| Full name: capicua transcriptional repressor | Alias Symbol: KIAA0306 | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 23152 | HGNC ID: HGNC:14214 | Ensembl Gene: ENSG00000079432 | OMIM ID: 612082 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CIC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CIC | 23152 | 212784_at | 0.3772 | 0.2165 | |
| GSE20347 | CIC | 23152 | 212784_at | 0.2377 | 0.0052 | |
| GSE23400 | CIC | 23152 | 212784_at | 0.2170 | 0.0000 | |
| GSE26886 | CIC | 23152 | 212784_at | 0.7178 | 0.0000 | |
| GSE29001 | CIC | 23152 | 212784_at | 0.2940 | 0.2602 | |
| GSE38129 | CIC | 23152 | 212784_at | 0.0697 | 0.3752 | |
| GSE45670 | CIC | 23152 | 212784_at | 0.0807 | 0.3809 | |
| GSE53622 | CIC | 23152 | 30593 | 0.0316 | 0.4927 | |
| GSE53624 | CIC | 23152 | 30593 | 0.0847 | 0.0276 | |
| GSE63941 | CIC | 23152 | 212784_at | 0.0077 | 0.9798 | |
| GSE77861 | CIC | 23152 | 212784_at | 0.1611 | 0.3509 | |
| GSE97050 | CIC | 23152 | A_23_P55731 | 0.2290 | 0.2569 | |
| SRP007169 | CIC | 23152 | RNAseq | 1.2312 | 0.0052 | |
| SRP008496 | CIC | 23152 | RNAseq | 0.4510 | 0.2367 | |
| SRP064894 | CIC | 23152 | RNAseq | 0.3068 | 0.1276 | |
| SRP133303 | CIC | 23152 | RNAseq | 0.1041 | 0.5231 | |
| SRP159526 | CIC | 23152 | RNAseq | 0.7370 | 0.0582 | |
| SRP193095 | CIC | 23152 | RNAseq | 0.6192 | 0.0002 | |
| SRP219564 | CIC | 23152 | RNAseq | 0.0195 | 0.9342 | |
| TCGA | CIC | 23152 | RNAseq | -0.0418 | 0.3325 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CIC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CIC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CIC | 23152 | 4 | 4 | 22 | |
| GSE20123 | CIC | 23152 | 4 | 3 | 23 | |
| GSE43470 | CIC | 23152 | 4 | 11 | 28 | |
| GSE46452 | CIC | 23152 | 47 | 1 | 11 | |
| GSE47630 | CIC | 23152 | 8 | 6 | 26 | |
| GSE54993 | CIC | 23152 | 17 | 4 | 49 | |
| GSE54994 | CIC | 23152 | 7 | 12 | 34 | |
| GSE60625 | CIC | 23152 | 9 | 0 | 2 | |
| GSE74703 | CIC | 23152 | 4 | 7 | 25 | |
| GSE74704 | CIC | 23152 | 4 | 1 | 15 | |
| TCGA | CIC | 23152 | 13 | 16 | 67 |
Total number of gains: 121; Total number of losses: 65; Total Number of normals: 302.
Somatic mutations of CIC:
Generating mutation plots.
Highly correlated genes for CIC:
Showing top 20/1065 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CIC | PHRF1 | 0.81118 | 3 | 0 | 3 |
| CIC | BRI3 | 0.787911 | 3 | 0 | 3 |
| CIC | MBD4 | 0.779723 | 3 | 0 | 3 |
| CIC | ZNF518B | 0.778418 | 3 | 0 | 3 |
| CIC | OAF | 0.768236 | 3 | 0 | 3 |
| CIC | KRTCAP2 | 0.765596 | 4 | 0 | 4 |
| CIC | ZNF316 | 0.76021 | 3 | 0 | 3 |
| CIC | RELA | 0.759192 | 3 | 0 | 3 |
| CIC | B3GALT6 | 0.757754 | 3 | 0 | 3 |
| CIC | TBC1D25 | 0.756702 | 3 | 0 | 3 |
| CIC | DHX36 | 0.755825 | 3 | 0 | 3 |
| CIC | CUEDC1 | 0.755665 | 3 | 0 | 3 |
| CIC | RICTOR | 0.754568 | 3 | 0 | 3 |
| CIC | SDR39U1 | 0.749527 | 3 | 0 | 3 |
| CIC | SENP5 | 0.746251 | 4 | 0 | 4 |
| CIC | MIA3 | 0.745843 | 3 | 0 | 3 |
| CIC | TP53I13 | 0.744228 | 4 | 0 | 4 |
| CIC | RIOK1 | 0.743695 | 3 | 0 | 3 |
| CIC | SLC25A28 | 0.740651 | 3 | 0 | 3 |
| CIC | TMEM150A | 0.735606 | 3 | 0 | 3 |
For details and further investigation, click here
