| Full name: cholecystokinin B receptor | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11p15.4 | ||
| Entrez ID: 887 | HGNC ID: HGNC:1571 | Ensembl Gene: ENSG00000110148 | OMIM ID: 118445 |
| Drug and gene relationship at DGIdb | |||
CCKBR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04971 | Gastric acid secretion |
Expression of CCKBR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCKBR | 887 | 210381_s_at | -0.1147 | 0.7000 | |
| GSE20347 | CCKBR | 887 | 210381_s_at | -0.0035 | 0.9785 | |
| GSE23400 | CCKBR | 887 | 210381_s_at | -0.2143 | 0.0000 | |
| GSE26886 | CCKBR | 887 | 210381_s_at | 0.0156 | 0.9537 | |
| GSE29001 | CCKBR | 887 | 210381_s_at | -0.3506 | 0.0029 | |
| GSE38129 | CCKBR | 887 | 210381_s_at | -0.1950 | 0.2117 | |
| GSE45670 | CCKBR | 887 | 210381_s_at | -0.1718 | 0.1131 | |
| GSE53622 | CCKBR | 887 | 22141 | 0.5901 | 0.0000 | |
| GSE53624 | CCKBR | 887 | 22141 | 0.4410 | 0.0000 | |
| GSE63941 | CCKBR | 887 | 210381_s_at | -0.2602 | 0.2151 | |
| GSE77861 | CCKBR | 887 | 210381_s_at | -0.2803 | 0.0407 | |
| GSE97050 | CCKBR | 887 | A_23_P162010 | -0.0090 | 0.9748 | |
| TCGA | CCKBR | 887 | RNAseq | -4.7943 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CCKBR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCKBR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCKBR | 887 | 1 | 11 | 18 | |
| GSE20123 | CCKBR | 887 | 1 | 11 | 18 | |
| GSE43470 | CCKBR | 887 | 1 | 8 | 34 | |
| GSE46452 | CCKBR | 887 | 7 | 8 | 44 | |
| GSE47630 | CCKBR | 887 | 2 | 12 | 26 | |
| GSE54993 | CCKBR | 887 | 3 | 1 | 66 | |
| GSE54994 | CCKBR | 887 | 2 | 12 | 39 | |
| GSE60625 | CCKBR | 887 | 0 | 0 | 11 | |
| GSE74703 | CCKBR | 887 | 1 | 6 | 29 | |
| GSE74704 | CCKBR | 887 | 0 | 8 | 12 | |
| TCGA | CCKBR | 887 | 9 | 39 | 48 |
Total number of gains: 27; Total number of losses: 116; Total Number of normals: 345.
Somatic mutations of CCKBR:
Generating mutation plots.
Highly correlated genes for CCKBR:
Showing top 20/410 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCKBR | ZNF341 | 0.738447 | 3 | 0 | 3 |
| CCKBR | SEC14L3 | 0.710031 | 4 | 0 | 4 |
| CCKBR | PSG4 | 0.701259 | 3 | 0 | 3 |
| CCKBR | STX1B | 0.68995 | 3 | 0 | 3 |
| CCKBR | MAATS1 | 0.684162 | 3 | 0 | 3 |
| CCKBR | G6PC | 0.676297 | 3 | 0 | 3 |
| CCKBR | FNDC9 | 0.66511 | 3 | 0 | 3 |
| CCKBR | NEUROD1 | 0.665077 | 4 | 0 | 4 |
| CCKBR | GALR3 | 0.663556 | 5 | 0 | 5 |
| CCKBR | SYPL2 | 0.662997 | 4 | 0 | 3 |
| CCKBR | SPRED3 | 0.659515 | 3 | 0 | 3 |
| CCKBR | IL1RAPL1 | 0.656408 | 4 | 0 | 4 |
| CCKBR | LENG9 | 0.656191 | 3 | 0 | 3 |
| CCKBR | SSTR4 | 0.655472 | 3 | 0 | 3 |
| CCKBR | GSN-AS1 | 0.654549 | 4 | 0 | 3 |
| CCKBR | MEGF11 | 0.653869 | 3 | 0 | 3 |
| CCKBR | GRM4 | 0.652854 | 4 | 0 | 3 |
| CCKBR | POMT2 | 0.649818 | 3 | 0 | 3 |
| CCKBR | ZNF835 | 0.647478 | 5 | 0 | 5 |
| CCKBR | DMGDH | 0.647169 | 3 | 0 | 3 |
For details and further investigation, click here
