| Full name: SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Alias Symbol: SBBI88|Mg11|HDDC1|MOP-5|AGS5 | ||
| Type: protein-coding gene | Cytoband: 20q11.23 | ||
| Entrez ID: 25939 | HGNC ID: HGNC:15925 | Ensembl Gene: ENSG00000101347 | OMIM ID: 606754 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SAMHD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SAMHD1 | 25939 | 235529_x_at | -0.6877 | 0.3629 | |
| GSE20347 | SAMHD1 | 25939 | 204502_at | -0.6466 | 0.0007 | |
| GSE23400 | SAMHD1 | 25939 | 204502_at | -0.1171 | 0.1408 | |
| GSE26886 | SAMHD1 | 25939 | 235529_x_at | -1.0429 | 0.0036 | |
| GSE29001 | SAMHD1 | 25939 | 204502_at | -0.3892 | 0.3507 | |
| GSE38129 | SAMHD1 | 25939 | 204502_at | -0.8378 | 0.0002 | |
| GSE45670 | SAMHD1 | 25939 | 235529_x_at | -0.1674 | 0.6558 | |
| GSE53622 | SAMHD1 | 25939 | 28627 | -0.7732 | 0.0000 | |
| GSE53624 | SAMHD1 | 25939 | 28627 | -0.8001 | 0.0000 | |
| GSE63941 | SAMHD1 | 25939 | 235529_x_at | -0.8690 | 0.3114 | |
| GSE77861 | SAMHD1 | 25939 | 235529_x_at | -0.7213 | 0.1379 | |
| GSE97050 | SAMHD1 | 25939 | A_33_P3406281 | 0.1140 | 0.6542 | |
| SRP007169 | SAMHD1 | 25939 | RNAseq | -0.6775 | 0.2586 | |
| SRP008496 | SAMHD1 | 25939 | RNAseq | -0.6844 | 0.0406 | |
| SRP064894 | SAMHD1 | 25939 | RNAseq | 0.0523 | 0.8728 | |
| SRP133303 | SAMHD1 | 25939 | RNAseq | -0.4287 | 0.0904 | |
| SRP159526 | SAMHD1 | 25939 | RNAseq | -1.0262 | 0.0796 | |
| SRP193095 | SAMHD1 | 25939 | RNAseq | -0.1926 | 0.1771 | |
| SRP219564 | SAMHD1 | 25939 | RNAseq | -0.1126 | 0.8606 | |
| TCGA | SAMHD1 | 25939 | RNAseq | -0.2765 | 0.0084 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SAMHD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SAMHD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SAMHD1 | 25939 | 14 | 2 | 14 | |
| GSE20123 | SAMHD1 | 25939 | 14 | 2 | 14 | |
| GSE43470 | SAMHD1 | 25939 | 12 | 0 | 31 | |
| GSE46452 | SAMHD1 | 25939 | 29 | 0 | 30 | |
| GSE47630 | SAMHD1 | 25939 | 24 | 0 | 16 | |
| GSE54993 | SAMHD1 | 25939 | 0 | 17 | 53 | |
| GSE54994 | SAMHD1 | 25939 | 24 | 0 | 29 | |
| GSE60625 | SAMHD1 | 25939 | 0 | 0 | 11 | |
| GSE74703 | SAMHD1 | 25939 | 11 | 0 | 25 | |
| GSE74704 | SAMHD1 | 25939 | 10 | 1 | 9 | |
| TCGA | SAMHD1 | 25939 | 47 | 3 | 46 |
Total number of gains: 185; Total number of losses: 25; Total Number of normals: 278.
Somatic mutations of SAMHD1:
Generating mutation plots.
Highly correlated genes for SAMHD1:
Showing top 20/886 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SAMHD1 | MACROD2 | 0.805653 | 3 | 0 | 3 |
| SAMHD1 | GIMAP5 | 0.796773 | 3 | 0 | 3 |
| SAMHD1 | ARHGAP15 | 0.775838 | 3 | 0 | 3 |
| SAMHD1 | ZNF547 | 0.742194 | 3 | 0 | 3 |
| SAMHD1 | FBXL3 | 0.725478 | 3 | 0 | 3 |
| SAMHD1 | CCNYL1 | 0.720578 | 3 | 0 | 3 |
| SAMHD1 | CDC42BPA | 0.71436 | 3 | 0 | 3 |
| SAMHD1 | SLC4A8 | 0.714338 | 3 | 0 | 3 |
| SAMHD1 | ANGPTL6 | 0.708927 | 3 | 0 | 3 |
| SAMHD1 | HDHD2 | 0.705048 | 5 | 0 | 5 |
| SAMHD1 | FRMD3 | 0.689952 | 4 | 0 | 4 |
| SAMHD1 | TNFSF12 | 0.689833 | 3 | 0 | 3 |
| SAMHD1 | SYNE1 | 0.687472 | 6 | 0 | 6 |
| SAMHD1 | ZNF583 | 0.684572 | 4 | 0 | 3 |
| SAMHD1 | NKIRAS1 | 0.684036 | 4 | 0 | 4 |
| SAMHD1 | ANGPTL1 | 0.68023 | 4 | 0 | 4 |
| SAMHD1 | ECSCR | 0.679406 | 3 | 0 | 3 |
| SAMHD1 | ZNF33A | 0.679258 | 4 | 0 | 3 |
| SAMHD1 | KLHDC1 | 0.676295 | 3 | 0 | 3 |
| SAMHD1 | GPBP1 | 0.670725 | 3 | 0 | 3 |
For details and further investigation, click here
