| Full name: glucose-6-phosphatase catalytic subunit | Alias Symbol: GSD1a|G6PC1 | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 2538 | HGNC ID: HGNC:4056 | Ensembl Gene: ENSG00000131482 | OMIM ID: 613742 |
| Drug and gene relationship at DGIdb | |||
G6PC involved pathways:
Expression of G6PC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | G6PC | 2538 | 1555612_s_at | -0.1628 | 0.4618 | |
| GSE20347 | G6PC | 2538 | 206952_at | -0.1577 | 0.0018 | |
| GSE23400 | G6PC | 2538 | 206952_at | -0.0770 | 0.0000 | |
| GSE26886 | G6PC | 2538 | 1555612_s_at | -0.1942 | 0.1231 | |
| GSE29001 | G6PC | 2538 | 206952_at | -0.1517 | 0.1829 | |
| GSE38129 | G6PC | 2538 | 206952_at | -0.1304 | 0.0029 | |
| GSE45670 | G6PC | 2538 | 1555612_s_at | 0.1375 | 0.1498 | |
| GSE53622 | G6PC | 2538 | 136225 | -0.2066 | 0.0558 | |
| GSE53624 | G6PC | 2538 | 136225 | -0.0728 | 0.3348 | |
| GSE63941 | G6PC | 2538 | 1555612_s_at | 0.2488 | 0.1558 | |
| GSE77861 | G6PC | 2538 | 1555612_s_at | -0.3868 | 0.0011 | |
| SRP133303 | G6PC | 2538 | RNAseq | 0.1297 | 0.2861 | |
| SRP193095 | G6PC | 2538 | RNAseq | 0.0139 | 0.9188 | |
| SRP219564 | G6PC | 2538 | RNAseq | 0.5662 | 0.2650 | |
| TCGA | G6PC | 2538 | RNAseq | -2.4650 | 0.0585 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by G6PC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of G6PC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | G6PC | 2538 | 6 | 2 | 22 | |
| GSE20123 | G6PC | 2538 | 6 | 2 | 22 | |
| GSE43470 | G6PC | 2538 | 1 | 2 | 40 | |
| GSE46452 | G6PC | 2538 | 34 | 0 | 25 | |
| GSE47630 | G6PC | 2538 | 8 | 1 | 31 | |
| GSE54993 | G6PC | 2538 | 3 | 4 | 63 | |
| GSE54994 | G6PC | 2538 | 8 | 5 | 40 | |
| GSE60625 | G6PC | 2538 | 4 | 0 | 7 | |
| GSE74703 | G6PC | 2538 | 1 | 1 | 34 | |
| GSE74704 | G6PC | 2538 | 4 | 1 | 15 | |
| TCGA | G6PC | 2538 | 22 | 7 | 67 |
Total number of gains: 97; Total number of losses: 25; Total Number of normals: 366.
Somatic mutations of G6PC:
Generating mutation plots.
Highly correlated genes for G6PC:
Showing top 20/602 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| G6PC | SSTR4 | 0.734429 | 3 | 0 | 3 |
| G6PC | THRB | 0.688955 | 3 | 0 | 3 |
| G6PC | SEZ6L | 0.686346 | 3 | 0 | 3 |
| G6PC | SLC7A14 | 0.684553 | 3 | 0 | 3 |
| G6PC | TIAF1 | 0.678663 | 4 | 0 | 3 |
| G6PC | MC5R | 0.678306 | 3 | 0 | 3 |
| G6PC | CCKBR | 0.676297 | 3 | 0 | 3 |
| G6PC | FLI1 | 0.673616 | 3 | 0 | 3 |
| G6PC | C17orf64 | 0.672292 | 3 | 0 | 3 |
| G6PC | MUC5AC | 0.66935 | 3 | 0 | 3 |
| G6PC | PAX8 | 0.668435 | 4 | 0 | 4 |
| G6PC | LINC00557 | 0.66793 | 3 | 0 | 3 |
| G6PC | FAM209B | 0.665161 | 3 | 0 | 3 |
| G6PC | DPF3 | 0.663028 | 3 | 0 | 3 |
| G6PC | CD5L | 0.661276 | 4 | 0 | 4 |
| G6PC | CCL24 | 0.661236 | 3 | 0 | 3 |
| G6PC | DOCK9 | 0.660431 | 5 | 0 | 4 |
| G6PC | CRHR2 | 0.657199 | 4 | 0 | 3 |
| G6PC | RAB27B | 0.656561 | 4 | 0 | 4 |
| G6PC | ELSPBP1 | 0.656204 | 4 | 0 | 3 |
For details and further investigation, click here
