| Full name: kelch domain containing 3 | Alias Symbol: PEAS|hPeas|dJ20C7.3 | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 116138 | HGNC ID: HGNC:20704 | Ensembl Gene: ENSG00000124702 | OMIM ID: 611248 |
| Drug and gene relationship at DGIdb | |||
Expression of KLHDC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLHDC3 | 116138 | 214383_x_at | 0.8904 | 0.0598 | |
| GSE20347 | KLHDC3 | 116138 | 208784_s_at | 0.1271 | 0.3355 | |
| GSE23400 | KLHDC3 | 116138 | 214383_x_at | 0.1076 | 0.0585 | |
| GSE26886 | KLHDC3 | 116138 | 208784_s_at | -0.3674 | 0.1869 | |
| GSE29001 | KLHDC3 | 116138 | 208784_s_at | 0.1723 | 0.5335 | |
| GSE38129 | KLHDC3 | 116138 | 214383_x_at | 0.1458 | 0.2497 | |
| GSE45670 | KLHDC3 | 116138 | 208784_s_at | 0.0446 | 0.6558 | |
| GSE53622 | KLHDC3 | 116138 | 8583 | 0.0960 | 0.1470 | |
| GSE53624 | KLHDC3 | 116138 | 8583 | 0.4375 | 0.0000 | |
| GSE63941 | KLHDC3 | 116138 | 214383_x_at | 1.9360 | 0.0003 | |
| GSE77861 | KLHDC3 | 116138 | 208784_s_at | -0.0904 | 0.5111 | |
| GSE97050 | KLHDC3 | 116138 | A_24_P343255 | -0.2722 | 0.2333 | |
| SRP007169 | KLHDC3 | 116138 | RNAseq | -1.0069 | 0.0052 | |
| SRP008496 | KLHDC3 | 116138 | RNAseq | -0.9606 | 0.0000 | |
| SRP064894 | KLHDC3 | 116138 | RNAseq | 0.5741 | 0.0524 | |
| SRP133303 | KLHDC3 | 116138 | RNAseq | 0.1075 | 0.4991 | |
| SRP159526 | KLHDC3 | 116138 | RNAseq | 0.2634 | 0.1308 | |
| SRP193095 | KLHDC3 | 116138 | RNAseq | 0.0123 | 0.9138 | |
| SRP219564 | KLHDC3 | 116138 | RNAseq | 0.3307 | 0.4144 | |
| TCGA | KLHDC3 | 116138 | RNAseq | -0.0189 | 0.7142 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by KLHDC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLHDC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLHDC3 | 116138 | 7 | 0 | 23 | |
| GSE20123 | KLHDC3 | 116138 | 7 | 0 | 23 | |
| GSE43470 | KLHDC3 | 116138 | 6 | 0 | 37 | |
| GSE46452 | KLHDC3 | 116138 | 2 | 9 | 48 | |
| GSE47630 | KLHDC3 | 116138 | 8 | 4 | 28 | |
| GSE54993 | KLHDC3 | 116138 | 3 | 2 | 65 | |
| GSE54994 | KLHDC3 | 116138 | 11 | 4 | 38 | |
| GSE60625 | KLHDC3 | 116138 | 0 | 1 | 10 | |
| GSE74703 | KLHDC3 | 116138 | 6 | 0 | 30 | |
| GSE74704 | KLHDC3 | 116138 | 3 | 0 | 17 | |
| TCGA | KLHDC3 | 116138 | 21 | 13 | 62 |
Total number of gains: 74; Total number of losses: 33; Total Number of normals: 381.
Somatic mutations of KLHDC3:
Generating mutation plots.
Highly correlated genes for KLHDC3:
Showing top 20/497 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLHDC3 | PPP5C | 0.8913 | 3 | 0 | 3 |
| KLHDC3 | MPV17L | 0.851517 | 3 | 0 | 3 |
| KLHDC3 | TMEM222 | 0.818155 | 3 | 0 | 3 |
| KLHDC3 | FLYWCH2 | 0.815601 | 3 | 0 | 3 |
| KLHDC3 | TNK1 | 0.812478 | 3 | 0 | 3 |
| KLHDC3 | DEDD | 0.786014 | 3 | 0 | 3 |
| KLHDC3 | PTPN6 | 0.768274 | 3 | 0 | 3 |
| KLHDC3 | CCDC124 | 0.766528 | 3 | 0 | 3 |
| KLHDC3 | MGMT | 0.765079 | 3 | 0 | 3 |
| KLHDC3 | SND1 | 0.762475 | 3 | 0 | 3 |
| KLHDC3 | WDR5 | 0.761966 | 3 | 0 | 3 |
| KLHDC3 | SF3A1 | 0.758623 | 3 | 0 | 3 |
| KLHDC3 | KDM4A | 0.757364 | 4 | 0 | 4 |
| KLHDC3 | CDC37 | 0.756184 | 3 | 0 | 3 |
| KLHDC3 | POLDIP2 | 0.749438 | 3 | 0 | 3 |
| KLHDC3 | MAST1 | 0.746387 | 3 | 0 | 3 |
| KLHDC3 | JAG2 | 0.743285 | 3 | 0 | 3 |
| KLHDC3 | B4GALT2 | 0.74142 | 3 | 0 | 3 |
| KLHDC3 | UPF1 | 0.739204 | 4 | 0 | 3 |
| KLHDC3 | INO80E | 0.738455 | 3 | 0 | 3 |
For details and further investigation, click here
