| Full name: deoxyhypusine hydroxylase | Alias Symbol: MGC4293 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 83475 | HGNC ID: HGNC:28662 | Ensembl Gene: ENSG00000129932 | OMIM ID: 611262 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of DOHH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DOHH | 83475 | 208141_s_at | 0.3184 | 0.3849 | |
| GSE20347 | DOHH | 83475 | 208141_s_at | 0.0233 | 0.8479 | |
| GSE23400 | DOHH | 83475 | 208141_s_at | 0.1011 | 0.1229 | |
| GSE26886 | DOHH | 83475 | 208141_s_at | 0.6189 | 0.0004 | |
| GSE29001 | DOHH | 83475 | 208141_s_at | 0.0920 | 0.8951 | |
| GSE38129 | DOHH | 83475 | 208141_s_at | 0.0434 | 0.6780 | |
| GSE45670 | DOHH | 83475 | 208141_s_at | 0.1064 | 0.2813 | |
| GSE63941 | DOHH | 83475 | 208141_s_at | 0.1303 | 0.6536 | |
| GSE77861 | DOHH | 83475 | 208141_s_at | 0.1427 | 0.4739 | |
| GSE97050 | DOHH | 83475 | A_23_P125408 | 0.0344 | 0.8778 | |
| SRP007169 | DOHH | 83475 | RNAseq | -0.0399 | 0.9358 | |
| SRP008496 | DOHH | 83475 | RNAseq | 0.2404 | 0.5292 | |
| SRP064894 | DOHH | 83475 | RNAseq | 0.7276 | 0.0259 | |
| SRP133303 | DOHH | 83475 | RNAseq | 0.3040 | 0.1942 | |
| SRP159526 | DOHH | 83475 | RNAseq | 0.1919 | 0.4339 | |
| SRP193095 | DOHH | 83475 | RNAseq | 0.2538 | 0.0635 | |
| SRP219564 | DOHH | 83475 | RNAseq | 0.3788 | 0.2780 | |
| TCGA | DOHH | 83475 | RNAseq | 0.1425 | 0.0348 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DOHH expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of DOHH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DOHH | 83475 | 5 | 4 | 21 | |
| GSE20123 | DOHH | 83475 | 4 | 3 | 23 | |
| GSE43470 | DOHH | 83475 | 1 | 9 | 33 | |
| GSE46452 | DOHH | 83475 | 47 | 1 | 11 | |
| GSE47630 | DOHH | 83475 | 5 | 7 | 28 | |
| GSE54993 | DOHH | 83475 | 16 | 3 | 51 | |
| GSE54994 | DOHH | 83475 | 8 | 16 | 29 | |
| GSE60625 | DOHH | 83475 | 9 | 0 | 2 | |
| GSE74703 | DOHH | 83475 | 1 | 6 | 29 | |
| GSE74704 | DOHH | 83475 | 1 | 3 | 16 | |
| TCGA | DOHH | 83475 | 10 | 19 | 67 |
Total number of gains: 107; Total number of losses: 71; Total Number of normals: 310.
Somatic mutations of DOHH:
Generating mutation plots.
Highly correlated genes for DOHH:
Showing top 20/331 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DOHH | ZMYND15 | 0.822073 | 3 | 0 | 3 |
| DOHH | RASL10B | 0.793191 | 3 | 0 | 3 |
| DOHH | MGAT5B | 0.789074 | 3 | 0 | 3 |
| DOHH | DNLZ | 0.782083 | 3 | 0 | 3 |
| DOHH | GTF2IRD2 | 0.779376 | 3 | 0 | 3 |
| DOHH | TAF5L | 0.761407 | 3 | 0 | 3 |
| DOHH | YEATS2 | 0.758219 | 3 | 0 | 3 |
| DOHH | SEC62 | 0.744409 | 3 | 0 | 3 |
| DOHH | RIMS4 | 0.738698 | 3 | 0 | 3 |
| DOHH | GALNS | 0.73842 | 3 | 0 | 3 |
| DOHH | EDA | 0.728355 | 3 | 0 | 3 |
| DOHH | TMEM120B | 0.727634 | 5 | 0 | 5 |
| DOHH | BEND3 | 0.726286 | 3 | 0 | 3 |
| DOHH | FBXO44 | 0.725718 | 4 | 0 | 4 |
| DOHH | FBRSL1 | 0.723879 | 4 | 0 | 3 |
| DOHH | CDC42EP2 | 0.72213 | 3 | 0 | 3 |
| DOHH | TIGD5 | 0.72008 | 5 | 0 | 5 |
| DOHH | OBSL1 | 0.719733 | 3 | 0 | 3 |
| DOHH | CPAMD8 | 0.714758 | 4 | 0 | 3 |
| DOHH | ARID3A | 0.714362 | 3 | 0 | 3 |
For details and further investigation, click here
