ESCO1

 

Full name: establishment of sister chromatid cohesion N-acetyltransferase 1 Alias Symbol: ESO1|EFO1|KIAA1911
Type: protein-coding gene Cytoband: 18q11.2
Entrez ID: 114799 HGNC ID: HGNC:24645 Ensembl Gene: ENSG00000141446 OMIM ID: 609674
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ESCO1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ESCO1 114799 226866_at 0.3123 0.3353
GSE26886 ESCO1 114799 226866_at 0.6549 0.0002
GSE45670 ESCO1 114799 226866_at 0.2913 0.0050
GSE53622 ESCO1 114799 124484 0.1315 0.0389
GSE53624 ESCO1 114799 124484 0.2771 0.0000
GSE63941 ESCO1 114799 226866_at 0.4990 0.3625
GSE77861 ESCO1 114799 226866_at 0.4468 0.2054
GSE97050 ESCO1 114799 A_23_P317347 -0.0059 0.9898
SRP007169 ESCO1 114799 RNAseq 1.1670 0.0018
SRP008496 ESCO1 114799 RNAseq 0.7090 0.0280
SRP064894 ESCO1 114799 RNAseq -0.3876 0.0845
SRP133303 ESCO1 114799 RNAseq 0.3941 0.0336
SRP159526 ESCO1 114799 RNAseq 0.5005 0.0174
SRP193095 ESCO1 114799 RNAseq -0.0165 0.8441
SRP219564 ESCO1 114799 RNAseq 0.0108 0.9695
TCGA ESCO1 114799 RNAseq 0.1185 0.0410

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by ESCO1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ESCO1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ESCO1 114799 2 5 23
GSE20123 ESCO1 114799 1 5 24
GSE43470 ESCO1 114799 2 1 40
GSE46452 ESCO1 114799 3 22 34
GSE47630 ESCO1 114799 7 17 16
GSE54993 ESCO1 114799 7 1 62
GSE54994 ESCO1 114799 3 12 38
GSE60625 ESCO1 114799 0 4 7
GSE74703 ESCO1 114799 2 1 33
GSE74704 ESCO1 114799 1 4 15
TCGA ESCO1 114799 18 18 60

Total number of gains: 46; Total number of losses: 90; Total Number of normals: 352.  

 

Somatic mutations of ESCO1:

 

Generating mutation plots.

 

Highly correlated genes for ESCO1:

 

Showing top 20/987 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ESCO1CDC370.845777303
ESCO1DFFA0.810697303
ESCO1HNRNPF0.80873303
ESCO1CEP2900.801163303
ESCO1MAP3K70.790066303
ESCO1RAVER10.780871303
ESCO1ACBD50.778238303
ESCO1MCMBP0.77774403
ESCO1DMAP10.765122303
ESCO1CEP3500.761877303
ESCO1ANKRD100.753144303
ESCO1C1orf500.752063303
ESCO1COMMD70.748754303
ESCO1COQ40.747655303
ESCO1FAM102B0.747654303
ESCO1OTUD7B0.743864303
ESCO1FAM168A0.74173303
ESCO1RBM150.74104403
ESCO1ANGEL20.740709303
ESCO1SYNGR30.738835303

For details and further investigation, click here