| Full name: Janus kinase 3 | Alias Symbol: L-JAK|JAKL|LJAK|JAK3_HUMAN|JAK-3 | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 3718 | HGNC ID: HGNC:6193 | Ensembl Gene: ENSG00000105639 | OMIM ID: 600173 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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JAK3 involved pathways:
Expression of JAK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | JAK3 | 3718 | 227677_at | 0.6659 | 0.5372 | |
| GSE20347 | JAK3 | 3718 | 207187_at | 0.0796 | 0.4350 | |
| GSE23400 | JAK3 | 3718 | 207187_at | -0.1735 | 0.0000 | |
| GSE26886 | JAK3 | 3718 | 207187_at | 0.0965 | 0.5254 | |
| GSE29001 | JAK3 | 3718 | 207187_at | -0.1729 | 0.3891 | |
| GSE38129 | JAK3 | 3718 | 207187_at | -0.0804 | 0.4517 | |
| GSE45670 | JAK3 | 3718 | 227677_at | 0.5091 | 0.0405 | |
| GSE53622 | JAK3 | 3718 | 36034 | 0.4130 | 0.0008 | |
| GSE53624 | JAK3 | 3718 | 36034 | -0.0895 | 0.3686 | |
| GSE63941 | JAK3 | 3718 | 207187_at | 0.1781 | 0.3356 | |
| GSE77861 | JAK3 | 3718 | 207187_at | -0.0012 | 0.9941 | |
| GSE97050 | JAK3 | 3718 | A_23_P329112 | 1.1685 | 0.1756 | |
| SRP007169 | JAK3 | 3718 | RNAseq | 0.8264 | 0.1144 | |
| SRP008496 | JAK3 | 3718 | RNAseq | 0.5774 | 0.1256 | |
| SRP064894 | JAK3 | 3718 | RNAseq | 1.0490 | 0.0003 | |
| SRP133303 | JAK3 | 3718 | RNAseq | 0.0033 | 0.9890 | |
| SRP159526 | JAK3 | 3718 | RNAseq | -0.4059 | 0.3957 | |
| SRP193095 | JAK3 | 3718 | RNAseq | 0.6618 | 0.0197 | |
| SRP219564 | JAK3 | 3718 | RNAseq | 0.4248 | 0.3730 | |
| TCGA | JAK3 | 3718 | RNAseq | 0.0786 | 0.5309 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by JAK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of JAK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | JAK3 | 3718 | 4 | 4 | 22 | |
| GSE20123 | JAK3 | 3718 | 3 | 2 | 25 | |
| GSE43470 | JAK3 | 3718 | 2 | 6 | 35 | |
| GSE46452 | JAK3 | 3718 | 47 | 1 | 11 | |
| GSE47630 | JAK3 | 3718 | 4 | 8 | 28 | |
| GSE54993 | JAK3 | 3718 | 15 | 4 | 51 | |
| GSE54994 | JAK3 | 3718 | 6 | 14 | 33 | |
| GSE60625 | JAK3 | 3718 | 9 | 0 | 2 | |
| GSE74703 | JAK3 | 3718 | 2 | 4 | 30 | |
| GSE74704 | JAK3 | 3718 | 0 | 2 | 18 | |
| TCGA | JAK3 | 3718 | 17 | 9 | 70 |
Total number of gains: 109; Total number of losses: 54; Total Number of normals: 325.
Somatic mutations of JAK3:
Generating mutation plots.
Highly correlated genes for JAK3:
Showing top 20/945 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| JAK3 | RET | 0.785007 | 3 | 0 | 3 |
| JAK3 | IL2RG | 0.784843 | 6 | 0 | 5 |
| JAK3 | GAD2 | 0.774107 | 4 | 0 | 4 |
| JAK3 | KHDRBS2 | 0.750443 | 4 | 0 | 4 |
| JAK3 | ELSPBP1 | 0.746807 | 4 | 0 | 4 |
| JAK3 | CORO1A | 0.744778 | 5 | 0 | 5 |
| JAK3 | NEU3 | 0.742608 | 5 | 0 | 5 |
| JAK3 | RAI1 | 0.741958 | 4 | 0 | 4 |
| JAK3 | LTB | 0.740768 | 5 | 0 | 5 |
| JAK3 | RNF185-AS1 | 0.739212 | 4 | 0 | 4 |
| JAK3 | ACAP1 | 0.738382 | 4 | 0 | 4 |
| JAK3 | FMNL1 | 0.736649 | 5 | 0 | 4 |
| JAK3 | NEUROD2 | 0.736058 | 4 | 0 | 4 |
| JAK3 | ODF1 | 0.735486 | 4 | 0 | 4 |
| JAK3 | NOS1 | 0.72599 | 3 | 0 | 3 |
| JAK3 | ZNF460 | 0.724943 | 4 | 0 | 4 |
| JAK3 | IL2RB | 0.722352 | 5 | 0 | 4 |
| JAK3 | TAF6L | 0.720291 | 4 | 0 | 3 |
| JAK3 | MYO1F | 0.717592 | 6 | 0 | 6 |
| JAK3 | CCR7 | 0.715643 | 6 | 0 | 6 |
For details and further investigation, click here
