| Full name: golgi brefeldin A resistant guanine nucleotide exchange factor 1 | Alias Symbol: KIAA0248|ARF1GEF | ||
| Type: protein-coding gene | Cytoband: 10q24.32 | ||
| Entrez ID: 8729 | HGNC ID: HGNC:4181 | Ensembl Gene: ENSG00000107862 | OMIM ID: 603698 |
| Drug and gene relationship at DGIdb | |||
Expression of GBF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GBF1 | 8729 | 201439_at | 0.1306 | 0.7334 | |
| GSE20347 | GBF1 | 8729 | 201439_at | -0.2153 | 0.1055 | |
| GSE23400 | GBF1 | 8729 | 201439_at | -0.1162 | 0.0281 | |
| GSE26886 | GBF1 | 8729 | 201439_at | 0.1681 | 0.2991 | |
| GSE29001 | GBF1 | 8729 | 201439_at | -0.2305 | 0.1195 | |
| GSE38129 | GBF1 | 8729 | 201439_at | -0.2660 | 0.0026 | |
| GSE45670 | GBF1 | 8729 | 201439_at | 0.1027 | 0.2167 | |
| GSE53622 | GBF1 | 8729 | 125898 | -0.5570 | 0.0000 | |
| GSE53624 | GBF1 | 8729 | 125898 | -0.2967 | 0.0000 | |
| GSE63941 | GBF1 | 8729 | 201439_at | 0.1584 | 0.5356 | |
| GSE77861 | GBF1 | 8729 | 201439_at | -0.0469 | 0.7957 | |
| GSE97050 | GBF1 | 8729 | A_23_P161237 | 0.0031 | 0.9917 | |
| SRP007169 | GBF1 | 8729 | RNAseq | -0.4331 | 0.2626 | |
| SRP008496 | GBF1 | 8729 | RNAseq | -0.3507 | 0.0839 | |
| SRP064894 | GBF1 | 8729 | RNAseq | -0.1111 | 0.4824 | |
| SRP133303 | GBF1 | 8729 | RNAseq | 0.0138 | 0.9101 | |
| SRP159526 | GBF1 | 8729 | RNAseq | -0.2369 | 0.3709 | |
| SRP193095 | GBF1 | 8729 | RNAseq | 0.1283 | 0.1757 | |
| SRP219564 | GBF1 | 8729 | RNAseq | 0.1978 | 0.3569 | |
| TCGA | GBF1 | 8729 | RNAseq | -0.0768 | 0.0670 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GBF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GBF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GBF1 | 8729 | 2 | 9 | 19 | |
| GSE20123 | GBF1 | 8729 | 2 | 8 | 20 | |
| GSE43470 | GBF1 | 8729 | 0 | 8 | 35 | |
| GSE46452 | GBF1 | 8729 | 0 | 11 | 48 | |
| GSE47630 | GBF1 | 8729 | 2 | 14 | 24 | |
| GSE54993 | GBF1 | 8729 | 8 | 0 | 62 | |
| GSE54994 | GBF1 | 8729 | 1 | 12 | 40 | |
| GSE60625 | GBF1 | 8729 | 0 | 0 | 11 | |
| GSE74703 | GBF1 | 8729 | 0 | 5 | 31 | |
| GSE74704 | GBF1 | 8729 | 1 | 4 | 15 | |
| TCGA | GBF1 | 8729 | 5 | 29 | 62 |
Total number of gains: 21; Total number of losses: 100; Total Number of normals: 367.
Somatic mutations of GBF1:
Generating mutation plots.
Highly correlated genes for GBF1:
Showing top 20/309 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GBF1 | MRPS18C | 0.813671 | 3 | 0 | 3 |
| GBF1 | ATXN3L | 0.757908 | 3 | 0 | 3 |
| GBF1 | USP25 | 0.744425 | 3 | 0 | 3 |
| GBF1 | CPEB4 | 0.744291 | 3 | 0 | 3 |
| GBF1 | C3orf38 | 0.736976 | 3 | 0 | 3 |
| GBF1 | DISC1 | 0.735608 | 3 | 0 | 3 |
| GBF1 | SLC6A9 | 0.733431 | 3 | 0 | 3 |
| GBF1 | CNOT10 | 0.731541 | 3 | 0 | 3 |
| GBF1 | GNG3 | 0.72916 | 3 | 0 | 3 |
| GBF1 | TMEM120A | 0.726018 | 3 | 0 | 3 |
| GBF1 | ILVBL | 0.721763 | 3 | 0 | 3 |
| GBF1 | MARS2 | 0.718127 | 3 | 0 | 3 |
| GBF1 | SUFU | 0.708163 | 3 | 0 | 3 |
| GBF1 | PRDM4 | 0.707183 | 3 | 0 | 3 |
| GBF1 | ITGB3 | 0.704907 | 3 | 0 | 3 |
| GBF1 | ZNF362 | 0.697214 | 3 | 0 | 3 |
| GBF1 | CCDC7 | 0.695963 | 4 | 0 | 4 |
| GBF1 | FN3K | 0.692269 | 3 | 0 | 3 |
| GBF1 | GPR108 | 0.692151 | 3 | 0 | 3 |
| GBF1 | FLYWCH2 | 0.690089 | 3 | 0 | 3 |
For details and further investigation, click here
