| Full name: RUNX family transcription factor 2 | Alias Symbol: AML3|PEBP2A1|PEBP2aA1 | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 860 | HGNC ID: HGNC:10472 | Ensembl Gene: ENSG00000124813 | OMIM ID: 600211 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RUNX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RUNX2 | 860 | 232231_at | 0.4932 | 0.6338 | |
| GSE20347 | RUNX2 | 860 | 221282_x_at | 0.0605 | 0.3981 | |
| GSE23400 | RUNX2 | 860 | 221282_x_at | -0.0944 | 0.0174 | |
| GSE26886 | RUNX2 | 860 | 232231_at | 2.9374 | 0.0001 | |
| GSE29001 | RUNX2 | 860 | 221282_x_at | -0.0684 | 0.6845 | |
| GSE38129 | RUNX2 | 860 | 221282_x_at | -0.0707 | 0.4115 | |
| GSE45670 | RUNX2 | 860 | 232231_at | 1.3383 | 0.0038 | |
| GSE53622 | RUNX2 | 860 | 26537 | 1.9316 | 0.0000 | |
| GSE53624 | RUNX2 | 860 | 1440 | 1.6663 | 0.0000 | |
| GSE63941 | RUNX2 | 860 | 232231_at | -1.1143 | 0.4002 | |
| GSE77861 | RUNX2 | 860 | 236859_at | 0.0172 | 0.8905 | |
| GSE97050 | RUNX2 | 860 | A_33_P3316508 | 2.0417 | 0.0828 | |
| SRP007169 | RUNX2 | 860 | RNAseq | 3.1972 | 0.0001 | |
| SRP008496 | RUNX2 | 860 | RNAseq | 3.6036 | 0.0002 | |
| SRP064894 | RUNX2 | 860 | RNAseq | 2.6631 | 0.0000 | |
| SRP133303 | RUNX2 | 860 | RNAseq | 1.9118 | 0.0000 | |
| SRP159526 | RUNX2 | 860 | RNAseq | 1.4657 | 0.0116 | |
| SRP193095 | RUNX2 | 860 | RNAseq | 1.2476 | 0.0000 | |
| SRP219564 | RUNX2 | 860 | RNAseq | 1.7476 | 0.0019 | |
| TCGA | RUNX2 | 860 | RNAseq | 0.6335 | 0.0000 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by RUNX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RUNX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RUNX2 | 860 | 6 | 2 | 22 | |
| GSE20123 | RUNX2 | 860 | 6 | 2 | 22 | |
| GSE43470 | RUNX2 | 860 | 6 | 0 | 37 | |
| GSE46452 | RUNX2 | 860 | 2 | 10 | 47 | |
| GSE47630 | RUNX2 | 860 | 8 | 4 | 28 | |
| GSE54993 | RUNX2 | 860 | 3 | 2 | 65 | |
| GSE54994 | RUNX2 | 860 | 9 | 3 | 41 | |
| GSE60625 | RUNX2 | 860 | 0 | 3 | 8 | |
| GSE74703 | RUNX2 | 860 | 6 | 0 | 30 | |
| GSE74704 | RUNX2 | 860 | 2 | 1 | 17 | |
| TCGA | RUNX2 | 860 | 19 | 16 | 61 |
Total number of gains: 67; Total number of losses: 43; Total Number of normals: 378.
Somatic mutations of RUNX2:
Generating mutation plots.
Highly correlated genes for RUNX2:
Showing top 20/1103 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RUNX2 | FOXN3-AS2 | 0.766889 | 4 | 0 | 4 |
| RUNX2 | CCR7 | 0.766848 | 3 | 0 | 3 |
| RUNX2 | MMP1 | 0.753378 | 6 | 0 | 6 |
| RUNX2 | LIMK1 | 0.751632 | 3 | 0 | 3 |
| RUNX2 | CMTM3 | 0.751529 | 6 | 0 | 5 |
| RUNX2 | CTHRC1 | 0.749649 | 7 | 0 | 7 |
| RUNX2 | RAC2 | 0.746199 | 6 | 0 | 6 |
| RUNX2 | KHDRBS2 | 0.744813 | 4 | 0 | 4 |
| RUNX2 | ATG10 | 0.743342 | 5 | 0 | 5 |
| RUNX2 | MTHFD1L | 0.734975 | 4 | 0 | 4 |
| RUNX2 | LUZP4 | 0.730546 | 4 | 0 | 4 |
| RUNX2 | SDK1 | 0.728474 | 4 | 0 | 4 |
| RUNX2 | AGRN | 0.725645 | 5 | 0 | 5 |
| RUNX2 | TTYH3 | 0.72067 | 6 | 0 | 5 |
| RUNX2 | TXNDC12 | 0.716779 | 5 | 0 | 5 |
| RUNX2 | GPX8 | 0.716544 | 6 | 0 | 6 |
| RUNX2 | SLC5A4 | 0.713562 | 4 | 0 | 4 |
| RUNX2 | CD2 | 0.709543 | 3 | 0 | 3 |
| RUNX2 | CAMKV | 0.708945 | 4 | 0 | 4 |
| RUNX2 | NEUROD6 | 0.708218 | 4 | 0 | 4 |
For details and further investigation, click here
