| Full name: integrin subunit alpha L | Alias Symbol: LFA-1 | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 3683 | HGNC ID: HGNC:6148 | Ensembl Gene: ENSG00000005844 | OMIM ID: 153370 |
| Drug and gene relationship at DGIdb | |||
ITGAL involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04015 | Rap1 signaling pathway | |
| hsa04650 | Natural killer cell mediated cytotoxicity | |
| hsa04670 | Leukocyte transendothelial migration | |
| hsa04810 | Regulation of actin cytoskeleton |
Expression of ITGAL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITGAL | 3683 | 1554240_a_at | 0.1067 | 0.9561 | |
| GSE20347 | ITGAL | 3683 | 213475_s_at | -0.1502 | 0.1513 | |
| GSE23400 | ITGAL | 3683 | 213475_s_at | -0.0660 | 0.0499 | |
| GSE26886 | ITGAL | 3683 | 213475_s_at | 0.0204 | 0.9134 | |
| GSE29001 | ITGAL | 3683 | 213475_s_at | 0.0193 | 0.9339 | |
| GSE38129 | ITGAL | 3683 | 213475_s_at | -0.2170 | 0.1535 | |
| GSE45670 | ITGAL | 3683 | 213475_s_at | -0.1275 | 0.4798 | |
| GSE53622 | ITGAL | 3683 | 97106 | 0.2045 | 0.0697 | |
| GSE53624 | ITGAL | 3683 | 97106 | 0.0434 | 0.6124 | |
| GSE63941 | ITGAL | 3683 | 213475_s_at | 0.1995 | 0.2355 | |
| GSE77861 | ITGAL | 3683 | 213475_s_at | -0.1266 | 0.3045 | |
| GSE97050 | ITGAL | 3683 | A_23_P206806 | 0.5973 | 0.1857 | |
| SRP007169 | ITGAL | 3683 | RNAseq | 0.4962 | 0.5258 | |
| SRP064894 | ITGAL | 3683 | RNAseq | -0.0481 | 0.8820 | |
| SRP133303 | ITGAL | 3683 | RNAseq | -0.3350 | 0.2126 | |
| SRP159526 | ITGAL | 3683 | RNAseq | -1.1011 | 0.2117 | |
| SRP193095 | ITGAL | 3683 | RNAseq | -0.4900 | 0.0118 | |
| SRP219564 | ITGAL | 3683 | RNAseq | 0.4748 | 0.3913 | |
| TCGA | ITGAL | 3683 | RNAseq | 0.0104 | 0.9534 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ITGAL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ITGAL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITGAL | 3683 | 5 | 5 | 20 | |
| GSE20123 | ITGAL | 3683 | 5 | 4 | 21 | |
| GSE43470 | ITGAL | 3683 | 3 | 3 | 37 | |
| GSE46452 | ITGAL | 3683 | 38 | 1 | 20 | |
| GSE47630 | ITGAL | 3683 | 11 | 7 | 22 | |
| GSE54993 | ITGAL | 3683 | 2 | 5 | 63 | |
| GSE54994 | ITGAL | 3683 | 5 | 9 | 39 | |
| GSE60625 | ITGAL | 3683 | 4 | 0 | 7 | |
| GSE74703 | ITGAL | 3683 | 3 | 2 | 31 | |
| GSE74704 | ITGAL | 3683 | 3 | 2 | 15 | |
| TCGA | ITGAL | 3683 | 20 | 10 | 66 |
Total number of gains: 99; Total number of losses: 48; Total Number of normals: 341.
Somatic mutations of ITGAL:
Generating mutation plots.
Highly correlated genes for ITGAL:
Showing top 20/321 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITGAL | TNFSF10 | 0.753821 | 3 | 0 | 3 |
| ITGAL | CD48 | 0.741989 | 12 | 0 | 11 |
| ITGAL | ZC3H12D | 0.726989 | 4 | 0 | 3 |
| ITGAL | SASH3 | 0.724252 | 12 | 0 | 10 |
| ITGAL | CD3D | 0.719321 | 13 | 0 | 12 |
| ITGAL | MIR205HG | 0.716348 | 3 | 0 | 3 |
| ITGAL | ATP10B | 0.712816 | 3 | 0 | 3 |
| ITGAL | CD27 | 0.710413 | 8 | 0 | 8 |
| ITGAL | CD2 | 0.706253 | 12 | 0 | 12 |
| ITGAL | CORO1A | 0.706217 | 12 | 0 | 12 |
| ITGAL | IL2RB | 0.703067 | 10 | 0 | 9 |
| ITGAL | CD247 | 0.700851 | 10 | 0 | 10 |
| ITGAL | ITGB2-AS1 | 0.698017 | 4 | 0 | 3 |
| ITGAL | GPR174 | 0.697366 | 4 | 0 | 3 |
| ITGAL | LCK | 0.692053 | 12 | 0 | 11 |
| ITGAL | SLAMF6 | 0.688007 | 7 | 0 | 5 |
| ITGAL | PARVG | 0.685557 | 7 | 0 | 6 |
| ITGAL | NLRC3 | 0.681898 | 8 | 0 | 6 |
| ITGAL | PTPRCAP | 0.681046 | 10 | 0 | 9 |
| ITGAL | CD53 | 0.679784 | 9 | 0 | 9 |
For details and further investigation, click here
