| Full name: brain protein I3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q21.3 | ||
| Entrez ID: 25798 | HGNC ID: HGNC:1109 | Ensembl Gene: ENSG00000164713 | OMIM ID: 615628 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of BRI3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BRI3 | 25798 | 223376_s_at | 0.3507 | 0.2503 | |
| GSE26886 | BRI3 | 25798 | 223376_s_at | 1.2927 | 0.0000 | |
| GSE45670 | BRI3 | 25798 | 223376_s_at | -0.0109 | 0.9614 | |
| GSE53622 | BRI3 | 25798 | 112424 | 0.2741 | 0.0001 | |
| GSE53624 | BRI3 | 25798 | 112424 | 0.3503 | 0.0000 | |
| GSE63941 | BRI3 | 25798 | 223376_s_at | -1.2455 | 0.0318 | |
| GSE77861 | BRI3 | 25798 | 223376_s_at | 0.6341 | 0.0703 | |
| GSE97050 | BRI3 | 25798 | A_23_P122915 | 0.0626 | 0.7663 | |
| SRP007169 | BRI3 | 25798 | RNAseq | -0.3118 | 0.4108 | |
| SRP008496 | BRI3 | 25798 | RNAseq | -0.1210 | 0.6244 | |
| SRP064894 | BRI3 | 25798 | RNAseq | 0.4340 | 0.1809 | |
| SRP133303 | BRI3 | 25798 | RNAseq | 0.4879 | 0.0367 | |
| SRP159526 | BRI3 | 25798 | RNAseq | 0.3516 | 0.2817 | |
| SRP193095 | BRI3 | 25798 | RNAseq | -0.0876 | 0.6328 | |
| SRP219564 | BRI3 | 25798 | RNAseq | 0.5871 | 0.0789 | |
| TCGA | BRI3 | 25798 | RNAseq | -0.1114 | 0.0379 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by BRI3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BRI3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BRI3 | 25798 | 13 | 0 | 17 | |
| GSE20123 | BRI3 | 25798 | 12 | 0 | 18 | |
| GSE43470 | BRI3 | 25798 | 6 | 2 | 35 | |
| GSE46452 | BRI3 | 25798 | 12 | 0 | 47 | |
| GSE47630 | BRI3 | 25798 | 8 | 3 | 29 | |
| GSE54993 | BRI3 | 25798 | 1 | 9 | 60 | |
| GSE54994 | BRI3 | 25798 | 15 | 3 | 35 | |
| GSE60625 | BRI3 | 25798 | 0 | 0 | 11 | |
| GSE74703 | BRI3 | 25798 | 6 | 1 | 29 | |
| GSE74704 | BRI3 | 25798 | 9 | 0 | 11 | |
| TCGA | BRI3 | 25798 | 54 | 4 | 38 |
Total number of gains: 136; Total number of losses: 22; Total Number of normals: 330.
Somatic mutations of BRI3:
Generating mutation plots.
Highly correlated genes for BRI3:
Showing top 20/1058 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BRI3 | KRTCAP2 | 0.837339 | 3 | 0 | 3 |
| BRI3 | IDS | 0.835263 | 3 | 0 | 3 |
| BRI3 | TUBA1B | 0.80949 | 3 | 0 | 3 |
| BRI3 | NCOR2 | 0.789028 | 4 | 0 | 4 |
| BRI3 | FHL3 | 0.788235 | 3 | 0 | 3 |
| BRI3 | CIC | 0.787911 | 3 | 0 | 3 |
| BRI3 | SPIRE1 | 0.777646 | 3 | 0 | 3 |
| BRI3 | RAD23A | 0.776046 | 4 | 0 | 4 |
| BRI3 | IFITM1 | 0.773591 | 3 | 0 | 3 |
| BRI3 | ZNF496 | 0.768156 | 4 | 0 | 4 |
| BRI3 | ALKBH6 | 0.756934 | 3 | 0 | 3 |
| BRI3 | SSBP4 | 0.756029 | 4 | 0 | 3 |
| BRI3 | CDON | 0.755054 | 3 | 0 | 3 |
| BRI3 | DYNC2H1 | 0.752035 | 3 | 0 | 3 |
| BRI3 | TSPYL2 | 0.74909 | 3 | 0 | 3 |
| BRI3 | TTI2 | 0.748961 | 3 | 0 | 3 |
| BRI3 | TRIM47 | 0.74846 | 4 | 0 | 4 |
| BRI3 | MCAM | 0.748075 | 3 | 0 | 3 |
| BRI3 | NGF | 0.744511 | 3 | 0 | 3 |
| BRI3 | PET117 | 0.742093 | 3 | 0 | 3 |
For details and further investigation, click here
