| Full name: CDC42 binding protein kinase alpha | Alias Symbol: MRCKA|PK428|FLJ23347|KIAA0451|MRCK | ||
| Type: protein-coding gene | Cytoband: 1q42.13 | ||
| Entrez ID: 8476 | HGNC ID: HGNC:1737 | Ensembl Gene: ENSG00000143776 | OMIM ID: 603412 |
| Drug and gene relationship at DGIdb | |||
Expression of CDC42BPA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDC42BPA | 8476 | 214464_at | 0.0278 | 0.9862 | |
| GSE20347 | CDC42BPA | 8476 | 203794_at | -0.0288 | 0.8498 | |
| GSE23400 | CDC42BPA | 8476 | 203794_at | -0.3145 | 0.0000 | |
| GSE26886 | CDC42BPA | 8476 | 214464_at | 0.5175 | 0.1135 | |
| GSE29001 | CDC42BPA | 8476 | 214464_at | 0.3970 | 0.5422 | |
| GSE38129 | CDC42BPA | 8476 | 203794_at | -0.3686 | 0.0358 | |
| GSE45670 | CDC42BPA | 8476 | 214464_at | -0.1851 | 0.7379 | |
| GSE53622 | CDC42BPA | 8476 | 22954 | -0.2057 | 0.1237 | |
| GSE53624 | CDC42BPA | 8476 | 22954 | 0.1027 | 0.4144 | |
| GSE63941 | CDC42BPA | 8476 | 203794_at | -1.4180 | 0.0042 | |
| GSE77861 | CDC42BPA | 8476 | 203794_at | 0.1337 | 0.5717 | |
| GSE97050 | CDC42BPA | 8476 | A_24_P944299 | -0.3157 | 0.4358 | |
| SRP007169 | CDC42BPA | 8476 | RNAseq | 2.1991 | 0.0000 | |
| SRP008496 | CDC42BPA | 8476 | RNAseq | 2.6326 | 0.0000 | |
| SRP064894 | CDC42BPA | 8476 | RNAseq | 0.2229 | 0.2509 | |
| SRP133303 | CDC42BPA | 8476 | RNAseq | 0.5396 | 0.0003 | |
| SRP159526 | CDC42BPA | 8476 | RNAseq | 0.0934 | 0.7643 | |
| SRP193095 | CDC42BPA | 8476 | RNAseq | 0.3804 | 0.1789 | |
| SRP219564 | CDC42BPA | 8476 | RNAseq | -0.1301 | 0.8019 | |
| TCGA | CDC42BPA | 8476 | RNAseq | -0.3846 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by CDC42BPA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDC42BPA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDC42BPA | 8476 | 11 | 0 | 19 | |
| GSE20123 | CDC42BPA | 8476 | 11 | 0 | 19 | |
| GSE43470 | CDC42BPA | 8476 | 7 | 1 | 35 | |
| GSE46452 | CDC42BPA | 8476 | 3 | 1 | 55 | |
| GSE47630 | CDC42BPA | 8476 | 15 | 0 | 25 | |
| GSE54993 | CDC42BPA | 8476 | 0 | 6 | 64 | |
| GSE54994 | CDC42BPA | 8476 | 16 | 0 | 37 | |
| GSE60625 | CDC42BPA | 8476 | 0 | 0 | 11 | |
| GSE74703 | CDC42BPA | 8476 | 7 | 1 | 28 | |
| GSE74704 | CDC42BPA | 8476 | 5 | 0 | 15 | |
| TCGA | CDC42BPA | 8476 | 46 | 3 | 47 |
Total number of gains: 121; Total number of losses: 12; Total Number of normals: 355.
Somatic mutations of CDC42BPA:
Generating mutation plots.
Highly correlated genes for CDC42BPA:
Showing top 20/696 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDC42BPA | ITIH5 | 0.746923 | 3 | 0 | 3 |
| CDC42BPA | ZC3H15 | 0.740103 | 3 | 0 | 3 |
| CDC42BPA | CNST | 0.739729 | 3 | 0 | 3 |
| CDC42BPA | TNFSF12 | 0.723771 | 3 | 0 | 3 |
| CDC42BPA | ZNF462 | 0.722392 | 3 | 0 | 3 |
| CDC42BPA | C2orf49 | 0.717844 | 3 | 0 | 3 |
| CDC42BPA | KLHL20 | 0.717783 | 5 | 0 | 5 |
| CDC42BPA | ZNF124 | 0.714472 | 4 | 0 | 4 |
| CDC42BPA | SAMHD1 | 0.71436 | 3 | 0 | 3 |
| CDC42BPA | RHOU | 0.704464 | 3 | 0 | 3 |
| CDC42BPA | PEG3 | 0.702181 | 4 | 0 | 4 |
| CDC42BPA | ZNF583 | 0.701164 | 3 | 0 | 3 |
| CDC42BPA | LETM2 | 0.699893 | 3 | 0 | 3 |
| CDC42BPA | ABCA8 | 0.699033 | 4 | 0 | 4 |
| CDC42BPA | MRFAP1 | 0.694858 | 4 | 0 | 3 |
| CDC42BPA | MAPK1IP1L | 0.692767 | 3 | 0 | 3 |
| CDC42BPA | CNTLN | 0.689488 | 4 | 0 | 3 |
| CDC42BPA | ZEB1 | 0.688562 | 3 | 0 | 3 |
| CDC42BPA | ZNF382 | 0.68343 | 3 | 0 | 3 |
| CDC42BPA | ATP10A | 0.682561 | 5 | 0 | 4 |
For details and further investigation, click here
