| Full name: glutamate metabotropic receptor 4 | Alias Symbol: GPRC1D|mGlu4|MGLUR4 | ||
| Type: protein-coding gene | Cytoband: 6p21.31 | ||
| Entrez ID: 2914 | HGNC ID: HGNC:4596 | Ensembl Gene: ENSG00000124493 | OMIM ID: 604100 |
| Drug and gene relationship at DGIdb | |||
GRM4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04072 | Phospholipase D signaling pathway | |
| hsa04724 | Glutamatergic synapse | |
| hsa04742 | Taste transduction |
Expression of GRM4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRM4 | 2914 | 210234_at | 0.0626 | 0.8572 | |
| GSE20347 | GRM4 | 2914 | 210234_at | -0.0765 | 0.2435 | |
| GSE23400 | GRM4 | 2914 | 210234_at | -0.1958 | 0.0001 | |
| GSE26886 | GRM4 | 2914 | 210234_at | 0.1138 | 0.3890 | |
| GSE29001 | GRM4 | 2914 | 210234_at | -0.1141 | 0.4041 | |
| GSE38129 | GRM4 | 2914 | 210234_at | -0.0876 | 0.3678 | |
| GSE45670 | GRM4 | 2914 | 210234_at | -0.0240 | 0.8541 | |
| GSE53622 | GRM4 | 2914 | 32135 | 0.0273 | 0.7779 | |
| GSE53624 | GRM4 | 2914 | 32135 | 0.4231 | 0.0002 | |
| GSE63941 | GRM4 | 2914 | 210234_at | 0.2530 | 0.0902 | |
| GSE77861 | GRM4 | 2914 | 210234_at | -0.0794 | 0.5036 | |
| GSE97050 | GRM4 | 2914 | A_33_P3282390 | 0.0555 | 0.8826 | |
| SRP133303 | GRM4 | 2914 | RNAseq | 0.2909 | 0.2673 | |
| TCGA | GRM4 | 2914 | RNAseq | 2.5385 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GRM4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRM4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRM4 | 2914 | 5 | 0 | 25 | |
| GSE20123 | GRM4 | 2914 | 5 | 0 | 25 | |
| GSE43470 | GRM4 | 2914 | 6 | 1 | 36 | |
| GSE46452 | GRM4 | 2914 | 2 | 9 | 48 | |
| GSE47630 | GRM4 | 2914 | 8 | 4 | 28 | |
| GSE54993 | GRM4 | 2914 | 3 | 1 | 66 | |
| GSE54994 | GRM4 | 2914 | 11 | 4 | 38 | |
| GSE60625 | GRM4 | 2914 | 1 | 0 | 10 | |
| GSE74703 | GRM4 | 2914 | 5 | 0 | 31 | |
| GSE74704 | GRM4 | 2914 | 2 | 0 | 18 | |
| TCGA | GRM4 | 2914 | 16 | 15 | 65 |
Total number of gains: 64; Total number of losses: 34; Total Number of normals: 390.
Somatic mutations of GRM4:
Generating mutation plots.
Highly correlated genes for GRM4:
Showing top 20/931 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRM4 | OR2T27 | 0.754927 | 3 | 0 | 3 |
| GRM4 | C14orf180 | 0.754208 | 3 | 0 | 3 |
| GRM4 | OR5A1 | 0.752762 | 3 | 0 | 3 |
| GRM4 | C10orf91 | 0.737757 | 3 | 0 | 3 |
| GRM4 | MEGF10 | 0.729695 | 3 | 0 | 3 |
| GRM4 | ERN1 | 0.723975 | 4 | 0 | 4 |
| GRM4 | GZMH | 0.723906 | 3 | 0 | 3 |
| GRM4 | PIGQ | 0.719769 | 3 | 0 | 3 |
| GRM4 | HRC | 0.710844 | 4 | 0 | 4 |
| GRM4 | SYT3 | 0.691481 | 3 | 0 | 3 |
| GRM4 | SPACA3 | 0.691473 | 4 | 0 | 3 |
| GRM4 | DEFB108B | 0.685498 | 3 | 0 | 3 |
| GRM4 | OR2C1 | 0.681871 | 6 | 0 | 6 |
| GRM4 | RAI1 | 0.681854 | 5 | 0 | 5 |
| GRM4 | TNXB | 0.67776 | 5 | 0 | 5 |
| GRM4 | CPA2 | 0.668495 | 3 | 0 | 3 |
| GRM4 | ACBD4 | 0.667936 | 5 | 0 | 5 |
| GRM4 | RHBG | 0.667522 | 6 | 0 | 5 |
| GRM4 | CLDN14 | 0.665548 | 4 | 0 | 4 |
| GRM4 | RGSL1 | 0.66451 | 4 | 0 | 4 |
For details and further investigation, click here
