| Full name: C-C motif chemokine receptor 3 | Alias Symbol: CC-CKR-3|CKR3|CD193 | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 1232 | HGNC ID: HGNC:1604 | Ensembl Gene: ENSG00000183625 | OMIM ID: 601268 |
| Drug and gene relationship at DGIdb | |||
CCR3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of CCR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCR3 | 1232 | 208304_at | -0.0323 | 0.9219 | |
| GSE20347 | CCR3 | 1232 | 208304_at | 0.0422 | 0.6706 | |
| GSE23400 | CCR3 | 1232 | 208304_at | -0.0510 | 0.3248 | |
| GSE26886 | CCR3 | 1232 | 208304_at | 0.1911 | 0.1656 | |
| GSE29001 | CCR3 | 1232 | 208304_at | 0.0554 | 0.7190 | |
| GSE38129 | CCR3 | 1232 | 208304_at | -0.0160 | 0.8822 | |
| GSE45670 | CCR3 | 1232 | 208304_at | 0.0342 | 0.7428 | |
| GSE53622 | CCR3 | 1232 | 68846 | 0.2223 | 0.2599 | |
| GSE53624 | CCR3 | 1232 | 45493 | 0.3457 | 0.1513 | |
| GSE63941 | CCR3 | 1232 | 208304_at | 0.2478 | 0.3029 | |
| GSE77861 | CCR3 | 1232 | 208304_at | -0.0282 | 0.7500 | |
| GSE97050 | CCR3 | 1232 | A_23_P250302 | 0.1606 | 0.4780 | |
| TCGA | CCR3 | 1232 | RNAseq | 0.1051 | 0.8616 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CCR3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCR3 | 1232 | 0 | 17 | 13 | |
| GSE20123 | CCR3 | 1232 | 0 | 18 | 12 | |
| GSE43470 | CCR3 | 1232 | 0 | 20 | 23 | |
| GSE46452 | CCR3 | 1232 | 2 | 17 | 40 | |
| GSE47630 | CCR3 | 1232 | 2 | 23 | 15 | |
| GSE54993 | CCR3 | 1232 | 7 | 2 | 61 | |
| GSE54994 | CCR3 | 1232 | 0 | 36 | 17 | |
| GSE60625 | CCR3 | 1232 | 5 | 0 | 6 | |
| GSE74703 | CCR3 | 1232 | 0 | 15 | 21 | |
| GSE74704 | CCR3 | 1232 | 0 | 12 | 8 | |
| TCGA | CCR3 | 1232 | 1 | 75 | 20 |
Total number of gains: 17; Total number of losses: 235; Total Number of normals: 236.
Somatic mutations of CCR3:
Generating mutation plots.
Highly correlated genes for CCR3:
Showing top 20/589 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCR3 | CHRM2 | 0.704406 | 4 | 0 | 4 |
| CCR3 | CCZ1 | 0.697174 | 4 | 0 | 4 |
| CCR3 | IFNA17 | 0.682122 | 4 | 0 | 4 |
| CCR3 | NTNG1 | 0.679414 | 4 | 0 | 4 |
| CCR3 | FOLH1 | 0.678308 | 5 | 0 | 5 |
| CCR3 | ALPL | 0.673618 | 4 | 0 | 3 |
| CCR3 | TACR3 | 0.667908 | 4 | 0 | 4 |
| CCR3 | KRT76 | 0.666557 | 4 | 0 | 4 |
| CCR3 | ULK4 | 0.666383 | 3 | 0 | 3 |
| CCR3 | SELL | 0.665798 | 3 | 0 | 3 |
| CCR3 | SIRPD | 0.664651 | 4 | 0 | 3 |
| CCR3 | ASPHD1 | 0.664495 | 3 | 0 | 3 |
| CCR3 | KRT38 | 0.663532 | 5 | 0 | 4 |
| CCR3 | IFNA4 | 0.661537 | 6 | 0 | 5 |
| CCR3 | CASS4 | 0.659619 | 6 | 0 | 6 |
| CCR3 | FTCD | 0.658927 | 4 | 0 | 4 |
| CCR3 | NPY2R | 0.654873 | 4 | 0 | 4 |
| CCR3 | MYRFL | 0.654673 | 4 | 0 | 4 |
| CCR3 | LCT | 0.653207 | 5 | 0 | 5 |
| CCR3 | S100G | 0.653013 | 5 | 0 | 5 |
For details and further investigation, click here
