ITGB3

 

Full name: integrin subunit beta 3 Alias Symbol: CD61|GPIIIa
Type: protein-coding gene Cytoband: 17q21.32
Entrez ID: 3690 HGNC ID: HGNC:6156 Ensembl Gene: ENSG00000259207 OMIM ID: 173470
Drug and gene relationship at DGIdb

 

ITGB3 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04510Focal adhesion
hsa04611Platelet activation
hsa04810Regulation of actin cytoskeleton
hsa04919Thyroid hormone signaling pathway
hsa05205Proteoglycans in cancer

 

Expression of ITGB3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ITGB3 3690 204626_s_at 0.0173 0.9578
GSE20347 ITGB3 3690 204626_s_at 0.0341 0.7156
GSE23400 ITGB3 3690 204626_s_at -0.0607 0.1433
GSE26886 ITGB3 3690 204626_s_at -0.1370 0.1153
GSE29001 ITGB3 3690 204626_s_at -0.2489 0.1100
GSE38129 ITGB3 3690 204626_s_at -0.0572 0.5615
GSE45670 ITGB3 3690 204626_s_at 0.0637 0.4469
GSE53622 ITGB3 3690 106936 -0.4225 0.0081
GSE53624 ITGB3 3690 106936 0.2946 0.0420
GSE63941 ITGB3 3690 204626_s_at -0.1942 0.3170
GSE77861 ITGB3 3690 204628_s_at -0.0664 0.6168
GSE97050 ITGB3 3690 A_24_P318656 -0.0455 0.8828
SRP007169 ITGB3 3690 RNAseq 2.5375 0.0001
SRP008496 ITGB3 3690 RNAseq 2.8438 0.0000
SRP133303 ITGB3 3690 RNAseq 0.5421 0.1724
SRP159526 ITGB3 3690 RNAseq 0.3100 0.3694
SRP193095 ITGB3 3690 RNAseq 1.4442 0.0000
SRP219564 ITGB3 3690 RNAseq 0.3535 0.6684
TCGA ITGB3 3690 RNAseq -0.7049 0.0002

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by ITGB3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ITGB3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ITGB3 3690 5 2 23
GSE20123 ITGB3 3690 5 2 23
GSE43470 ITGB3 3690 1 2 40
GSE46452 ITGB3 3690 32 0 27
GSE47630 ITGB3 3690 9 0 31
GSE54993 ITGB3 3690 2 4 64
GSE54994 ITGB3 3690 10 5 38
GSE60625 ITGB3 3690 4 0 7
GSE74703 ITGB3 3690 1 1 34
GSE74704 ITGB3 3690 4 1 15
TCGA ITGB3 3690 27 6 63

Total number of gains: 100; Total number of losses: 23; Total Number of normals: 365.  

 

Somatic mutations of ITGB3:

 

Generating mutation plots.

 

Highly correlated genes for ITGB3:

 

Showing top 20/717 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ITGB3MTAP0.791512505
ITGB3TAGAP0.787325303
ITGB3HIPK30.779036303
ITGB3CETN10.76267303
ITGB3ADAM220.76147404
ITGB3NELL10.753438303
ITGB3FRAS10.750927404
ITGB3GLI20.749178303
ITGB3HHLA10.744325504
ITGB3WDTC10.744244303
ITGB3CCDC70.733875404
ITGB3TCEAL60.727889303
ITGB3ADAM110.727756605
ITGB3SLC28A20.726518404
ITGB3FZR10.725884404
ITGB3RGSL10.72207303
ITGB3CRMP10.72188303
ITGB3KAT70.721018303
ITGB3SLC11A10.720201404
ITGB3OSBPL70.719968404

For details and further investigation, click here