| Full name: lymphotoxin beta | Alias Symbol: p33|TNFSF3 | ||
| Type: protein-coding gene | Cytoband: 6p21.33 | ||
| Entrez ID: 4050 | HGNC ID: HGNC:6711 | Ensembl Gene: ENSG00000227507 | OMIM ID: 600978 |
| Drug and gene relationship at DGIdb | |||
LTB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04064 | NF-kappa B signaling pathway |
Expression of LTB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LTB | 4050 | 207339_s_at | 0.0109 | 0.9930 | |
| GSE20347 | LTB | 4050 | 207339_s_at | 0.0615 | 0.8095 | |
| GSE23400 | LTB | 4050 | 207339_s_at | -0.0419 | 0.6823 | |
| GSE26886 | LTB | 4050 | 207339_s_at | -0.0212 | 0.9718 | |
| GSE29001 | LTB | 4050 | 207339_s_at | 0.4396 | 0.1599 | |
| GSE38129 | LTB | 4050 | 207339_s_at | 0.0815 | 0.7578 | |
| GSE45670 | LTB | 4050 | 207339_s_at | 0.2601 | 0.4335 | |
| GSE53622 | LTB | 4050 | 75646 | 0.0173 | 0.8913 | |
| GSE53624 | LTB | 4050 | 17626 | -0.7154 | 0.0000 | |
| GSE63941 | LTB | 4050 | 207339_s_at | -0.0237 | 0.8984 | |
| GSE77861 | LTB | 4050 | 1559754_at | -0.0521 | 0.6610 | |
| GSE97050 | LTB | 4050 | A_33_P3248265 | 1.2017 | 0.1585 | |
| SRP064894 | LTB | 4050 | RNAseq | 1.1686 | 0.0033 | |
| SRP133303 | LTB | 4050 | RNAseq | -0.7026 | 0.0640 | |
| SRP159526 | LTB | 4050 | RNAseq | -0.7478 | 0.2755 | |
| SRP219564 | LTB | 4050 | RNAseq | 1.0528 | 0.0473 | |
| TCGA | LTB | 4050 | RNAseq | 0.5273 | 0.0289 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LTB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LTB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LTB | 4050 | 5 | 1 | 24 | |
| GSE20123 | LTB | 4050 | 5 | 1 | 24 | |
| GSE43470 | LTB | 4050 | 6 | 3 | 34 | |
| GSE46452 | LTB | 4050 | 1 | 10 | 48 | |
| GSE47630 | LTB | 4050 | 7 | 5 | 28 | |
| GSE54993 | LTB | 4050 | 2 | 1 | 67 | |
| GSE54994 | LTB | 4050 | 11 | 4 | 38 | |
| GSE60625 | LTB | 4050 | 0 | 1 | 10 | |
| GSE74703 | LTB | 4050 | 6 | 1 | 29 | |
| GSE74704 | LTB | 4050 | 2 | 0 | 18 | |
| TCGA | LTB | 4050 | 16 | 16 | 64 |
Total number of gains: 61; Total number of losses: 43; Total Number of normals: 384.
Somatic mutations of LTB:
Generating mutation plots.
Highly correlated genes for LTB:
Showing top 20/312 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LTB | P2RY8 | 0.819171 | 4 | 0 | 4 |
| LTB | ITGB2-AS1 | 0.777797 | 3 | 0 | 3 |
| LTB | JAK3 | 0.740768 | 5 | 0 | 5 |
| LTB | GCNT1 | 0.71265 | 3 | 0 | 3 |
| LTB | SLAMF6 | 0.703827 | 6 | 0 | 5 |
| LTB | CORO1A | 0.699498 | 12 | 0 | 10 |
| LTB | CCR7 | 0.697488 | 11 | 0 | 10 |
| LTB | PVRIG | 0.696272 | 6 | 0 | 5 |
| LTB | C1orf162 | 0.688892 | 5 | 0 | 4 |
| LTB | APBB1IP | 0.683733 | 6 | 0 | 5 |
| LTB | CD53 | 0.68352 | 8 | 0 | 7 |
| LTB | CR1 | 0.681724 | 3 | 0 | 3 |
| LTB | SNX20 | 0.678568 | 6 | 0 | 5 |
| LTB | BTLA | 0.677608 | 6 | 0 | 4 |
| LTB | UBE2Z | 0.676441 | 3 | 0 | 3 |
| LTB | TBC1D10C | 0.675706 | 5 | 0 | 4 |
| LTB | SASH3 | 0.671672 | 12 | 0 | 10 |
| LTB | ARHGDIB | 0.668479 | 11 | 0 | 11 |
| LTB | LINC01215 | 0.668257 | 5 | 0 | 4 |
| LTB | GLRX | 0.666119 | 4 | 0 | 3 |
For details and further investigation, click here
