4 | HAPLN4 | 0.664242 | 4 | 0 | 3 |
| CASS4 | SLC22A31 | 0.659742 | 4 | 0 | 4 |
| CASS4 | CCR3 | 0.659619 | 6 | 0 | 6 |
| CASS4 | SLC39A5 | 0.657898 | 4 | 0 | 3 |
| CASS4 | C1QL2 | 0.657595 | 3 | 0 | 3 |
For details and further investigation, click here
