| Full name: ATP binding cassette subfamily G member 8 | Alias Symbol: GBD4 | ||
| Type: protein-coding gene | Cytoband: 2p21 | ||
| Entrez ID: 64241 | HGNC ID: HGNC:13887 | Ensembl Gene: ENSG00000143921 | OMIM ID: 605460 |
| Drug and gene relationship at DGIdb | |||
Expression of ABCG8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABCG8 | 64241 | 231751_at | -0.0500 | 0.8267 | |
| GSE26886 | ABCG8 | 64241 | 231751_at | 0.1511 | 0.0878 | |
| GSE45670 | ABCG8 | 64241 | 231751_at | 0.0093 | 0.9311 | |
| GSE53622 | ABCG8 | 64241 | 84560 | 0.3920 | 0.0000 | |
| GSE53624 | ABCG8 | 64241 | 84560 | 0.4044 | 0.0451 | |
| GSE63941 | ABCG8 | 64241 | 231751_at | -0.0481 | 0.8059 | |
| GSE77861 | ABCG8 | 64241 | 231751_at | 0.0642 | 0.5572 | |
| GSE97050 | ABCG8 | 64241 | A_33_P3361112 | 0.1145 | 0.6597 | |
| SRP007169 | ABCG8 | 64241 | RNAseq | 1.9581 | 0.0362 | |
| SRP133303 | ABCG8 | 64241 | RNAseq | 0.0959 | 0.4480 | |
| SRP159526 | ABCG8 | 64241 | RNAseq | 0.5315 | 0.1960 | |
| SRP193095 | ABCG8 | 64241 | RNAseq | -0.1589 | 0.3627 | |
| SRP219564 | ABCG8 | 64241 | RNAseq | -0.1159 | 0.7975 | |
| TCGA | ABCG8 | 64241 | RNAseq | -0.0557 | 0.9502 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ABCG8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABCG8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABCG8 | 64241 | 10 | 1 | 19 | |
| GSE20123 | ABCG8 | 64241 | 9 | 1 | 20 | |
| GSE43470 | ABCG8 | 64241 | 4 | 0 | 39 | |
| GSE46452 | ABCG8 | 64241 | 1 | 4 | 54 | |
| GSE47630 | ABCG8 | 64241 | 7 | 0 | 33 | |
| GSE54993 | ABCG8 | 64241 | 0 | 5 | 65 | |
| GSE54994 | ABCG8 | 64241 | 10 | 0 | 43 | |
| GSE60625 | ABCG8 | 64241 | 0 | 3 | 8 | |
| GSE74703 | ABCG8 | 64241 | 4 | 0 | 32 | |
| GSE74704 | ABCG8 | 64241 | 9 | 1 | 10 | |
| TCGA | ABCG8 | 64241 | 35 | 2 | 59 |
Total number of gains: 89; Total number of losses: 17; Total Number of normals: 382.
Somatic mutations of ABCG8:
Generating mutation plots.
Highly correlated genes for ABCG8:
Showing top 20/48 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABCG8 | CELF5 | 0.714926 | 3 | 0 | 3 |
| ABCG8 | NTNG2 | 0.707466 | 3 | 0 | 3 |
| ABCG8 | C20orf85 | 0.700432 | 3 | 0 | 3 |
| ABCG8 | SPTBN4 | 0.695408 | 3 | 0 | 3 |
| ABCG8 | STX1B | 0.690416 | 4 | 0 | 3 |
| ABCG8 | TP73 | 0.685076 | 3 | 0 | 3 |
| ABCG8 | PRDM13 | 0.681674 | 3 | 0 | 3 |
| ABCG8 | OR2C1 | 0.675443 | 3 | 0 | 3 |
| ABCG8 | CNGB3 | 0.665712 | 3 | 0 | 3 |
| ABCG8 | CASS4 | 0.665562 | 3 | 0 | 3 |
| ABCG8 | KIFC2 | 0.663003 | 4 | 0 | 3 |
| ABCG8 | FOXE3 | 0.661346 | 4 | 0 | 3 |
| ABCG8 | ZNF569 | 0.66113 | 3 | 0 | 3 |
| ABCG8 | ADRA1B | 0.654165 | 3 | 0 | 3 |
| ABCG8 | DRD3 | 0.64872 | 5 | 0 | 3 |
| ABCG8 | PKLR | 0.648497 | 3 | 0 | 3 |
| ABCG8 | BMP8B | 0.6306 | 4 | 0 | 3 |
| ABCG8 | DYNC1LI1 | 0.630091 | 3 | 0 | 3 |
| ABCG8 | EDA | 0.624346 | 4 | 0 | 3 |
| ABCG8 | PGP | 0.620327 | 4 | 0 | 3 |
For details and further investigation, click here
