Full name: RELA proto-oncogene, NF-kB subunit	Alias Symbol: p65
Type: protein-coding gene	Cytoband: 11q13.1
Entrez ID: 5970	HGNC ID: HGNC:9955	Ensembl Gene: ENSG00000173039	OMIM ID: 164014
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 24/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

---

 

RELA involved pathways:

KEGG pathway	Description	View
hsa04010	MAPK signaling pathway	View
hsa04014	Ras signaling pathway	View
hsa04024	cAMP signaling pathway	View
hsa04062	Chemokine signaling pathway	View
hsa04064	NF-kappa B signaling pathway	View
hsa04066	HIF-1 signaling pathway	View
hsa04071	Sphingolipid signaling pathway	View
hsa04151	PI3K-Akt signaling pathway	View
hsa04210	Apoptosis	View
hsa04211	Longevity regulating pathway - mammal	View
hsa04380	Osteoclast differentiation	View
hsa04620	Toll-like receptor signaling pathway	View
hsa04621	NOD-like receptor signaling pathway	View
hsa04622	RIG-I-like receptor signaling pathway	View
hsa04623	Cytosolic DNA-sensing pathway	View
hsa04660	T cell receptor signaling pathway	View
hsa04662	B cell receptor signaling pathway	View
hsa04668	TNF signaling pathway	View
hsa04722	Neurotrophin signaling pathway	View
hsa04917	Prolactin signaling pathway	View
hsa04920	Adipocytokine signaling pathway	View
hsa04931	Insulin resistance	View
hsa04932	Non-alcoholic fatty liver disease (NAFLD)	View
hsa04933	AGE-RAGE signaling pathway in diabetic complications	View
hsa05030	Cocaine addiction	View
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	View
hsa05131	Shigellosis	View
hsa05132	Salmonella infection	View
hsa05133	Pertussis	View
hsa05134	Legionellosis	View
hsa05140	Leishmaniasis	View
hsa05142	Chagas disease (American trypanosomiasis)	View
hsa05145	Toxoplasmosis	View
hsa05152	Tuberculosis	View
hsa05160	Hepatitis C	View
hsa05161	Hepatitis B	View
hsa05162	Measles	View
hsa05164	Influenza A	View
hsa05166	HTLV-I infection	View
hsa05168	Herpes simplex infection	View
hsa05169	Epstein-Barr virus infection	View
hsa05200	Pathways in cancer	View
hsa05212	Pancreatic cancer	View
hsa05215	Prostate cancer	View
hsa05220	Chronic myeloid leukemia	View
hsa05221	Acute myeloid leukemia	View
hsa05222	Small cell lung cancer	View
hsa05321	Inflammatory bowel disease (IBD)	View

---

 

Expression of RELA:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	RELA	5970	201783_s_at	-0.0540	0.8865	Show
GSE20347	RELA	5970	201783_s_at	0.0165	0.9231	Show
GSE23400	RELA	5970	201783_s_at	-0.0564	0.2515	Show
GSE26886	RELA	5970	201783_s_at	0.1896	0.3599	Show
GSE29001	RELA	5970	201783_s_at	-0.3778	0.0234	Show
GSE38129	RELA	5970	201783_s_at	-0.1036	0.3411	Show
GSE45670	RELA	5970	201783_s_at	-0.1640	0.2066	Show
GSE53622	RELA	5970	52082	-0.1009	0.2008	Show
GSE53624	RELA	5970	67171	0.1011	0.1001	Show
GSE63941	RELA	5970	201783_s_at	0.2312	0.5098	Show
GSE77861	RELA	5970	201783_s_at	0.3183	0.0618	Show
GSE97050	RELA	5970	A_33_P3209433	0.1104	0.6173	Show
SRP007169	RELA	5970	RNAseq	0.1110	0.8215	Show
SRP008496	RELA	5970	RNAseq	-0.0338	0.9066	Show
SRP064894	RELA	5970	RNAseq	-0.2769	0.0758	Show
SRP133303	RELA	5970	RNAseq	0.0942	0.6655	Show
SRP159526	RELA	5970	RNAseq	-0.3604	0.0355	Show
SRP193095	RELA	5970	RNAseq	0.1105	0.3048	Show
SRP219564	RELA	5970	RNAseq	-0.3622	0.1890	Show
TCGA	RELA	5970	RNAseq	0.0286	0.5055	Show

Upregulated datasets: 0; Downregulated datasets: 0.  Download Data

---

 

Survival by RELA expression:

 

---

Copy number change of RELA:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	RELA	5970	8	5	17	Show
GSE20123	RELA	5970	8	5	17	Show
GSE43470	RELA	5970	4	1	38	Show
GSE46452	RELA	5970	11	3	45	Show
GSE47630	RELA	5970	7	5	28	Show
GSE54993	RELA	5970	3	0	67	Show
GSE54994	RELA	5970	7	5	41	Show
GSE60625	RELA	5970	0	3	8	Show
GSE74703	RELA	5970	3	0	33	Show
GSE74704	RELA	5970	6	3	11	Show
TCGA	RELA	5970	23	7	66	Show

Total number of gains: 80; Total number of losses: 37; Total Number of normals: 371.  Download Data

---

 

Somatic mutations of RELA:

 

---

 

Highly correlated genes for RELA:

 

Showing top 20/143 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
RELA	CIC	0.759192	3	0	3
RELA	S100A6	0.744684	4	0	4
RELA	CTNNBL1	0.73717	3	0	3
RELA	ZDHHC9	0.729849	3	0	3
RELA	LPCAT2	0.714095	3	0	3
RELA	PORCN	0.710382	3	0	3
RELA	RNF25	0.708926	3	0	3
RELA	FLNB	0.703268	3	0	3
RELA	SIK1	0.697642	3	0	3
RELA	PLTP	0.693018	3	0	3
RELA	TNFRSF12A	0.691234	3	0	3
RELA	RGS14	0.690212	3	0	3
RELA	C19orf54	0.685547	4	0	3
RELA	PMF1	0.683204	3	0	3
RELA	BMP2	0.681703	3	0	3
RELA	PXN	0.678754	4	0	3
RELA	SPIRE1	0.678269	3	0	3
RELA	MRPL55	0.675858	3	0	3
RELA	FTSJ1	0.670031	3	0	3
RELA	AQR	0.665504	3	0	3

For details and further investigation, click here