| Full name: methyl-CpG binding domain 4, DNA glycosylase | Alias Symbol: MED1 | ||
| Type: protein-coding gene | Cytoband: 3q21.3 | ||
| Entrez ID: 8930 | HGNC ID: HGNC:6919 | Ensembl Gene: ENSG00000129071 | OMIM ID: 603574 |
| Drug and gene relationship at DGIdb | |||
Expression of MBD4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MBD4 | 8930 | 209579_s_at | 0.6204 | 0.1386 | |
| GSE20347 | MBD4 | 8930 | 209579_s_at | 0.7905 | 0.0000 | |
| GSE23400 | MBD4 | 8930 | 209579_s_at | 0.7555 | 0.0000 | |
| GSE26886 | MBD4 | 8930 | 209579_s_at | -0.0252 | 0.9381 | |
| GSE29001 | MBD4 | 8930 | 209579_s_at | 1.0934 | 0.0001 | |
| GSE38129 | MBD4 | 8930 | 209579_s_at | 0.6884 | 0.0001 | |
| GSE45670 | MBD4 | 8930 | 209579_s_at | 0.5546 | 0.0009 | |
| GSE53622 | MBD4 | 8930 | 82200 | 0.6818 | 0.0000 | |
| GSE53624 | MBD4 | 8930 | 82200 | 0.8157 | 0.0000 | |
| GSE63941 | MBD4 | 8930 | 209579_s_at | 0.2116 | 0.5854 | |
| GSE77861 | MBD4 | 8930 | 209579_s_at | 1.0020 | 0.0025 | |
| GSE97050 | MBD4 | 8930 | A_23_P92154 | 0.4317 | 0.3103 | |
| SRP007169 | MBD4 | 8930 | RNAseq | 1.1772 | 0.0071 | |
| SRP008496 | MBD4 | 8930 | RNAseq | 1.3209 | 0.0000 | |
| SRP064894 | MBD4 | 8930 | RNAseq | 0.7513 | 0.0000 | |
| SRP133303 | MBD4 | 8930 | RNAseq | 0.6188 | 0.0001 | |
| SRP159526 | MBD4 | 8930 | RNAseq | 0.2324 | 0.4534 | |
| SRP193095 | MBD4 | 8930 | RNAseq | 0.4250 | 0.0005 | |
| SRP219564 | MBD4 | 8930 | RNAseq | 0.3465 | 0.1350 | |
| TCGA | MBD4 | 8930 | RNAseq | 0.1720 | 0.0018 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by MBD4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MBD4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MBD4 | 8930 | 17 | 0 | 13 | |
| GSE20123 | MBD4 | 8930 | 17 | 0 | 13 | |
| GSE43470 | MBD4 | 8930 | 19 | 0 | 24 | |
| GSE46452 | MBD4 | 8930 | 14 | 5 | 40 | |
| GSE47630 | MBD4 | 8930 | 18 | 3 | 19 | |
| GSE54993 | MBD4 | 8930 | 2 | 8 | 60 | |
| GSE54994 | MBD4 | 8930 | 32 | 3 | 18 | |
| GSE60625 | MBD4 | 8930 | 0 | 6 | 5 | |
| GSE74703 | MBD4 | 8930 | 17 | 0 | 19 | |
| GSE74704 | MBD4 | 8930 | 13 | 0 | 7 | |
| TCGA | MBD4 | 8930 | 58 | 5 | 33 |
Total number of gains: 207; Total number of losses: 30; Total Number of normals: 251.
Somatic mutations of MBD4:
Generating mutation plots.
Highly correlated genes for MBD4:
Showing top 20/1242 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MBD4 | ZNF557 | 0.871929 | 3 | 0 | 3 |
| MBD4 | ALKBH6 | 0.809175 | 4 | 0 | 4 |
| MBD4 | SLC39A3 | 0.783535 | 3 | 0 | 3 |
| MBD4 | CIC | 0.779723 | 3 | 0 | 3 |
| MBD4 | PXMP4 | 0.77408 | 3 | 0 | 3 |
| MBD4 | GTPBP8 | 0.761735 | 8 | 0 | 8 |
| MBD4 | CPNE1 | 0.76157 | 3 | 0 | 3 |
| MBD4 | PARP14 | 0.760036 | 6 | 0 | 6 |
| MBD4 | ATR | 0.755419 | 11 | 0 | 10 |
| MBD4 | LRRC58 | 0.754353 | 5 | 0 | 4 |
| MBD4 | U2SURP | 0.751282 | 9 | 0 | 8 |
| MBD4 | MMS22L | 0.742204 | 3 | 0 | 3 |
| MBD4 | UBXN7 | 0.741291 | 10 | 0 | 10 |
| MBD4 | CCDC14 | 0.738196 | 6 | 0 | 6 |
| MBD4 | C12orf73 | 0.735055 | 3 | 0 | 3 |
| MBD4 | TOPBP1 | 0.733766 | 12 | 0 | 11 |
| MBD4 | ADAR | 0.733766 | 10 | 0 | 10 |
| MBD4 | IPO9 | 0.733419 | 7 | 0 | 7 |
| MBD4 | FLVCR1 | 0.730248 | 6 | 0 | 6 |
| MBD4 | WDR81 | 0.727913 | 4 | 0 | 3 |
For details and further investigation, click here
