| Full name: IL2 inducible T cell kinase | Alias Symbol: EMT|PSCTK2|LYK | ||
| Type: protein-coding gene | Cytoband: 5q33.3 | ||
| Entrez ID: 3702 | HGNC ID: HGNC:6171 | Ensembl Gene: ENSG00000113263 | OMIM ID: 186973 |
| Drug and gene relationship at DGIdb | |||
ITK involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway | |
| hsa04660 | T cell receptor signaling pathway | |
| hsa04670 | Leukocyte transendothelial migration |
Expression of ITK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITK | 3702 | 211339_s_at | 0.1382 | 0.9526 | |
| GSE20347 | ITK | 3702 | 211339_s_at | -0.1367 | 0.3082 | |
| GSE23400 | ITK | 3702 | 211339_s_at | -0.0953 | 0.1726 | |
| GSE26886 | ITK | 3702 | 211339_s_at | -0.4220 | 0.1263 | |
| GSE29001 | ITK | 3702 | 211339_s_at | 0.0180 | 0.9435 | |
| GSE38129 | ITK | 3702 | 211339_s_at | -0.2183 | 0.3438 | |
| GSE45670 | ITK | 3702 | 211339_s_at | -0.4602 | 0.1156 | |
| GSE53622 | ITK | 3702 | 70782 | -0.5605 | 0.0042 | |
| GSE53624 | ITK | 3702 | 70782 | -0.9107 | 0.0000 | |
| GSE63941 | ITK | 3702 | 211339_s_at | 0.0411 | 0.7758 | |
| GSE77861 | ITK | 3702 | 211339_s_at | -0.0900 | 0.1878 | |
| GSE97050 | ITK | 3702 | A_23_P354151 | 0.1093 | 0.6682 | |
| SRP064894 | ITK | 3702 | RNAseq | -0.4513 | 0.2695 | |
| SRP133303 | ITK | 3702 | RNAseq | -0.7590 | 0.0086 | |
| SRP159526 | ITK | 3702 | RNAseq | -1.4073 | 0.1269 | |
| SRP193095 | ITK | 3702 | RNAseq | -0.2079 | 0.4877 | |
| SRP219564 | ITK | 3702 | RNAseq | 0.1473 | 0.8044 | |
| TCGA | ITK | 3702 | RNAseq | -0.3213 | 0.1848 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ITK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ITK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITK | 3702 | 0 | 11 | 19 | |
| GSE20123 | ITK | 3702 | 0 | 11 | 19 | |
| GSE43470 | ITK | 3702 | 2 | 11 | 30 | |
| GSE46452 | ITK | 3702 | 0 | 27 | 32 | |
| GSE47630 | ITK | 3702 | 0 | 20 | 20 | |
| GSE54993 | ITK | 3702 | 9 | 1 | 60 | |
| GSE54994 | ITK | 3702 | 1 | 16 | 36 | |
| GSE60625 | ITK | 3702 | 0 | 0 | 11 | |
| GSE74703 | ITK | 3702 | 2 | 8 | 26 | |
| GSE74704 | ITK | 3702 | 0 | 6 | 14 | |
| TCGA | ITK | 3702 | 4 | 36 | 56 |
Total number of gains: 18; Total number of losses: 147; Total Number of normals: 323.
Somatic mutations of ITK:
Generating mutation plots.
Highly correlated genes for ITK:
Showing top 20/423 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITK | GIMAP5 | 0.821662 | 4 | 0 | 4 |
| ITK | CCR4 | 0.788367 | 4 | 0 | 4 |
| ITK | ARHGAP15 | 0.781955 | 4 | 0 | 4 |
| ITK | C16orf54 | 0.773432 | 6 | 0 | 6 |
| ITK | GPR171 | 0.767393 | 11 | 0 | 10 |
| ITK | IRF8 | 0.760313 | 10 | 0 | 10 |
| ITK | CD33 | 0.755319 | 3 | 0 | 3 |
| ITK | SLAMF6 | 0.753167 | 6 | 0 | 6 |
| ITK | TAGAP | 0.752908 | 5 | 0 | 5 |
| ITK | GIMAP7 | 0.744792 | 7 | 0 | 7 |
| ITK | SNX20 | 0.743537 | 6 | 0 | 6 |
| ITK | DOCK2 | 0.742556 | 9 | 0 | 9 |
| ITK | CD53 | 0.741488 | 8 | 0 | 8 |
| ITK | PIK3CG | 0.741062 | 8 | 0 | 8 |
| ITK | CD48 | 0.737647 | 11 | 0 | 9 |
| ITK | C1orf162 | 0.737609 | 6 | 0 | 5 |
| ITK | BTLA | 0.737032 | 6 | 0 | 5 |
| ITK | RAB39B | 0.732137 | 4 | 0 | 4 |
| ITK | NCKAP1L | 0.730515 | 10 | 0 | 10 |
| ITK | KLRG1 | 0.729974 | 4 | 0 | 4 |
For details and further investigation, click here
