| Full name: inter-alpha-trypsin inhibitor heavy chain 5 | Alias Symbol: MGC10848 | ||
| Type: protein-coding gene | Cytoband: 10p14 | ||
| Entrez ID: 80760 | HGNC ID: HGNC:21449 | Ensembl Gene: ENSG00000123243 | OMIM ID: 609783 |
| Drug and gene relationship at DGIdb | |||
Expression of ITIH5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITIH5 | 80760 | 219064_at | -1.1443 | 0.2656 | |
| GSE20347 | ITIH5 | 80760 | 219064_at | -0.5694 | 0.0013 | |
| GSE23400 | ITIH5 | 80760 | 219064_at | -0.8233 | 0.0000 | |
| GSE26886 | ITIH5 | 80760 | 219064_at | 0.1582 | 0.6974 | |
| GSE29001 | ITIH5 | 80760 | 219064_at | -0.6928 | 0.0055 | |
| GSE38129 | ITIH5 | 80760 | 219064_at | -1.4487 | 0.0002 | |
| GSE45670 | ITIH5 | 80760 | 219064_at | -1.7115 | 0.0000 | |
| GSE53622 | ITIH5 | 80760 | 103289 | -2.2429 | 0.0000 | |
| GSE53624 | ITIH5 | 80760 | 103289 | -1.9625 | 0.0000 | |
| GSE63941 | ITIH5 | 80760 | 219064_at | -0.1980 | 0.3242 | |
| GSE77861 | ITIH5 | 80760 | 219064_at | 0.1115 | 0.5076 | |
| GSE97050 | ITIH5 | 80760 | A_33_P3420380 | -0.6540 | 0.3225 | |
| SRP007169 | ITIH5 | 80760 | RNAseq | -0.9128 | 0.0777 | |
| SRP064894 | ITIH5 | 80760 | RNAseq | -0.9854 | 0.0087 | |
| SRP133303 | ITIH5 | 80760 | RNAseq | -1.5560 | 0.0000 | |
| SRP159526 | ITIH5 | 80760 | RNAseq | -1.9079 | 0.0010 | |
| SRP193095 | ITIH5 | 80760 | RNAseq | 0.0793 | 0.6121 | |
| SRP219564 | ITIH5 | 80760 | RNAseq | -0.6310 | 0.4315 | |
| TCGA | ITIH5 | 80760 | RNAseq | -1.1348 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by ITIH5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ITIH5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITIH5 | 80760 | 4 | 8 | 18 | |
| GSE20123 | ITIH5 | 80760 | 4 | 7 | 19 | |
| GSE43470 | ITIH5 | 80760 | 3 | 6 | 34 | |
| GSE46452 | ITIH5 | 80760 | 2 | 14 | 43 | |
| GSE47630 | ITIH5 | 80760 | 5 | 15 | 20 | |
| GSE54993 | ITIH5 | 80760 | 11 | 0 | 59 | |
| GSE54994 | ITIH5 | 80760 | 4 | 10 | 39 | |
| GSE60625 | ITIH5 | 80760 | 0 | 0 | 11 | |
| GSE74703 | ITIH5 | 80760 | 2 | 4 | 30 | |
| GSE74704 | ITIH5 | 80760 | 1 | 6 | 13 | |
| TCGA | ITIH5 | 80760 | 19 | 26 | 51 |
Total number of gains: 55; Total number of losses: 96; Total Number of normals: 337.
Somatic mutations of ITIH5:
Generating mutation plots.
Highly correlated genes for ITIH5:
Showing top 20/1260 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITIH5 | CLEC3B | 0.855157 | 3 | 0 | 3 |
| ITIH5 | CYP21A2 | 0.845244 | 3 | 0 | 3 |
| ITIH5 | ANGPTL1 | 0.837633 | 5 | 0 | 5 |
| ITIH5 | ARHGAP6 | 0.818002 | 9 | 0 | 9 |
| ITIH5 | UBXN10 | 0.803157 | 3 | 0 | 3 |
| ITIH5 | LINC01082 | 0.801942 | 4 | 0 | 4 |
| ITIH5 | SORCS1 | 0.797825 | 4 | 0 | 4 |
| ITIH5 | MRVI1 | 0.797546 | 6 | 0 | 6 |
| ITIH5 | LRRN4CL | 0.793394 | 5 | 0 | 5 |
| ITIH5 | KCNT2 | 0.793199 | 6 | 0 | 6 |
| ITIH5 | BHMT2 | 0.791341 | 8 | 0 | 8 |
| ITIH5 | AOC3 | 0.790806 | 10 | 0 | 10 |
| ITIH5 | PDE5A | 0.787127 | 8 | 0 | 8 |
| ITIH5 | RCAN2 | 0.785811 | 11 | 0 | 10 |
| ITIH5 | XKR4 | 0.784095 | 6 | 0 | 6 |
| ITIH5 | DPT | 0.783116 | 9 | 0 | 9 |
| ITIH5 | THAP8 | 0.780542 | 3 | 0 | 3 |
| ITIH5 | GFRA1 | 0.779743 | 6 | 0 | 6 |
| ITIH5 | TMEM100 | 0.779327 | 8 | 0 | 8 |
| ITIH5 | NEGR1 | 0.778689 | 5 | 0 | 5 |
For details and further investigation, click here
