| Full name: C-C motif chemokine receptor 7 | Alias Symbol: BLR2|CDw197|CD197 | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 1236 | HGNC ID: HGNC:1608 | Ensembl Gene: ENSG00000126353 | OMIM ID: 600242 |
| Drug and gene relationship at DGIdb | |||
CCR7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of CCR7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCR7 | 1236 | 206337_at | 0.6078 | 0.7579 | |
| GSE20347 | CCR7 | 1236 | 206337_at | 0.2409 | 0.4024 | |
| GSE23400 | CCR7 | 1236 | 206337_at | -0.0568 | 0.5016 | |
| GSE26886 | CCR7 | 1236 | 206337_at | -0.0428 | 0.8979 | |
| GSE29001 | CCR7 | 1236 | 206337_at | 0.1566 | 0.4091 | |
| GSE38129 | CCR7 | 1236 | 206337_at | 0.0388 | 0.9069 | |
| GSE45670 | CCR7 | 1236 | 206337_at | 0.1875 | 0.5817 | |
| GSE53622 | CCR7 | 1236 | 55351 | -0.4176 | 0.0433 | |
| GSE53624 | CCR7 | 1236 | 55351 | -0.9386 | 0.0000 | |
| GSE63941 | CCR7 | 1236 | 206337_at | 0.2828 | 0.0517 | |
| GSE77861 | CCR7 | 1236 | 206337_at | 0.0387 | 0.7419 | |
| GSE97050 | CCR7 | 1236 | A_23_P343398 | 1.4499 | 0.1449 | |
| SRP064894 | CCR7 | 1236 | RNAseq | 0.4145 | 0.2219 | |
| SRP133303 | CCR7 | 1236 | RNAseq | -0.4163 | 0.2443 | |
| SRP159526 | CCR7 | 1236 | RNAseq | -0.7843 | 0.3551 | |
| SRP193095 | CCR7 | 1236 | RNAseq | 0.9137 | 0.0185 | |
| SRP219564 | CCR7 | 1236 | RNAseq | -0.0489 | 0.9464 | |
| TCGA | CCR7 | 1236 | RNAseq | -0.1661 | 0.5710 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CCR7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCR7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCR7 | 1236 | 7 | 1 | 22 | |
| GSE20123 | CCR7 | 1236 | 7 | 1 | 22 | |
| GSE43470 | CCR7 | 1236 | 1 | 2 | 40 | |
| GSE46452 | CCR7 | 1236 | 34 | 0 | 25 | |
| GSE47630 | CCR7 | 1236 | 8 | 1 | 31 | |
| GSE54993 | CCR7 | 1236 | 3 | 4 | 63 | |
| GSE54994 | CCR7 | 1236 | 8 | 5 | 40 | |
| GSE60625 | CCR7 | 1236 | 4 | 0 | 7 | |
| GSE74703 | CCR7 | 1236 | 1 | 1 | 34 | |
| GSE74704 | CCR7 | 1236 | 5 | 1 | 14 | |
| TCGA | CCR7 | 1236 | 23 | 8 | 65 |
Total number of gains: 101; Total number of losses: 24; Total Number of normals: 363.
Somatic mutations of CCR7:
Generating mutation plots.
Highly correlated genes for CCR7:
Showing top 20/322 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCR7 | GPR174 | 0.78063 | 3 | 0 | 3 |
| CCR7 | CD28 | 0.769289 | 4 | 0 | 4 |
| CCR7 | RUNX2 | 0.766848 | 3 | 0 | 3 |
| CCR7 | SELL | 0.731347 | 10 | 0 | 8 |
| CCR7 | P2RY8 | 0.728286 | 5 | 0 | 4 |
| CCR7 | SASH3 | 0.719244 | 12 | 0 | 10 |
| CCR7 | JAK3 | 0.715643 | 6 | 0 | 6 |
| CCR7 | SLAMF6 | 0.712446 | 6 | 0 | 6 |
| CCR7 | LINC01215 | 0.706582 | 6 | 0 | 5 |
| CCR7 | LTB | 0.697488 | 11 | 0 | 10 |
| CCR7 | MS4A1 | 0.695127 | 10 | 0 | 9 |
| CCR7 | ZAP70 | 0.687928 | 10 | 0 | 8 |
| CCR7 | CLEC17A | 0.68789 | 3 | 0 | 3 |
| CCR7 | CYTIP | 0.68399 | 10 | 0 | 8 |
| CCR7 | CSF2RB | 0.680927 | 9 | 0 | 9 |
| CCR7 | FCRL3 | 0.678476 | 7 | 0 | 6 |
| CCR7 | ITGAL | 0.674057 | 11 | 0 | 10 |
| CCR7 | ITK | 0.674044 | 11 | 0 | 8 |
| CCR7 | CORO1A | 0.673631 | 13 | 0 | 11 |
| CCR7 | CD79A | 0.673619 | 11 | 0 | 9 |
For details and further investigation, click here
