| Full name: hemicentin 1 | Alias Symbol: FBLN6|FIBL6|FIBL-6 | ||
| Type: protein-coding gene | Cytoband: 1q25.3-q31.1 | ||
| Entrez ID: 83872 | HGNC ID: HGNC:19194 | Ensembl Gene: ENSG00000143341 | OMIM ID: 608548 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of HMCN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HMCN1 | 83872 | 235944_at | -1.0583 | 0.2953 | |
| GSE26886 | HMCN1 | 83872 | 235944_at | 2.7793 | 0.0000 | |
| GSE45670 | HMCN1 | 83872 | 235944_at | -2.2970 | 0.0000 | |
| GSE53622 | HMCN1 | 83872 | 63091 | 0.0383 | 0.8706 | |
| GSE53624 | HMCN1 | 83872 | 63091 | -0.0878 | 0.6173 | |
| GSE63941 | HMCN1 | 83872 | 235944_at | -5.3206 | 0.0000 | |
| GSE77861 | HMCN1 | 83872 | 235944_at | 0.5243 | 0.2361 | |
| GSE97050 | HMCN1 | 83872 | A_23_P148990 | -0.6073 | 0.2764 | |
| SRP007169 | HMCN1 | 83872 | RNAseq | 2.5061 | 0.0000 | |
| SRP008496 | HMCN1 | 83872 | RNAseq | 3.6098 | 0.0000 | |
| SRP064894 | HMCN1 | 83872 | RNAseq | 0.6153 | 0.1912 | |
| SRP133303 | HMCN1 | 83872 | RNAseq | 0.0655 | 0.8845 | |
| SRP159526 | HMCN1 | 83872 | RNAseq | 0.1625 | 0.7468 | |
| SRP193095 | HMCN1 | 83872 | RNAseq | 1.2374 | 0.0000 | |
| SRP219564 | HMCN1 | 83872 | RNAseq | 1.3668 | 0.2475 | |
| TCGA | HMCN1 | 83872 | RNAseq | -0.0892 | 0.6384 |
Upregulated datasets: 4; Downregulated datasets: 2.
Survival by HMCN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HMCN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HMCN1 | 83872 | 12 | 0 | 18 | |
| GSE20123 | HMCN1 | 83872 | 12 | 0 | 18 | |
| GSE43470 | HMCN1 | 83872 | 6 | 1 | 36 | |
| GSE46452 | HMCN1 | 83872 | 3 | 1 | 55 | |
| GSE47630 | HMCN1 | 83872 | 14 | 0 | 26 | |
| GSE54993 | HMCN1 | 83872 | 0 | 6 | 64 | |
| GSE54994 | HMCN1 | 83872 | 15 | 0 | 38 | |
| GSE60625 | HMCN1 | 83872 | 0 | 0 | 11 | |
| GSE74703 | HMCN1 | 83872 | 6 | 1 | 29 | |
| GSE74704 | HMCN1 | 83872 | 5 | 0 | 15 | |
| TCGA | HMCN1 | 83872 | 41 | 4 | 51 |
Total number of gains: 114; Total number of losses: 13; Total Number of normals: 361.
Somatic mutations of HMCN1:
Generating mutation plots.
Highly correlated genes for HMCN1:
Showing top 20/1231 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HMCN1 | SYNC | 0.851704 | 4 | 0 | 4 |
| HMCN1 | RASSF3 | 0.845407 | 3 | 0 | 3 |
| HMCN1 | ZCCHC24 | 0.825659 | 7 | 0 | 7 |
| HMCN1 | PRKG1 | 0.786615 | 8 | 0 | 8 |
| HMCN1 | MSRB3 | 0.783965 | 7 | 0 | 7 |
| HMCN1 | COL14A1 | 0.780967 | 5 | 0 | 5 |
| HMCN1 | JAM3 | 0.779154 | 9 | 0 | 8 |
| HMCN1 | SGCE | 0.779092 | 7 | 0 | 7 |
| HMCN1 | MCAM | 0.778461 | 6 | 0 | 6 |
| HMCN1 | PEG3 | 0.776444 | 4 | 0 | 4 |
| HMCN1 | PKIG | 0.775696 | 8 | 0 | 8 |
| HMCN1 | MGARP | 0.775298 | 3 | 0 | 3 |
| HMCN1 | MGAT5 | 0.774572 | 3 | 0 | 3 |
| HMCN1 | LRRN4CL | 0.772973 | 7 | 0 | 7 |
| HMCN1 | CLMP | 0.771844 | 6 | 0 | 6 |
| HMCN1 | FERMT2 | 0.770896 | 9 | 0 | 9 |
| HMCN1 | SGCD | 0.766488 | 7 | 0 | 7 |
| HMCN1 | KCNH2 | 0.7626 | 3 | 0 | 3 |
| HMCN1 | TNFRSF10D | 0.762088 | 4 | 0 | 4 |
| HMCN1 | LRP3 | 0.761686 | 3 | 0 | 3 |
For details and further investigation, click here
