| Full name: ATP binding cassette subfamily A member 8 | Alias Symbol: KIAA0822 | ||
| Type: protein-coding gene | Cytoband: 17q24.2 | ||
| Entrez ID: 10351 | HGNC ID: HGNC:38 | Ensembl Gene: ENSG00000141338 | OMIM ID: 612505 |
| Drug and gene relationship at DGIdb | |||
Expression of ABCA8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABCA8 | 10351 | 204719_at | -3.5098 | 0.0283 | |
| GSE20347 | ABCA8 | 10351 | 204719_at | -1.6558 | 0.0000 | |
| GSE23400 | ABCA8 | 10351 | 204719_at | -1.4023 | 0.0000 | |
| GSE26886 | ABCA8 | 10351 | 204719_at | -1.4968 | 0.0012 | |
| GSE29001 | ABCA8 | 10351 | 204719_at | -1.7506 | 0.0001 | |
| GSE38129 | ABCA8 | 10351 | 204719_at | -2.7110 | 0.0000 | |
| GSE45670 | ABCA8 | 10351 | 204719_at | -4.4106 | 0.0000 | |
| GSE53622 | ABCA8 | 10351 | 3073 | -3.3397 | 0.0000 | |
| GSE53624 | ABCA8 | 10351 | 3073 | -3.3093 | 0.0000 | |
| GSE63941 | ABCA8 | 10351 | 204719_at | -5.8551 | 0.0000 | |
| GSE77861 | ABCA8 | 10351 | 1565778_at | -0.0112 | 0.8965 | |
| GSE97050 | ABCA8 | 10351 | A_33_P3342305 | -1.5298 | 0.0672 | |
| SRP007169 | ABCA8 | 10351 | RNAseq | -2.1096 | 0.0006 | |
| SRP064894 | ABCA8 | 10351 | RNAseq | -1.3148 | 0.0116 | |
| SRP133303 | ABCA8 | 10351 | RNAseq | -2.2555 | 0.0000 | |
| SRP159526 | ABCA8 | 10351 | RNAseq | -1.5557 | 0.0667 | |
| SRP193095 | ABCA8 | 10351 | RNAseq | -1.0108 | 0.0099 | |
| SRP219564 | ABCA8 | 10351 | RNAseq | -0.0309 | 0.9798 | |
| TCGA | ABCA8 | 10351 | RNAseq | -2.3139 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by ABCA8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABCA8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABCA8 | 10351 | 3 | 1 | 26 | |
| GSE20123 | ABCA8 | 10351 | 3 | 1 | 26 | |
| GSE43470 | ABCA8 | 10351 | 6 | 0 | 37 | |
| GSE46452 | ABCA8 | 10351 | 31 | 1 | 27 | |
| GSE47630 | ABCA8 | 10351 | 7 | 1 | 32 | |
| GSE54993 | ABCA8 | 10351 | 2 | 5 | 63 | |
| GSE54994 | ABCA8 | 10351 | 9 | 4 | 40 | |
| GSE60625 | ABCA8 | 10351 | 4 | 3 | 4 | |
| GSE74703 | ABCA8 | 10351 | 6 | 0 | 30 | |
| GSE74704 | ABCA8 | 10351 | 3 | 1 | 16 | |
| TCGA | ABCA8 | 10351 | 30 | 10 | 56 |
Total number of gains: 104; Total number of losses: 27; Total Number of normals: 357.
Somatic mutations of ABCA8:
Generating mutation plots.
Highly correlated genes for ABCA8:
Showing top 20/1560 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABCA8 | FAM13C | 0.893389 | 5 | 0 | 5 |
| ABCA8 | CLEC3B | 0.883199 | 3 | 0 | 3 |
| ABCA8 | TMEM100 | 0.881564 | 10 | 0 | 10 |
| ABCA8 | ASPA | 0.866686 | 11 | 0 | 11 |
| ABCA8 | LINC01279 | 0.843836 | 3 | 0 | 3 |
| ABCA8 | SLC4A4 | 0.842194 | 6 | 0 | 6 |
| ABCA8 | CYP21A2 | 0.837599 | 3 | 0 | 3 |
| ABCA8 | MAGI2-AS3 | 0.835118 | 5 | 0 | 5 |
| ABCA8 | MYOCD | 0.833177 | 6 | 0 | 6 |
| ABCA8 | COL14A1 | 0.825559 | 11 | 0 | 10 |
| ABCA8 | ADAMTS9-AS2 | 0.822661 | 5 | 0 | 5 |
| ABCA8 | ATP1A2 | 0.821443 | 10 | 0 | 9 |
| ABCA8 | MYRIP | 0.817259 | 10 | 0 | 10 |
| ABCA8 | NR2F1 | 0.814436 | 3 | 0 | 3 |
| ABCA8 | FIBIN | 0.812543 | 4 | 0 | 4 |
| ABCA8 | BHMT2 | 0.812246 | 9 | 0 | 9 |
| ABCA8 | CXCL12 | 0.811808 | 11 | 0 | 10 |
| ABCA8 | DPT | 0.80599 | 10 | 0 | 10 |
| ABCA8 | SMOC2 | 0.803843 | 5 | 0 | 5 |
| ABCA8 | ANGPTL1 | 0.802786 | 7 | 0 | 6 |
For details and further investigation, click here
